Matthias Stadtfeld, PhD

Assistant Professor; Skirball Institute of Biomolecular Medicine, Developmental Genetics. Department of Cell Biology

Stadtfeld Lab

Cell Biology

Cell Biology, Skirball Institute of Biomolecular Medicine


Contact Information

540 First Avenue
Skirball Institute of Biomolecular Medicine
Floor 4, Lab 1
New York, NY 10016

Office Tel: (646) 501-6750
Lab Tel: (646) 501-6751
Fax: (212) 263-7760

Admin Contact

Anne Ng
Tel: (212) 263-8573

Reprogramming and mammalian stem cells

Pluripotent cells that have the unique ability to form all cell types of the adult body can be derived in two different ways: 1) by explanting early mammalian embryos,thereby giving rise to embryonic stem (ES) cells and 2) by the enforced expression of defined embryonic transcription factors in adult somatic cells, giving rise to induced pluripotent stem (iPS) cells. The latter process is commonly referred to as reprogramming and allows for the comparatively straightforward generation of patient-specific pluripotent stem cells to study, and ultimately possibly treat, degenerative disorders. In addition, iPSC technology represents a tractable experimental approach to study mammalian development.

Research in my laboratory uses reprogramming technology to identify mechanisms that control gene expression and determine cellular identity, using the mouse as the main model organism. We are working towards a better understanding of the process of induced pluripotency on a cellular and molecular level, including the coordination of remodeling events during reprogramming and the reasons for the occurrence of epigenetic abnormalities in iPS cells. A second major goal is using pluripotent cells for the in vitro generation of adult-type stem cells that are functionally equivalent to their in vivo counterparts found in the body. We are especially interested in understanding the molecular determinants ofblood cell specification and, ultimately, the generation of functional hematopoietic stem cells from ES cells and iPS cells. Finally, we are interested in the molecular regulation of genomic imprinting and the role of imprinted genes in adult stem cells.