Professor, Department of Microbiology
Professor, Department of Urology
Nuclear receptors are ligand-regulated transcription factors that control diverse physiological and developmental processes. The focus of my laboratory is to understand the mechanism of signal transduction and transcriptional regulation by nuclear hormone receptors, including LXR alpha in cardiovascular disease, the glucocorticoid receptor (GR) in immune and neuronal function, and the androgen receptor (AR) in prostate cancer. We use state-of-the-art genetic (mouse knock-outs and knock-ins and CRISPR-Cas9 gene editing), biochemical (RNA-/ ChIP-seq and high-throughput siRNA and small molecules screens) as well as proteomic strategies to identify macromolecular complexes important in nuclear receptor activity to elucidate the mechanism of LXR, AR and GR function in vivo. Characterizing factors that control nuclear receptor activity can lead to potential new therapeutic strategies for prostate cancer, atherosclerosis as well as stress related anxiety, and depression.
Acting Vice Chair, Education, Department of Microbiology
PhD from Brandeis University
Fellowship, University of California, San Francisco, Mechanism of Glucocotricoid Receptor
Laryngoscope. 2023 Nov; 133(11):3116-3122
Scientific reports. 2023 Oct 25; 13(1):18227
Molecular cancer therapeutics. 2023 Oct 02; 22(10):1166-1181
Laryngoscope. 2023 Oct; 133(10):2704-2711
Annals of otology rhinology & laryngology. 2023 Jul 27; 34894231188571
Laryngoscope. 2023 May; 133(5):1169-1175
Scientific reports. 2022 Jul 14; 12(1):12031
Acta neuropathologica communications. 2022 06 22; 10(1):91