Helen E. Scharfman

My Research

Keywords

hippocampus and parahippocampal areas, their role in normal function and their contribution to neurological disorders and mental illness, neurotrophins (BDNF)and neuronal plasticity , neurogenesis in the dentate gyrus , mechanisms controlling neuronal excitability; seizures; epilepsy, neuronal modulation by reproductive steroids, brain and spinal cord injury; neuroprotection, imaging, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience

Contact

Phone

845-398-5427

Helen.Scharfman@nyulangone.org

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Research Focus Timeline

These focus areas and their associated publications are derived from medical subject headings from PubMed.

represents one publication

*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Positions & Education

Positions

Professor, Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine

Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine

Professor, Department of Psychiatry at NYU Grossman School of Medicine

Selected Publications

Increasing adult-born neurons protects mice from epilepsy. Opens in a new tab

Jain, Swati; LaFrancois, John J; Gerencer, Kasey; Botterill, Justin J; Kennedy, Meghan; Criscuolo, Chiara; Scharfman, Helen E

eLife. 2024 Oct 24; 12:

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease. Opens in a new tab

Chartampila, Elissavet; Elayouby, Karim S; Leary, Paige; LaFrancois, John J; Alcantara-Gonzalez, David; Jain, Swati; Gerencer, Kasey; Botterill, Justin J; Ginsberg, Stephen D; Scharfman, Helen E

eLife. 2024 Jun 21; 12:

Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model. Opens in a new tab

Criscuolo, Chiara; Chartampila, Elissavet; Ginsberg, Stephen D; Scharfman, Helen E

eNeuro. 2024 Mar; 11(3):

Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum. Opens in a new tab

Lisgaras, Christos Panagiotis; Scharfman, Helen E

Neurobiology of disease. 2023 Oct 15; 187:106294

Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. Opens in a new tab

Whitebirch, Alexander C; Santoro, Bina; Barnett, Anastasia; Lisgaras, Christos Panagiotis; Scharfman, Helen E; Siegelbaum, Steven A

Journal of neuroscience. 2023 Oct 11; 43(41):6930-6949

Assessments of dentate gyrus function: discoveries and debates. Opens in a new tab

Borzello, Mia; Ramirez, Steve; Treves, Alessandro; Lee, Inah; Scharfman, Helen; Stark, Craig; Knierim, James J; Rangel, Lara M

Nature reviews. Neuroscience. 2023 Aug; 24(8):502-517

Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Opens in a new tab

Rosenberg, Evan C; Chamberland, Simon; Bazelot, Michael; Nebet, Erica R; Wang, Xiaohan; McKenzie, Sam; Jain, Swati; Greenhill, Stuart; Wilson, Max; Marley, Nicole; Salah, Alejandro; Bailey, Shanice; Patra, Pabitra Hriday; Rose, Rebecca; Chenouard, Nicolas; Sun, Simón E D; Jones, Drew; Buzsáki, György; Devinsky, Orrin; Woodhall, Gavin; Scharfman, Helen E; Whalley, Benjamin J; Tsien, Richard W

Neuron. 2023 Apr 19; 111(8):1282-1300.e8

High Frequency Oscillations (250-500Hz) in Animal Models of Alzheimer's Disease and Two Animal Models of Epilepsy. Opens in a new tab