Tony Huang

Tony T. Huang, Ph.D.
Associate Professor, Department of Biochemistry and Molecular Pharmacology
Medical science Building, Room 399
550 First Avenue, New York, NY10016
Office:  212-263-9046
Tel Lab: 212-263-9281
Email: Tony.Huang@nyumc.org

KEY INTERESTS:
Fanconi anemia, DNA repair, cancer, DUBs, reversible ubiquitination

BIOGRAPHICAL DETAILS:
Graduate Education: PhD in Molecular Cellular Pharmacology at University of Wisconsin-Madison (2003)
Postdoctoral Training: Dana-Faber Cancer Institute, Harvard Medical School (2003-2006)
Academic Appointments: 2006: Assistant professor in Biochemistry
Major Responsibilities: Course Director for Principles of Protein Modifications in Health and Disease
Graduate Advisor for Molecular Oncology Tumor Immunology (MOTI) Sackler Graduate Program

RESEARCH INTERESTS:
Monoubiquitination is a highly regulated process conserved in all eukaryotes that controls a broad range of cellular functions, from immune response, vesicle trafficking, to DNA repair. Like protein phosphorylation, monoubiquitination is a dynamic and reversible post-translational process whereby an enzyme cascade conjugates ubiquitin to a target protein, and a family of enzymes, the deubiqutinases (DUBs), are potent at removing this modification. Two important DNA repair pathways are “switched on” by monoubiquitination: the Fanconi Anemia cancer susceptibility/chromosome instability pathway and the translesion DNA synthesis pathway. Research projects in my lab will include the characterization and elucidation of signaling mechanisms surrounding DUB activation and inactivation and how these molecular events contribute to the maintenance of genome integrity. Disruption of these pathways will ultimately lead to failed DNA repair, genome instability and cancer.

SELECTED PUBLICATIONS

LAB MEMBERS:
HuiLan Hu, Postdoctoral Fellow
Kate Coleman, Postdoctoral Fellow
Peter Tonzi, MSTP Graduate Student
Stephanie Patchett, Postdoctoral Fellow
Zarah Aziz, Research Technician