Shohei Koide

Shohei Koide, PhD

Professor, Biochemistry and Molecular Pharmacology Department
Alexandria Center for Life Sciences, Suite 625
430 East 29th Street, New York, NY  10016
Office:  646-501-4601
Lab:  646-501-4602

Key Interests

Protein design and engineering, Drug discovery, Protein-protein interaction, Cellular signaling, Structural biology, Synthetic biology

Biographical Details

Graduate Education:               PhD in Agricultural Chemistry, University of Tokyo (1991)
Postdoctoral Training:             The Scripps Research Institute (1991-1995)
Academic Appointments:         1995 - Assistant professor of Biochemistry and Biophysics, University of Rochester
                                                 School of Medicine
                                                 2001 - Associate professor of Biochemistry and Biophysics, University of Rochester
                                                 School of Medicine
                                                 2002 - Associate professor of Biochemistry and Molecular Biology, University of
                                                 2010 - Professor of Biochemistry and Molecular Biology, University of Chicago
                                                 2016 - Professor of Biochemistry and Molecular Pharmacology, NYU School of

Major Responsibilities

Director of Cancer Biologics, Laura and Isaac Perlmutter Cancer Center

Research Interests

Our research focuses on elucidating the mechanisms underlying protein-protein interactions using "synthetic" approaches, i.e. the design and engineering of protein recognition interfaces.  Our research is multi-disciplinary, integrating rational design, directed evolution, structural and cellular biology.  By utilizing "synthetic binding proteins" as uniquely powerful tools, we achieve high-precision control of cellular regulatory machineries, particularly those governed by allostery and/or post-translational modification, e.g. phospho-signaling, epigenetics and membrane proteins.  As Director of Cancer Biologics at the Perlmutter Cancer Center, I aim to develop anti-cancer therapeutics and novel tools for cancer biology investigation.

Lab Members

Gabriel Salzman, MD/PhD student (at University of Chicago)
Kohei Kurosawa, Postdoctoral Fellow
Ankit Gupta, Associate Research Scientist
Akiko Koide, Research Assistant Professor
Linxiao Chen, Postdoctoral Fellow
Eric Denbaum, Research Technician
Steven Tsai, Research Technician
Tanya Panchenko, Senior Research Scientist
Takamitsu Hattori, Senior Research Scientist

Lab Website