Publications

Joseph, G.A., Lu, M., Radu, M., Lee, J.K., Burden, S.J., Chernoff, J., Krauss R.S. 2017. Group I Paks promote skeletal myoblast differentiation in vivo and in vitro. Molecular and Cellular Biology 37: 216-222.  

Remedio, L., Gribble, K.D., Lee, J.K., Kim, N., Hallock, P.T., Delestree, N., Mentis, G.Z., Froemke, R.C., Granato, M., Burden, S.J. 2016. Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes and Development 30:1058-1069

Burden, S.J., Hubbard, S.R., Zhang, W., and Yumoto, N. The MuSK receptor family. In: Receptor Tyrosine Kinases: Family and Subfamilies, Wheeler, D. and Yarden, Y. eds. Springer-Verlag, pp. 359-372.

Gomez, A.M., Froemke, R.C. and Burden, S.J. 2014. Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. eLife 3:e04287

Burden, S.J., Yumoto, N. and Zhang, W. 2013. The role of MuSK in synapse formation and neuromuscular disease. Cold Spring Harb. Perspect. Biol. 5:a009167.

Huijbers, M.G., Zhang, W., Klooster, R., Niks, E.H., Friese, M.B., Straasheijm, K.R., Thijssen P.E., Vrolijk, H., Plomp, J.J., Vogels, P., Losen, M., van der Maarel, S.M., Burden, S.J. and Verschuuren, J.J. 2013. MuSK IgG4 auto-antibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4, Proc. Natl. Acad. Sci. USA, 110:20783-20788.

Yumoto, N., Kim, N. and Burden, S.J. 2012. Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses. 2012. Nature. 489:438-442.

Perez-Garcia, M.J. and Burden, S.J. 2012. Increasing MuSK activity delays denervation and improves motor function in ALS mice. 2012. Cell Reports 2:497-502.

Burden, S.J. and Scheiffele, R.O.L. 2012. Synapse Formation. In: Fundamental Neuroscience, Acad. Press, pp. 385-403.

Mazzon, C., et al. 2012. Agrin is required for survival and function of monocytic cells. 2012. Blood 119:5502-5511.

Gomez, A. and Burden, S.J. 2011. The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation. 2011. Dev. Dyn. 240:2626-2633.
 
Zhang, W., Coldefy, A.S., Hubbard, S.R. and Burden, S.J. 2011. Agrin binds to the N-terminal region of Lrp4 and stimulates association between Lrp4 and the first Ig-like domain in MuSK. J. Biol. Chem. 286:40624-40630.

Burden, S.J. 2011. SnapShot: Neuromuscular Junction. 2011. Cell144:826-826.e1.
 
Hara, Y. et al. 2011. Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection. Proc. Natl. Acad. Sci. USA, 108:17426-17431.
 
Banerjee, S., Gordon, L., Donn, T.M., Berti, C., Moens, C.B., Burden, S.J. and Granato, M. 2011 A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development 138:3287-3296.
 
Mazzon, C., Anselmo, A., Cibella, J., Soldani, C., Destro, A., Kim, N., Roncalli, M., Burden, S.J., Dustin, M.L., Sarukhan, A. and Viola, A. 2011. Agrin is a novel non-redundant player of the hematopoietic stem cell niche. Blood 118:2733-2742.

Hara, Y., et al. 2011. A dystroglycan mutation associated with limb-girdle dystrophy. N. Engl. J. Med. 364:939-946.

Hallock, P.T., Xu, C.F., Park, T.J., Neubert, T.A., Curran, T. and Burden, S.J. 2010. Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes and Development 24:2451-2461.

Bergamin, E., Hallock, P.T., Burden, S.J., and Hubbard, S.R. 2010. The cytoplasmic adapter protein Dok-7 activates the receptor tyrosine kinase MuSK via dimerization. Mol. Cell 39:100-109.

Stiegler, A.L., Burden, S.J, and Hubbard, S. 2009. Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J. Mol. Biol. 393:1-9.

