NYU Mass Spectrometry Core for Neuroscience | NYU Langone Health

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Skirball Institute of Biomolecular Medicine Research Facilities NYU Mass Spectrometry Core for Neuroscience

NYU Mass Spectrometry Core for Neuroscience

Funding from the National Institutes of Health (NIH) allows NYU to provide molecular neuroscientists with access to the latest mass spectrometry and proteomics technologies.

Using the NYU Mass Spectrometry Core for Neuroscience, neuroscientists are able to identify proteins of interest and observe modification of these proteins via processes such as phosphorylation, glycosylation, and proteolysis.

Our facility is equipped to perform functional proteomics studies to identify proteins involved in key signal transduction processes in neurons. Scientists also use our instruments to characterize protein–protein interactions by surface plasmon resonance.

Ongoing Projects

Scientists using our mass spectrometry core lead a range of research projects that aim to characterize proteins responsible for key neuronal processes or disorders. Their ongoing projects include the following:

  • Steven J. Burden, PhD: the role of signaling by MuSK in the neuromuscular synapse; protein clustering at the neuromuscular synapse
  • Moses V. Chao, PhD: neurotrophin signaling
  • Mitchell Chesler, MD, PhD: dynamics and effects of pH regulation in the brain
  • David T. Chiu, MD: neuroregeneration
  • Matthew Dalva, PhD (Thomas Jefferson University): ephrin phosphoproteomics
  • Jeremy S. Dasen, PhD: control of motor neuron identity and connectivity
  • Gordon J. Fishell, PhD: development and integration of early-born SST-expressing interneurons
  • Robert C. Froemke, PhD: role of oxytocin in maternal behavior
  • Wenbiao Gan, PhD: experience-dependent plasticity of synaptic structure; in vivo studies of microglial functions in brain plasticity and pathology
  • Jorge A. Ghiso, PhD: characterization of beta amyloid peptides
  • Barbara Hempstead, PhD (Weill Cornell Medicine): molecular mechanisms of neurotrophin signaling
  • Konstantin Ichtchenko, PhD: Bacillus anthracis toxin post-translational modification characterization
  • Bryen Jordan, PhD (Albert Einstein College of Medicine): activity-dependent changes in postsynaptic density composition
  • Eric Kandel, MD (Columbia University): mechanisms of synaptic plasticity
  • Eric Klann, PhD (NYU’s Center for Neural Science): elF2-alpha phosphorylation in synaptic plasticity, memory, and brain disorders; translational control in synaptic plasticity and memory
  • Holger Knaut, PhD: molecular regulation of trigeminal sensory ganglia by SDF1 in zebrafish
  • Cary Lai, PhD (Indiana University): neuregulin-ERBB signaling
  • Francis S. Lee, PhD (Weill Cornell Medicine): functional analysis of variant BDNF (Val66Met)
  • Efrat Levy, PhD (NYU Langone/Nathan Kline Institute for Psychiatric Research): characterization of exosomes in Alzheimer’s disease
  • Paul M. Matthews, PhD (NYU Langone/Nathan Kline Institute for Psychiatric Research): role of apolipoprotein E (ApoE) alleles in Alzheimer’s disease susceptibility; mechanism of increased risk for Alzheimer’s disease in diabetes
  • Simon Geir Moller, PhD (St. John’s University): role of synuclein in Parkinson’s disease
  • Ralph A. Nixon, PhD (NYU Langone/Nathan Kline Institute for Psychiatric Research): neurofilament phosphorylation
  • Dimitris G. Placantonakis, MD, PhD: metabolomics and proteomics of gliomagenesis
  • Niels Ringstad, PhD: molecular mechanisms of functioning of sensory neurons in C. elegans
  • Bernardo Rudy, MD, PhD: molecular components of A-type K+ channels; development and function of 5HT3aR-expressing cortical GABAergic interneurons
  • Hyung Don Ryoo, PhD: retinal degeneration
  • Martin Sadowski, MD, PhD: physical interaction between ApoE and amyloid-beta
  • James L. Salzer, MD, PhD: phosphoproteomics of neuronal stimulation; mechanisms of node of Ranvier assembly
  • Einar M. Sigurdsson, PhD: epitope-specific targeting of tau aggregates
  • Nicholas Stavropoulos, PhD: mechanism of sleep in Drosophila
  • Richard Tsien, DPhil: modulation of neurotransmission by Ca++ and activity
  • Clarissa L. Waites, PhD (Columbia School of Medicine): molecular pathway for synaptic vesicle maintenance and degradation
  • Edward Ziff, PhD: AMPA receptor–associated proteins and synaptic plasticity; postsynaptic density changes in aging mice

Contact Us

The mass spectrometry core is located at NYU Langone’s Skirball Institute of Biomolecular Medicine at 540 First Avenue, fifth floor, lab 5-18. The facility is also known as the Seaver Mass Spectrometry Suite.

If you have questions about our facility or services, or if you would like to initiate a neuroscience-related mass spectrometry project, please contact Thomas A. Neubert, PhD, facility director, at thomas.neubert@nyulangone.org or 212-263-7265, or Jingjing Deng, lab manager, at jingjing.deng@nyulangone.org or 212-263-7266.

Steering Committee

Our steering committee guides the strategic and operational direction of the facility, mediates disputes, and sets and approves new policies concerning prioritization, access, and pricing.

Thomas A. Neubert, PhD
Committee Chair
Professor, Department of Cell Biology

Steven J. Burden, PhD
Professor, Departments of Cell Biology and Neuroscience and Physiology

Moses V. Chao, PhD
Professor, Departments of Cell Biology, Neuroscience and Physiology, and Psychiatry

Jorge A. Ghiso, PhD
Professor, Departments of Pathology and Psychiatry

Steven Gross, PhD
External Adviser
Professor, Department of Pharmacology and Director, Mass Spectrometry Core Facility Weill Cornell Medicine

Ralph A. Nixon, MD, PhD
Director, Silberstein Alzheimer’s Institute
Professor, Departments of Cell Biology and Psychiatry

Richard Tsien, DPhil
Director, Neuroscience Institute
Chair and The Druckenmiller Professor of Neuroscience, Department of Neuroscience and Physiology
Professor, Department of Neurology