Hannah Klein

Hannah L. Klein, Ph.D.
Professor, Departments of Biochemistry and Molecular Pharmacology, Medicine and Pathology
Lab:  ACLS Building, 3rd Floor, 450 East 29th Street, New York, NY  10016
Office:  Smilow 201, 550 First Avenue, New York, NY 10016
Office: 212-263-5778, 212-263-9484
Lab: 212-263-5952
Email:  hannah.klein@nyumc.org

Lab Website

KEY INTERESTS:
DNA damage and repair, recombination, genome stability

BIOGRAPHICAL DETAILS:

Graduate Education: PhD in Genetics at University of Washington (1976)
Postdoctoral Training:  Princeton University, University of Chicago (1976-1981)
Academic Appointments:  1981: Assistant Professor of Biochemistry
1987: Associate Professor of Biochemistry
1997: Professor of Biochemistry
Major Responsibilities: Course Director for Genetics; Interim Chair, Department of Biochemistry and Molecular Pharmacology

 

RESEARCH INTERESTS:
We study homologous recombination (HR) and DNA repair.  HR occurs in all life forms and is an important mechanism for the repair of damaged chromosomes, for rescuing collapsed replication forks, for maintaining telomeres in the absence of telomerase, and for insuring that chromosome pairs segregate correctly during meiosis. While HR is essential to many processes, too much HR is also deleterious, leading to chromosome rearrangements and general genomic instability. We use the yeast Saccharomyces cerevisiae to study how DNA damage arises and is recognized, how recombination is regulated and what are the key proteins that limit HR.

 

SELECTED PUBLICATIONS

LAB MEMBERS:
Anastasiya Epshtein, Research Technician