Skirball Institute of Biomolecular Medicine Research Highlights by Year | NYU Langone Health

Skip to Main Content
Skirball Institute of Biomolecular Medicine Research Publications & Highlights Skirball Institute of Biomolecular Medicine Research Highlights by Year

Skirball Institute of Biomolecular Medicine Research Highlights by Year

Scientists at the Skirball Institute of Biomolecular Medicine have a history of making exciting biomedical discoveries. Read more about their research findings in recent years.

Research Highlights 2017

Cadwell Lab: “Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium” in Journal of Experimental Medicine

Postdoctoral fellow Amit Bhardwaj, working in the Smith Lab: “Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation” in Nature Communications

PhD student Michelle G. LeBlanc, working in the Lehmann Lab: “Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR” in Journal of Cell Biology

Postdoctoral fellow Olga Pekar, working in the Hubbard Lab: “Linking the environment, DAF-7/TGFβ signaling and LAG-2/DSL ligand expression in the germline stem cell niche” in Development

PhD student Juhee Pae, working in the Lehmann Lab: “GCL and CUL3 control the switch between cell lineages by mediating localized degradation of an RTK” in Developmental Cell

Treisman Lab: “COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation” in Development

Daniel J. Luciano, MD, working in the Belasco Lab: “A novel RNA phosphorylation state enables 5’ end-dependent degradation in Escherichia coli in Molecular Cell

Stokes Lab: “Crystal structure of the potassium-importing KdpFABC membrane complex” in Nature

Schwab Lab: “Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells” in Nature

Gan Lab: “REM sleep selectively prunes and maintains new synapses in development and learning” in Nature Neuroscience

PhD student Ekta Tripathi, working in the Smith Lab: “Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution” in The EMBO Journal

Froemke Lab: “Dynamics of auditory cortical activity during behavioural engagement and auditory perception” in Nature Communications

Ringstad Lab: “Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels” in eLife

Belasco Lab: “Identification of the RNA pyrophosphohydrolase RppH of Helicobacter pylori and global analysis of its RNA targets” in Journal of Biological Chemistry

PhD student Aaron F. Phillips, working in the Sfeir Lab: “Single-molecule analysis of mtDNA replication uncovers the basis of the common deletion” in Molecular Cell

Lehmann Lab: “Quantitative differences in a single maternal factor determine survival probabilities among Drosophila germ cells” in Current Biology

Froemke Lab: “Parallel processing by cortical inhibition enables context-dependent behavior” in Nature Neuroscience. Read more about their findings in Medical News Today.

Schwab Lab: “Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response” in Nature Immunology

Lehmann Lab: “piRNA-mediated regulation of transposon alternative splicing in the soma and germ line” in Nature

Research Highlights 2016

Torres-Vázquez Lab: “Reck enables cerebrovascular development by promoting canonical Wnt signaling” in Development

Nance Lab: “Developmentally programmed germ cell remodelling by endodermal cell cannibalism” in Nature Cell Biology

Postdoctoral fellow Thomas Ryan Hurd, working in the Lehmann Lab: “Long Oskar controls mitochondrial inheritance in Drosophila melanogaster in Developmental Cell

PhD student Emily Swanzey, working in the Stadtfeld Lab: “A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells” in Development

Skolnik Lab and Hubbard Lab: “Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1” in eLife

Skolnik Lab: “Identification of PGAM5 as a mammalian protein histidine phosphatase that plays a central role to negatively regulate CD4+ T cells” in Molecular Cell

PhD student Alexandra M. Pinzaru, working in the Sfeir Lab: “Telomere replication stress induced by POT1 inactivation accelerates tumorigenesis” in Cell Reports

Chao Lab: “Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate” in eLife

PhD student Deepshika Ramanan, working in the Cadwell Lab: “Helminth infection promotes colonization resistance via type 2 immunity” in Science

Chao Lab and Froemke Lab: “A distributed network for social cognition enriched for oxytocin receptors” in The Journal of Neuroscience

Littman Lab: “The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring” in Science

Littman Lab: “Actin dynamics regulates dendritic cell-mediated transfer of HIV-1 to T cells” in Cell

Lehmann Lab: “Regulation of ribosome biogenesis and protein synthesis controls germline stem cell differentiation” in Cell Stem Cell

Research Highlights 2015

Postdoctoral fellow Willy D. Ramos-Perez, working in the Schwab Lab: “A map of the distribution of sphingosine 1-phosphate in the spleen” in Nature Immunology

Hubbard Lab: “Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle” in Development

Froemke Lab: “Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex” in Nature Neuroscience

Smith Lab: “Loss of ATRX suppresses resolution of telomere cohesion to control recombination in ALT cancer cells” in Cancer Cell

PhD student Danielle Nagelberg, working in the Knaut Lab: “Origin, specification, and plasticity of the great vessels of the heart” in Current Biology

Lehmann Lab: Drosophila germ granules are structured and contain homotypic mRNA clusters” in Nature Communications

Littman Lab: “Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages” in Nature Immunology

Wang Lab: “ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism” in Nature Structural & Molecular Biology

Suh Lab: “Nutrient sensor in the brain directs the action of the brain-gut axis in Drosophila in Neuron

PhD student Diana Klompstra, working in the Nance Lab: “An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity” in Nature Cell Biology

Schwab Lab: “CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance” in Cancer Cell. Learn more about how their findings suggest a new way to treat childhood leukemia.

Lehmann Lab: “ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation” in Nature Cell Biology. Learn more about how their findings show that mitochondria play an important role in stem cell development.

Hubbard Lab: “Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells” in Nature Communications

Froemke Lab: “Oxytocin enables maternal behaviour by balancing cortical inhibition” in Nature. Learn more about their discovery of the mechanism by which oxytocin helps mothers be responsive to their offspring’s needs.

Treisman Lab: Drosophila Vps4 promotes epidermal growth factor receptor signaling independently of its role in receptor degradation” in Development

Gan Lab: “Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity” in Nature

Cadwell Lab: “Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin” in Cell Host & Microbe

Sfeir Lab: “Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination” in Nature

Novick Lab: “Pathogenicity island-directed transfer of unlinked chromosomal virulence genes” in Molecular Cell

Chao Lab: “Definition of a bidirectional activity-dependent pathway involving BDNF and Narp” in Cell Reports

Research Highlights 2014

Stadtfeld Lab: “Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming” in Stem Cell Reports. Learn more about their discovery of a reliable and highly efficient method for making stem cells.

Cadwell Lab: “An enteric virus can replace the beneficial function of commensal bacteria” in Nature. Learn more about their finding that viruses play a role in keeping people healthy.

Cadwell Lab: “Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells” in Immunity

Novick Lab: “Precisely modulated pathogenicity island interference with late phage gene transcription” in Proceedings of the National Academy of Sciences of the United States of America

Smith Lab: “Persistent telomere cohesion triggers a prolonged anaphase” in Molecular Biology of the Cell

Research Highlights 2013

Belasco Lab: “Specificity of RppH-dependent RNA degradation in Bacillus subtilis in Proceedings of the National Academy of Sciences of the United States of America

Lehmann Lab: “A spindle-independent cleavage pathway controls germ cell formation in Drosophila in Nature Cell Biology

Sfeir Lab: “Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity” in Cell Reports

Smith Lab: “SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres” in Journal of Cell Science

Treisman Lab: “Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues” in Journal of Cell Science

Cadwell Lab: “A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection” in Cell Host & Microbe

Knaut Lab: “Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue” in Cell