Ruggiu, M., Herbst, R., Kim, N., Jevsek, M., Fak, J.J., Mann, M.A., Fischbach, G., Burden, S.J. and Darnell, R.B. 2009. Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc. Natl. Acad. Sci. USA 106:3513-3518.

Kim, N., Stiegler, A.L., Cameron, T.O., Hallock, P.T., Gomez, A.M., Huang, J.H., Hubbard, S.R., Dustin, M.L. and Burden, S.J. 2008. Lrp4 is a receptor for agrin and forms a complex with MuSK. Cell 135:334-342.

Borges, L.S., Yechikhov, S., Lee, Y.I., Rudell, J.B., Friese, M.B., Burden, S.J. and Ferns, M.J. 2008. Identification of a motif in the actylcholine receptor beta subunit whose phosphoryalton regulates rapsyn association and postsynaptic receptor localization. J. Neuroscience 28:11468-11476.

Mansilla, F., Dominquez, C.A., Yeadon, J.E., Corydon, T.J., Burden, S.J. and and Knudsen, C.R. 2008. Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. J. Cellular Biochemistry 105:847-858.

Kim, N. and Burden, S.J. 2008. MuSK controls where motor axons grow and form synapses. Nature Neuroscience 11:19-27.

Friese, M.B., Blagden, C.S. and Burden, S.J. 2007. Synaptic differentiation is defective in mice lacking acetylcholine receptor beta subunit tyrosine phosphorylation. Development 134:4167-4176.

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S.J., Di Lisi, R., Sandri, C., Zhao, J., Goldberg, A.L., Schiaffino, S. and Sandri, M. 2007. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metabolism 6:458-471.

Jones, N., Hardy, W.R., Friese, M.B., Jorgensen, C., Smith, M.J., Woody, N.N., Burden, S.J., and Pawson, T. 2007. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with Muscle-Specific Kinase (MuSK). Mol. Cell. Biol. 27:4759-4773.

Jaworski, A., Smith, C.L. and Burden, S.J. 2007. GA-binding protein is dispensable for neuromuscular synapse formation and synapse-specific gene expression. Mol. Cell. Biol. 27:5040-5046.

Stiegler, A.L., Burden, S.J., and Hubbard, S.R. 2006. Crystal structure of the Agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. J. Mol. Biol. 364:424-433.

Jevesk, M., Jaworski, A., Polo-Parada, L., Kim, N., Fan, J., Landmesser, L.T., and Burden, S.J. 2006. CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc Natl Acad Sci USA. 103: 6374-6379.

Jaworski, A. and Burden, S.J. 2006. Neuromuscular synapse formation in mice lacking neuron- and skeletal muscle-derived Neuregulin-1. J. Neurosci. 26:655-661.

Wang, X., Blagden, C., Fan, J., Nowak, S., Taniuchi, I., Littman, D.R. and Burden, S.J. 2005. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes & Development 19:1715-1722.

Mittaud, P., Camilleri, A.A., Willmann, R., Erb-Vogtli, S., Burden, S.J. and Fuhrer, C. 2004. A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors. Mol. Cell. Biol. 24:7841-7854.

Rimer, M., Prieto, A.L., Weber, J.L., Colasante, C., Ponomareva, O., Fromm, L., Schwab, M.H., Lai, C. and Burden, S.J. 2004. Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. Mol. Cell. Neurosci. 16:271-281.

Blagden, C.S., Fromm, L. and Burden, S.J 2004. Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87. Mol. Cell. Biol. 24:1983-1989.

Burden SJ, Fuhrer C, Hubbard SR.2003. Agrin/MuSK signaling: willing and Abl. Nat Neurosci. 6:653-654.

Hippenmeyer, S., Shneider, N.A., Birchmeier, C., Burden, S.J., Jessell, T.M. and Arber, S. 2002. A role for Neuregulin-1 signaling in muscle spindle differentiation. Neuron 36:1035-1049.

Herbst, R., Avetisova, E. and Burden, S.J. 2002. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development 129:5449-5460.

