Mamta Tahiliani

Mamta Tahiliani, Ph.D.
Assistant Professor, Department of Biochemistry and Molecular Pharmacology
Skirball, 4-4
540 First Avenue, New York, NY 10016
Office:  (212) 263-2854
Lab: (646) 501 6955
Email: Mamta.Tahiliani@med.nyu.edu

Lab Website

KEY INTERESTS:
epigenetics, DNA methylation, modified bases, stem cells, genomic integrity

BIOGRAPHICAL DETAILS:

Graduate Education:  PhD in Endocrinology at Harvard Medical School (2009)
Postdoctoral Training:  Harvard Medical School (2009-2010)
Academic Appointments: 2011: Assistant professor in Biochemistry

RESEARCH INTERESTS:
The Tahiliani Lab is interested in understanding how DNA methylation influences genomic regulation. It has been appreciated for a long time that cancer cells exhibit altered methylation patterns compared to normal cells. We have discovered that the cancer associated TET enzymes catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). We found that hmC is enriched in the genome of mouse ES cells and declines when ES cells are differentiated. We are now focused on integrating hmC into known pathways of 5mC metabolism and want to determine how hmC exerts its influence on the genome with the ultimate goal of understanding the role that 5mC and hmC play in genomic stability.

SELECTED PUBLICATIONS

LAB MEMBERS:
Yannick Delpu, Post-doc
Evgenia Korol, Graduate Student
Shirin Mortazavi, Graduate Student
Alma Sanchez, Administrative Assistant