The Oxytocin U19 BRAIN Initiative Grant is led by investigators in NYU Langone’s Neuroscience Institute working to demonstrate how oxytocin moderates social behaviors. See our latest events, news, and publications to learn more.

Events

Events associated with the Oxytocin U19 BRAIN Initiative Grant give the neuroscience community an opportunity to learn about our work and hear from experts in the field.

FAIR Thee Well: The Language and Tools for Sharing Neurophysiological Data
August 9–10, 2021

As neuroscience becomes an increasingly collaborative discipline, use of a common language to describe data is essential for collaboration, open science, reproducibility, and the access of scientific data in the broader community. The National Institutes of Health (NIH) have also created new requirements for data sharing to accelerate scientific discovery and expedite translation of results into knowledge, products, and procedures to improve human health.

Our virtual symposium “FAIR Thee Well: The Language and Tools for Sharing Neurophysiological Data” discussed challenges and solutions for sharing data and provided an overview of the tools and languages that make data findable, accessible, interoperable, and reusable (FAIR).

This symposium was organized by NYU Langone’s Neuroscience Institute and was made possible thanks to the following funding from the NIH: Oxytocin Modulation of Neural Circuit Function and Behavior (5U19NS107616-03), The Diverse Neuroscientists Doctoral Training Series (5R25NS107178-03), and Integrative Approaches to Explore Cellular Interactions in Neural Circuits Training Program (5 T32 NS086750-07).

News

Robert Froemke, PhD, was awarded the Landis Award for Outstanding Mentorship from the National Institute of Neurological Disorders and Stroke (NINDS). In addition, he and members of his lab were featured in Smithsonian Magazine for their work on oxytocin.

György Buzsáki, MD, PhD, received the Society for Neuroscience Ralph W. Gerard Prize in Neuroscience for outstanding contributions to neuroscience throughout his career. To read more about Dr. Buzsáki’s work, read his latest feature published in the June 2022 issue of Scientific American.

Dayu Lin, PhD, identified a population of cells in the posterior amygdala as an integral component for male aggression and sexual behavior.

Featured Research Publications

Ebbesen CL, Froemke RC. Automatic mapping of multiplexed social receptive fields by deep learning and GPU-accelerated 3D videography. Nat Comm. 2022. DOI.

Zutshi I, Valero M, Fernández-Ruiz A, Buzsáki G. Extrinsic control and intrinsic computationin the hippocampal CA1 circuit. Neuron. 2022. DOI.

Valero M, Zutshi I, Yoon E, Buzsáki G. Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics. Science. 2022. DOI.

Liu JJ, Tsien RW, and Pang ZP. Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity. Nat Neurosci. 2022. DOI.

Opendak M, Raineki C, Perry RE, Rincón-Cortés M, Song SC, Zanca RM, Wood E, Packard K, Hu S, Woo J, Martinez K, Vinod KY, Brown RW, Deehan GA, Froemke RC, Serrano PA, Wilson DA, Sullivan RM. Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala. Neuron. 2021. DOI.

Halvorsen M, Gould L, Wang X, Grant G, Moya R, Rabin R, Ackerman MJ, Tester DJ, Lin PT, Pappas JG, Maurano MT, Goldstein DB, Tsien RW, Devinsky O. De novo mutations in childhood cases of sudden unexplained death that disrupt intracellular Ca2+ regulation. Proc Natl Acad Sci USA. 2021. DOI.

Tingley D, McClain K, Kaya E, Carpenter J, Buzsáki G. A metabolic function of the hippocampal sharp wave-ripple. Nature. 2021. DOI.

Park C, Chen C, Tian CL, Park GN, Chenouard N, Lee H, Yeo XY, Jung S, Tsien RW, Bi GQ, Park H. Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking. Proc Natl Acad Sci USA. 2021. DOI.

Petersen PC, Siegle JH, Steinmetz NA, Mahallati S, Buzsáki G. CellExplorer: A framework for visualizing and characterizing single neurons. Neuron. 2021. DOI.

Zhang Y, Cao L, Varga V, Jing M, Karadas M, Li Y and Buzsáki G. Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory. Proc Natl Acad Sci USA. 2021. DOI.

Fernández-Ruiz A, Oliva A, Soula M, Rocha-Almeida F, Nagy GA, Martin-Vazquez G and Buzsáki G. Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies. Science. 2021. DOI.