Watty, A. and Burden, S.J. 2002. N-linked glycosylation of MuSK restrains ligand-independent MuSK activation and AChR clustering. J. Biol. Chem. 277:50457-50462.

Burden, S.J., Berg, D.K. and O�Leary, D.M. 2002. Target selection and synapse formation. In: Fundamental Neuroscience, Acad. Press, pp. 469-498.

Wredenberg, A., Wibom, R., Wilhelmsson, H., Graff, C., Wiener, H.H., Burden, S.J., Oldfors, A., Westerblad, H. and Larsson, N.G. 2002. Increasedmitochondrial mass in mitochondrial myopathy mice. Proc. Natl. Acad. Sci. USA 99:15066-15071.

Arber, S., Burden, S.J. and Harris, A.J. 2002. Patterning of skeletal muscle. Curr. Opin. Neurobiol. 12:100-103.

Burden, S.J. 2002. Building the vertebrate neuromuscular synapse. J. Neurobiol. 53:501-511.

Yang, X., Arber, S., William, C., Li, L., Tanable, Y., Jessell, T.M., Birchmeier, C. and Burden, S.J. 2001. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron 30:399-410.

Fromm, L. and Burden, S.J. 2001. Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells. Biochemistry 40:5306-5312.

Smith, C.L., Mittaud, P., Prescott , E.D., Fuhrer, C. and Burden, S.J. 2001. Src, Fyn and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J. Neuroscience 21:3151-3160.

Watty, A., Neubauer, G., Dreger, M., Zimmer, M., Wilm, M. and Burden, S.J. 2000. The in vitro and in vivo phosphotyrosine map of activated MuSK. Proc. Natl. Acad. Sci. USA. 97:4585-4590.

Bothe, G.W.M., Haspel, J.A., Smith, C.L., Wiener, H.H. and Burden, S.J. 2000. Selective expression of Cre recombinase in skeletal muscle fibers. Genesis 26:165-166.

Burden, S.J. 2000. Wnts as retrograde signals for axon and growth cone differentiation. Cell 100:495-497.

Herbst, R. and Burden, S.J. 2000. The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. EMBO J. 19:67-77.

Yang, X., Li, W., Prescott , E.D., Burden, S.J., and Wang, J.C. 2000. DNA topoisomerase IIb and neural development. Science 287:131-134.

Lichtman, J.W., Burden, S.J., Culican, S.M. and Wong, R.O.L. 1999. Synapse formation and elimination. In: Fundamental Neuroscience, Acad. Press, pp. 547-580.

Fromm, L. and Burden, S.J. 1998. Transcriptional pathways for synapse-specific, neuregulin-induced and electrical activity-dependent transcription. J. Physiol. ( Paris ) 92:173-176.

Fromm, L. and Burden, S.J. 1998. Synapse-specific and neuregulin-induced transcription require an Ets site that binds GABPa/GABPb. Genes and Development 12:3074-3083.

Rimer, M., Cohen, I. , L�mo, T., Burden, S.J., and McMahan, U.J. 1998. Neuregulins and erbB receptors at neuromuscular junctions and at agrin-induced postsynaptic-like apparatus in skeletal muscle. Mol. Cell. Neurosci. 12:1-15.

Burden, S.J. 1998. The formation of neuromuscular synapses. Genes and Development 12:133-148.

Burden, S.J. and Yarden, Y. 1996. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18:847-855.

Glass, D.J., Bowen , D.C. , Radziejewski, C., Bruno. J., Stitt, T.N., Ryan, T.E., Gies, D.R., Mattsson, K., Shah, S., Burden, S.J., Valenzuela, D.M., DeChiara, T.M., and Yancopoulos, G.D. 1996. Agrin acts vis a MuSK receptor complex. Cell 85:513-523.

