Seth J. Orlow, MD, PhD

Professor; Samuel Weinberg Professor of Pediatric Dermatology; Departments of Dermatology (Chair), Cell Biology and Pediatrics (Admin)

Cell Biology, Dermatology

Development of Novel Targeted Therapeies in Melanoma and other Cancers, Molecular and Cellular Basis of Pigmentation




Contact Information

240 East 38th Street
Ambulatory Care Center
New York, NY 10016

Tel: 212-263-5313

Research Summary

  1. Development of novel therapeutics for the treatment of a number of cancers including melanoma and multiple myeloma, as well as unraveling pathways underlying chemoresistance in these tumors. To do so, we utilize small molecule screening of already-approved drugs ("drug repositioning") and of natural products combined with molecular and cellular techniques.
  2. Understanding the cell biology of melanin synthesis and deposition in the skin, hair and eyes, including the processing and trafficking of tyrosinase, the rate-limiting enzyme in melanin production, as well as the pathogenesis of various forms of oculocutaneous albinism that diminish pigmentation. 3. Elucidating the pathogenesis of vitiligo, in which melanocytes in the skin are destroyed, including the role of endoplasmic reticulum stress and the unfolded protein response.