Skirball Institute of Biomolecular Medicine Research Highlights by Year
Scientists at the Skirball Institute of Biomolecular Medicine have a history of making exciting biomedical discoveries. Read more about their research findings in recent years.
Research Highlights 2017
Cadwell Lab: “Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium” in Journal of Experimental Medicine
Postdoctoral fellow Amit Bhardwaj, working in the Smith Lab: “Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation” in Nature Communications
PhD student Michelle G. LeBlanc, working in the Lehmann Lab: “Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR” in Journal of Cell Biology
Postdoctoral fellow Olga Pekar, working in the Hubbard Lab: “Linking the environment, DAF-7/TGFβ signaling and LAG-2/DSL ligand expression in the germline stem cell niche” in Development
PhD student Juhee Pae, working in the Lehmann Lab: “GCL and CUL3 control the switch between cell lineages by mediating localized degradation of an RTK” in Developmental Cell
Daniel J. Luciano, MD, working in the Belasco Lab: “A novel RNA phosphorylation state enables 5’ end-dependent degradation in Escherichia coli” in Molecular Cell
Gan Lab: “REM sleep selectively prunes and maintains new synapses in development and learning” in Nature Neuroscience
PhD student Ekta Tripathi, working in the Smith Lab: “Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution” in The EMBO Journal
Froemke Lab: “Dynamics of auditory cortical activity during behavioural engagement and auditory perception” in Nature Communications
Belasco Lab: “Identification of the RNA pyrophosphohydrolase RppH of Helicobacter pylori and global analysis of its RNA targets” in Journal of Biological Chemistry
PhD student Aaron F. Phillips, working in the Sfeir Lab: “Single-molecule analysis of mtDNA replication uncovers the basis of the common deletion” in Molecular Cell
Lehmann Lab: “Quantitative differences in a single maternal factor determine survival probabilities among Drosophila germ cells” in Current Biology
Froemke Lab: “Parallel processing by cortical inhibition enables context-dependent behavior” in Nature Neuroscience. Read more about their findings in Medical News Today.
Schwab Lab: “Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response” in Nature Immunology
Lehmann Lab: “piRNA-mediated regulation of transposon alternative splicing in the soma and germ line” in Nature
Research Highlights 2016
Nance Lab: “Developmentally programmed germ cell remodelling by endodermal cell cannibalism” in Nature Cell Biology
Postdoctoral fellow Thomas Ryan Hurd, working in the Lehmann Lab: “Long Oskar controls mitochondrial inheritance in Drosophila melanogaster” in Developmental Cell
PhD student Emily Swanzey, working in the Stadtfeld Lab: “A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells” in Development
PhD student Alexandra M. Pinzaru, working in the Sfeir Lab: “Telomere replication stress induced by POT1 inactivation accelerates tumorigenesis” in Cell Reports
PhD student Deepshika Ramanan, working in the Cadwell Lab: “Helminth infection promotes colonization resistance via type 2 immunity” in Science
Chao Lab and Froemke Lab: “A distributed network for social cognition enriched for oxytocin receptors” in The Journal of Neuroscience
Littman Lab: “Actin dynamics regulates dendritic cell-mediated transfer of HIV-1 to T cells” in Cell
Lehmann Lab: “Regulation of ribosome biogenesis and protein synthesis controls germline stem cell differentiation” in Cell Stem Cell
Research Highlights 2015
Postdoctoral fellow Willy D. Ramos-Perez, working in the Schwab Lab: “A map of the distribution of sphingosine 1-phosphate in the spleen” in Nature Immunology
PhD student Danielle Nagelberg, working in the Knaut Lab: “Origin, specification, and plasticity of the great vessels of the heart” in Current Biology
Lehmann Lab: “Drosophila germ granules are structured and contain homotypic mRNA clusters” in Nature Communications
Littman Lab: “Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages” in Nature Immunology
Wang Lab: “ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism” in Nature Structural & Molecular Biology
PhD student Diana Klompstra, working in the Nance Lab: “An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity” in Nature Cell Biology
Schwab Lab: “CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance” in Cancer Cell. Learn more about how their findings suggest a new way to treat childhood leukemia.
Lehmann Lab: “ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation” in Nature Cell Biology. Learn more about how their findings show that mitochondria play an important role in stem cell development.
Hubbard Lab: “Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells” in Nature Communications
Froemke Lab: “Oxytocin enables maternal behaviour by balancing cortical inhibition” in Nature. Learn more about their discovery of the mechanism by which oxytocin helps mothers be responsive to their offspring’s needs.
Cadwell Lab: “Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin” in Cell Host & Microbe
Research Highlights 2014
Stadtfeld Lab: “Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming” in Stem Cell Reports. Learn more about their discovery of a reliable and highly efficient method for making stem cells.
Cadwell Lab: “An enteric virus can replace the beneficial function of commensal bacteria” in Nature. Learn more about their finding that viruses play a role in keeping people healthy.
Cadwell Lab: “Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells” in Immunity
Novick Lab: “Precisely modulated pathogenicity island interference with late phage gene transcription” in Proceedings of the National Academy of Sciences of the United States of America
Smith Lab: “Persistent telomere cohesion triggers a prolonged anaphase” in Molecular Biology of the Cell
Research Highlights 2013
Belasco Lab: “Specificity of RppH-dependent RNA degradation in Bacillus subtilis” in Proceedings of the National Academy of Sciences of the United States of America
Lehmann Lab: “A spindle-independent cleavage pathway controls germ cell formation in Drosophila” in Nature Cell Biology
Smith Lab: “SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres” in Journal of Cell Science
Treisman Lab: “Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues” in Journal of Cell Science