Carcea I, Caraballo NL, Marlin BJ, Ooyama R, Riceberg JS, Mendoza Navarro JM, Opendak M, Diaz VE, Schuster L, Alvarado Torres MI, Lethin H, Ramos D, Minder J, Mendoza SL, Bair-Marshall CJ, Samadjopoulos GH, Hidema S, Falkner A, Lin D, Mar A, Wadghiri YZ, Nishimori K, Kikusui T, Mogi K, Sullivan RM, Froemke RC. Oxytocin neurons enable social transmission of maternal behavior. Nature. 2021. DOI.

McKenzie S, Huszár R, English DF, Kim K, Christensen F, Yoon E and Buzsáki G. Preexisting hippocampal network dynamics constrain optogenetically induced place fields. Neuron. 2021. DOI.

Valero M, Viney TJ, Machold R, Mederos S, Zutshi I, Schuman B, Senzai Y, Rudy B and Buzsáki G. Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex. Nat Neurosci. 2021. DOI.

Rogers S, Rozman PA, Valero M, Doyle WK and Buzsáki G. Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells. Proc Natl Acad Sci U S A. 2021. DOI.

Chenouard N, Xuan F and Tsien RW. Synaptic vesicle traffic is supported by transient actin filaments and regulated by PKA and NO. Nat Commun. 2020. DOI.

Petersen PC and Buzsáki G. Cooling of medial septum reveals theta phase lag coordination of hippocampal cell assemblies. Neuron. 2020. DOI.

Li B, Suutari BS, Sun SD, Luo Z, Wei C, Chenouard N, Mandelberg NJ, Zhang G, Wamsley B, Tian G, Sanchez S, You S, Huang L, Neubert TA, Fishell G and Tsien RW. Neuronal inactivity co-opts LTP machinery to drive potassium channel splicing and homeostatic spike widening. Cell. 2020. DOI.

Field RE, D'amour JA, Tremblay R, Miehl C, Rudy B, Gjorgjieva J and Froemke RC. Heterosynaptic Plasticity determines the set point for cortical excitatory-inhibitory balance. Neuron. 2020. DOI.

Yamaguchi T, Wei D, Song SC, Lim B, Tritsch NX and Lin D. Posterior amygdala regulates sexual and aggressive behaviors in male mice. Nat Neurosci. 2020. DOI.

Falkner AL, Wei D, Song A, Watsek LW, Chen I, Chen P, Feng JE and Lin D. Hierarchical representations of aggression in a hypothalamic-midbrain circuit. Neuron. 2020. DOI.

Nitzan N, McKenzie S, Beed P, English DF, Oldani S, Tukker JJ, Buzsáki G and Schmitz D. Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway. Nat Commun. 2020. DOI.

Schiavo JK, Valtcheva S, Bair-Marshall CJ, Song SC, Martin KA and Froemke RC. Innate and plastic mechanisms for maternal behaviour in auditory cortex. Nature. 2020. DOI.

Tingley D and Buzsáki G. Routing of hippocampal ripples to subcortical structures via the lateral septum. Neuron. 2020. DOI.

Saadipour K, Tiberi A, Lombardo S, Grajales E, Montroull L, Mañucat-Tan NB, LaFrancois J, Cammer M, Mathews PM, Scharfman HE, Liao FF, Friedman WJ, Zhou XF, Tesco G and Chao MV. Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Mol Cell Neurosci. 2019. DOI.

Kuchibhotla KV, Hindmarsh Sten T, Papadoyannis ES, Elnozahy S, Fogelson KA, Kumar R, Boubenec Y, Holland PC, Ostojic S and Froemke RC. Dissociating task acquisition from expression during learning reveals latent knowledge. Nat Commun. 2019. DOI.

Glennon E, Carcea I, Martins ARO, Multani J, Shehu I, Svirsky MA and Froemke RC. Locus coeruleus activation accelerates perceptual learning. Brain Res. 2019. DOI.

Tirko NN, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC and Tsien RW. Oxytocin transforms firing mode of CA2 hippocampal neurons. Neuron. 2018. DOI.

Veras AB, Getz M, Froemke RC, Nardi AE, Alves GS, Walsh-Messinger J, Chao MV, Kranz TM and Malaspina D. Rare missense coding variants in oxytocin receptor (OXTR) in schizophrenia cases are associated with early trauma exposure, cognition and emotional processing. J Psychiatr Res. 2018. DOI.