DeChiara, T.M., Bowen , D.C. , Valenzuela, D.M., Simmons, M.V., Poueymirou, W.T., Thomas, S., Kinetz, E., Compton , D.L., Park, J.S., Smith, C., DiStefano, P.S., Glass, D.J., Burden, S.J. and Yancopoulos, G.D. 1996. The receptor tyrosine kinase, MuSK, is required for neuromuscular junction formation in vivo. Cell 85:501-512.

Zhu, X., Lai, C., Thomas, S. and Burden, S.J. 1995. Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses. EMBO J. 14:5842-5848.

Valenzuela, D.M., Stitt, T.N., DiStefano, P.S., Rojas, E., Mattsson, K., Compton, D.L., Lunez, L., Park, J.S., Stark, J.L., Gies, D.R., Thomas, S., Copeland, N.G., Jenkins, N.A., Burden, S.J., Glass, D.J. and Yancopoulos, G.D. 1995. Identification of a receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction and after injury. Neuron 15:573-584.

Carraway, K.L. III and Burden, S.J. Neuregulins and their receptors. 1995. Curr. Opin. Neurobiol. 5:606-612.

Currie, D.A. Truman, J.W. and Burden, S.J. 1995. Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers. Dev. Dyn. 203:311-316.

Burden, S.J., Jo, S.A., Tang, J., Zhu, X., Yeadon, J.E. and Simon, A.M. 1995. Polarity in skeletal muscle cells is induced by innervation. Seminars in Develop. Biol. 6:59-65.

Jo, S.A., Zhu, X., Marchionni, M. A. and Burden, S.J. 1995. Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature 373:158-161.

Zhu, X., Yeadon, J.E. and Burden, S.J. 1994. AML1 is expressed in skeletal muscle and is regulated by innervation. Mol. Cell. Biol. 14:8051-8057.

Tang, J., Jo, S.A. and Burden, S.J. 1994. Separate pathways for synapse-specific and electrical activity-dependent gene expression in skeletal muscle. Development 120:1799-1804.

Simon, A.M. and Burden, S.J. 1993. An E-box mediates activation and repression of the AChRd-subunit gene during myogenesis. Mol. Cell. Biol. 13:5133-5140.

Jennings, C.G.B., Dyer, S.M. and Burden, S.J. 1993. Muscle-specific, trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases. Proc. Natl. Acad. Sci. USA 90:2895-2899.

Dutton, E.K., Simon, A.M. and Burden, S.J. 1993. Electrical activity-dependent regulation of the AChRd subunit gene, MyoD and myogenin in cell culture. Proc. Natl. Acad. Sci. USA 90:2040-2044.

Jennings, C.G.B. and Burden, S.J. 1993. Development of the neuromuscular junction. Curr. Opin. in Neurobiol. 3:75-81.

Burden, S.J. Synapse-specific gene expresssion. 1993. Trends in Genetics 9:12-16.

Jo, S.A. and Burden, S.J. 1992. Synaptic basal lamina contains a signal for synapse-specific transcription. Development 115:673-680.

Simon, A.M., Hoppe, P., and Burden, S.J. 1992. Spatial restriction of AChR gene expression to subsynaptic nuclei. Development 114:545-553.

Ravin, A.J., Dyer, S.M., Yeadon, J.E. and Burden, S.J. 1991. Multiple dystrophin isoforms are associated with the postsynaptic membrane of Torpedo electric organ. J. Physiol. (Paris) 85:131-133.

Yeadon, J.E., Lin, H., Dyer. S.M. and Burden, S.J. 1991. Dystrophin is a component of the subsynaptic membrane. J. Cell Biol. 115:1069-1076.

Simon, A.M., Dutton, E.K., and Burden, S.J. 1991. Regulation of acetylcholine receptor gene expression. In: Molecular Approaches to Drug Abuse Research: Receptor cloning, neurotransmitter expression and molecular genetics. NIDA Research Monograph 111. Lee, T.N.H. ed. vol.1, pp. 24-27.

Quantum mechanics of synapses. Burden SJ, McKay RD Cell 1990 Oct 5 63:1 7-8.

