James Borowiec

James A. Borowiec, Ph.D.
Professor, Department of Biochemistry and Molecular Pharmacology
550 First Avenue
Dept. of Biochemistry Floor 3 Room 359
Medical Science Building
New York, NY 10016
Office : 212-263-8453, 212-263-8454
Fax : 212-263-8166
Email : James.Borowiec@nyumc.org 

Cancer, DNA replication, DNA damage and repair, cell cycle, genotoxic stress, replication protein A


Graduate Education: PhD in Chemistry and Biochemistry at UCLA (1986)
Postdoctoral Training: Memorial Sloan-Kettering Cancer Center (1986-1989)
Academic Appointments: 1989-1996 Assistant Professor, Department of Biochemistry
1996-2005 Associate Professor, Department of Biochemistry
2005-2011 Professor, Department of Biochemistry
2012-present Professor, Department of Biochemistry and Molecular Pharmacology,

Major Responsibilities:
Associate Director, Sackler Institute of Graduate Biomedical Sciences Course Director, Foundations of Cell and Molecular Biology Member, American Cancer Society Institution Grant Review Board Editorial Board, DNA & Cell Biology

Genotoxic stresses that damage the chromosomal DNA or inhibit the progression of a DNA replication fork can lead to instability of the genetic information and hence cause cellular transformation. One key factor that both signals the presence of genotoxic stress and serves to minimize DNA damage is RPA, the eukaryotic single-stranded DNA-binding protein. A focus of our research is to understand the roles of RPA in enhancing genomic stability during DNA replication, and DNA double-strand breaks.


Alex Xu, Research Associate