Anna Nolan, MD

Assistant Professor, Department of Medicine

Assistant Professor, Department of Environmental Medicine

inflammation, particulate matter, obstructive airways disease, World Trade Center, sepsis, environmental exposures , innate immunity , acute lung injury, chronic obstructive lung disease biomarkers, metabolomics, systems biology

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

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Assistant Professor, Department of Medicine

Assistant Professor, Department of Environmental Medicine

Research Subject Safety Officer - GCRC

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

MD from State University of New York Downstate Medical Center

Validation Of Metabolic Syndrome Biomarkers Of Particulate Induced Lung Injury In World Trade Center Exposed Firefighters [Meeting Abstract]

Kwon, S; Caraher, EJ; Haider, SH; Schwartz, T; Zeig-Owens, R; Webber, MP; Prezant, D; Nolan, A

American journal of respiratory & critical care medicine. 2016; 193:?-?

Rage Contributes To Particulate-Induced Lung Function Loss And Hyperreactivity: Mitigating The Persistent Effects Of A Single Intense Particulate Exposure [Meeting Abstract]

Kwon, S; Haider, SH; Caraher, EJ; Crowley, G; Lee, AK; Ebrahim, M; Prezant, DJ; Schmidt, A; Nolan, A

American journal of respiratory & critical care medicine. 2016; 193:?-?

Kwon, Sophia; Crowley, George; Haider, Syed Hissam; Zhang, Liqun; Nolan, Anna

Journal of thoracic disease. 2016 Nov; 8(11):E1508-E1510

Kwon, Sophia; Caraher, Erin; Haider, Hissam; Crowley, George; Lee, Audrey; Prezant, David; Nolan, Anna

Chest. 2016; 149(4 Suppl):A408-A408

Aldrich, Thomas K; Weakley, Jessica; Dhar, Sean; Hall, Charles B; Crosse, Tesha; Banauch, Gisela I; Weiden, Michael D; Izbicki, Gabriel; Cohen, Hillel W; Gupta, Aanchal; King, Camille; Christodoulou, Vasilios; Webber, Mayris P; Zeig-Owens, Rachel; Moir, William; Nolan, Anna; Kelly, Kerry J; Prezant, David J

Chest. 2016 Dec; 150(6):1333-1340

Vossbrinck, Madeline; Zeig-Owens, Rachel; Hall, Charles B; Schwartz, Theresa; Moir, William; Webber, Mayris P; Cohen, Hillel W; Nolan, Anna; Weiden, Michael D; Christodoulou, Vasilios; Kelly, Kerry J; Aldrich, Thomas K; Prezant, David J

Occupational & environmental medicine. 2016 Nov 3; 74(3):200-203

Zeig-Owens, Rachel; Nolan, Anna; Putman, Barbara; Singh, Ankura; Prezant, David J; Weiden, Michael D

American journal of industrial medicine. 2016 Sep; 59(9):788-794

Kwon, Sophia; Putman, Barbara; Weakley, Jessica; Hall, Charles B; Zeig-Owens, Rachel; Schwartz, Theresa; Olivieri, Brianne; Singh, Ankura; Huie, Maryann; Morrison, Debra; Webber, Mayris P; Cohen, Hillel W; Kelly, Kerry J; Aldrich, Thomas K; Nolan, Anna; Prezant, David J; Shohet, Michael R; Weiden, Michael D

Annals of the American Thoracic Society. 2016 Aug; 13(8):1253-1261