David Fenyo

David Fenyo, PhD

Institute for Systems Genetics

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
biostatistics, cancer, computational biology, genomics, imaging, pharmacology, proteomics, systems biology
Summary

Our goal is detailed understanding of the dynamics of cellular processes, and we apply mathematical, statistical and computational methods to solve practical problems in experimental design optimization, quantitative data analysis, and in the modeling of biological systems for generating new hypotheses. The focus of our research is proteomic data analysis: we are developing computational methods and databases for protein identification, characterization and quantitation using mass spectrometry-based proteomics.

Phone

917-754-6066

Academic office

435 E 30th St

9th Floor, Room 907

New York, NY 10016

Lab Website
Fenyo Lab
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Positions

Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Director, Biomedical Informatics Masters Training Program

Director, Systems and Computational Biomedicine PhD Training Program

Graduate Education

PhD from Uppsala University

Postdoctoral Training

Rockefeller University, Chait Lab

Mechanistic basis for impaired B cell depletion after anti-CD20 treatment of African American with neuro-inflammatory disorders

See All Studies (1)

Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1

Stephan, Gabriele; Haddock, Sara; Wang, Shuai; Erdjument-Bromage, Hediye; Liu, Wenke; Ravn-Boess, Niklas; Frenster, Joshua D; Bready, Devin; Cai, Julia; Ronnen, Rebecca; Sabio-Ortiz, Jonathan; Fenyo, David; Neubert, Thomas A; Placantonakis, Dimitris G

Cell reports. 2024 May 28; 43(5):114229

Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares

Azzouz, Doua F; Chen, Ze; Izmirly, Peter M; Chen, Lea Ann; Li, Zhi; Zhang, Chongda; Mieles, David; Trujillo, Kate; Heguy, Adriana; Pironti, Alejandro; Putzel, Greg G; Schwudke, Dominik; Fenyo, David; Buyon, Jill P; Alekseyenko, Alexander V; Gisch, Nicolas; Silverman, Gregg J

Annals of the rheumatic diseases. 2023 Oct; 82(10):1315-1327

Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer

Chowdhury, Shrabanti; Kennedy, Jacob J; Ivey, Richard G; Murillo, Oscar D; Hosseini, Noshad; Song, Xiaoyu; Petralia, Francesca; Calinawan, Anna; Savage, Sara R; Berry, Anna B; Reva, Boris; Ozbek, Umut; Krek, Azra; Ma, Weiping; da Veiga Leprevost, Felipe; Ji, Jiayi; Yoo, Seungyeul; Lin, Chenwei; Voytovich, Uliana J; Huang, Yajue; Lee, Sun-Hee; Bergan, Lindsay; Lorentzen, Travis D; Mesri, Mehdi; Rodriguez, Henry; Hoofnagle, Andrew N; Herbert, Zachary T; Nesvizhskii, Alexey I; Zhang, Bing; Whiteaker, Jeffrey R; Fenyo, David; McKerrow, Wilson; Wang, Joshua; Schürer, Stephan C; Stathias, Vasileios; Chen, X Steven; Barcellos-Hoff, Mary Helen; Starr, Timothy K; Winterhoff, Boris J; Nelson, Andrew C; Mok, Samuel C; Kaufmann, Scott H; Drescher, Charles; Cieslik, Marcin; Wang, Pei; Birrer, Michael J; Paulovich, Amanda G

Cell. 2023 Aug 03; 186(16):3476-3498.e35

Transposon insertion profiling by sequencing (TIPseq) identifies novel LINE-1 insertions in human sperm

Berteli, Thalita S; Wang, Fang; McKerrow, Wilson; Navarro, Paula A; Fenyo, David; Boeke, Jef D; Kohlrausch, Fabiana B; Keefe, David L

Journal of assisted reproduction & genetics. 2023 Aug; 40(8):1835-1843

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma

Frenster, Joshua D; Erdjument-Bromage, Hediye; Stephan, Gabriele; Ravn-Boess, Niklas; Wang, Shuai; Liu, Wenke; Bready, Devin; Wilcox, Jordan; Kieslich, Björn; Jankovic, Manuel; Wilde, Caroline; Horn, Susanne; Sträter, Norbert; Liebscher, Ines; Schöneberg, Torsten; Fenyo, David; Neubert, Thomas A; Placantonakis, Dimitris G

Cell reports. 2023 Jun 23; 42(7):112679

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer

Deng, Jiehui; Peng, David H; Fenyo, David; Yuan, Hao; Lopez, Alfonso; Levin, Daniel S; Meynardie, Mary; Quinteros, Mari; Ranieri, Michela; Sahu, Soumyadip; Lau, Sally C M; Shum, Elaine; Velcheti, Vamsidhar; Punekar, Salman R; Rekhtman, Natasha; Dowling, Catríona M; Weerasekara, Vajira; Xue, Yun; Ji, Hongbin; Siu, Yik; Jones, Drew; Hata, Aaron N; Shimamura, Takeshi; Poirier, John T; Rudin, Charles M; Hattori, Takamitsu; Koide, Shohei; Papagiannakopoulos, Thales; Neel, Benjamin G; Bardeesy, Nabeel; Wong, Kwok-Kin

bioRxiv.org : the preprint server for biology. 2023 Apr 20;

Machine learning decision support model for radical cystectomy discharge planning

Zhao, Calvin C; Bjurlin, Marc A; Wysock, James S; Taneja, Samir S; Huang, William C; Fenyo, David; Matulewicz, Richard S

Urologic oncology. 2022 Oct; 40(10):453.e9-453.e18

Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

Cheng, Pan; Zhao, Xin; Katsnelson, Lizabeth; Camacho-Hernandez, Elaine M; Mermerian, Angela; Mays, Joseph C; Lippman, Scott M; Rosales-Alvarez, Reyna Edith; Moya, Raquel; Shwetar, Jasmine; Grun, Dominic; Fenyo, David; Davoli, Teresa

eLife. 2022 Sep 21; 11:

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