Muscle-specific gene expression controlled by a regulatory element lacking a MyoD1-binding site [published erratum appears in Nature 1990 May 24;345(6273):364] Baldwin TJ, Burden SJ Nature 1989 Oct 26 341:6244 716-20.

Baldwin, T.J. and Burden, S.J. 1989. Myotube-specific expression of the mouse AChR delta subunit gene is conferred by 148 bp of 5' flanking DNA. In: Molecular Biology of Neuroreceptors and Ion Channels. Maelicke, A. ed. pp. 519-540. Springer-Verlag. Berlin.

Baldwin, T.J. and Burden, S.J. 1988. Isolation and characterization of the mouse acetylcholine receptor delta subunit gene: identification of a 148-bp cis-acting region that confers myotube-specific expression. J. Cell Biol. 107:2271-2279.

Baldwin, T.J., Theriot, J.A., Yoshihara, C.M., and Burden, S.J. 1988. Regulation of transcript encoding the 43 kd subsynaptic protein during development and after denervation. Development 104:557-564.

Baldwin, T.J., Yoshihara, C.M., Blackmer, K., Kintner, C.R., and Burden, S.J. 1988. Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis. J. Cell Biol. 106:469-478.

Burden, S.J. 1988. Subsynaptic proteins at nerve-muscle synapses. In: From Message to Mind. Easter, S.S., Barald, K.F., and Carlson, B.M eds. pp. 23-28. Sinauer Assoc., Inc.

Woodruff, M.L., Theriot, J., and Burden, S.J. 1987. 300-kD subsynaptic protein copurifies with acetylcholine receptor-rich membranes and is concentrated at neuromuscular synapses. J. Cell Biol. 104:939-946.

Burden, S.J. 1987. The extracellular matrix and subsynaptic sarcoplasm at nerve-muscle syapses. In: The Vertebrate Neuromuscular Junction. Salpeter, M.M. ed. pp. 163-186. New York: Alan R. Liss.

Burden, S.J. 1985. The subsynaptic 43-kDa protein is concentrated at developing nerve-muscle synapses in vitro. Proc. Natl. Acad. Sci. USA 82:8270-8273.

Burden, S.J., DePalma, R.L., and Gottesman., G.S. 1983. Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the b-subunit and the 43 kd subsynaptic protein. Cell 35:687-692.

Burden, S.J. 1982. Identification of an intracellular postsynaptic antigen at the frog neuromuscular junction. J. Cell Biol. 94:521-520.

Burden, S.J. 198l. Monoclonal antibodies to the frog nerve-muscle synapse. In: Monoclonal Antibodies to Neural Antigens. McKay, R., Raff, M.C., and Reichardt, L.F. eds. Cold Spring Harbor publications. Cold Spring Harbor, NY.

McMahan, U.J., Sargent, P.B., Rubin, L.L., and Burden, S.J. 1980. Factors that influence the organization of acetylcholine receptors in regenerating muscle are associated with the basal lamina at the neuromuscular junction. In: Ontogenesis and Functional Mechanisms of Peripheral Synapses. Taxi, J. ed. Elsevier/North-Holland Biomedical Press.

Burden, S.J., Sargent, P.B., and McMahan, U.J. 1979. Acetylcholine receptors in regenerating muscle accumulate at the original synaptic site in the absence of the nerve. J. Cell Biol. 82:412-425.

Burden, S. 1977. What regulates the acetylcholine receptor? Soc. Nerosci. Symp. 7:2l-27.

Burden, S. 1977. Acetylcholine receptors at the neuromuscular junction: developmental change in receptor turnover. Devel. Biol. 61:79-85.

Burden, S. 1977. Development of the neuromuscular junction in the chick embryo: the number, distribution and stability of acetylcholine receptors. Devel. Biol. 57:317-329.

Burden, S.J., Hartzell, H.C., and Yoshikami, D. 1975. Acetylcholine receptors at neuromuscular synapses: Phylogenetic differences detected by snake-neurotoxins. Proc. Natl. Acad. Sci. USA 72:3245-3249.