Anna Nolan

Anna Nolan, MD

Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

inflammation, particulate matter, obstructive airways disease, World Trade Center, sepsis, environmental exposures , innate immunity , acute lung injury, chronic obstructive lung disease biomarkers, metabolomics, systems biology, Metabolic Syndrome, Dyslipidemia, Biomarkers, Aerodigestive Diseases

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.



Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

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Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

MD from SUNY Downstate Medical Center College of Medicine

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

Caraher, Erin J; Kwon, Sophia; Haider, Syed H; Crowley, George; Lee, Audrey; Ebrahim, Minah; Zhang, Liqun; Chen, Lung-Chi; Gordon, Terry; Liu, Mengling; Prezant, David J; Schmidt, Ann Marie; Nolan, Anna

PLoS one. 2017 Sep 19; 12(9):e0184331-e0184331e0184331

Haider, Syed H; Kwon, Sophia; Lam, Rachel; Lee, Audrey K; Caraher, Erin J; Crowley, George; Zhang, Liqun; Schwartz, Theresa M; Zeig-Owens, Rachel; Liu, Mengling; Prezant, David J; Nolan, Anna

Scientific reports. 2018 Feb 15; 8:3106-3106

Zeig-Owens, Rachel; Singh, Ankura; Aldrich, Thomas K; Hall, Charles B; Schwartz, Theresa; Webber, Mayris P; Cohen, Hillel W; Kelly, Kerry J; Nolan, Anna; Prezant, David J; Weiden, Michael D

Annals of the American Thoracic Society. 2018 Feb; 15(2):173-183

Hena, Kerry M; Yip, Jennifer; Jaber, Nadia; Goldfarb, David; Fullam, Kelly; Cleven, Krystal; Moir, William; Zeig-Owens, Rachel; Webber, Mayris P; Spevack, Daniel M; Judson, Marc A; Maier, Lisa; Krumerman, Andrew; Aizer, Anthony; Spivack, Simon D; Berman, Jessica; Aldrich, Thomas K; Prezant, David J; Christodoulou, Vasilios; Hena, Zachary; Plotycia, Steven M; Soghier, Israa; Gritz, David; Acuna, Dianne S; Weiden, Michael D; Nolan, Anna; Diaz, Keith; Ortiz, Viola; Kelly, Kerry

Chest. 2017 Oct 21; 153(1):114-123

Ahmed, N; Mukherjee, V; Rahman, F; Hossain, T; Hanif, A; Nolan, A

Chest. 2017 October; (CHEST):A609

Lee, Young Im; Smith, Robert L; Caraher, Erin J; Crowley, George; Haider, Syed Hissam; Kwon, Sophia; Nolan, Anna

Journal of clinical & translational science. 2017 Aug 17; 1(4):265-266

Quantitative Lung Morphology: Semiautomated Method Of Mean Chord Length Measurements [Meeting Abstract]

Crowley, G; Kwon, S; Haider, S; Caraher, EJ; Nolan, A; Nolan Lab

American journal of respiratory & critical care medicine. 2017; 195:?-?