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Anna Nolan

Anna Nolan, MD

Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

Keywords
Lung Disease, World Trade Center, Biomarkers, Sepsis, Multiomics, Metabolic Syndrome, September 11th Terrorist Attacks, Systems Biology
Summary

We have been studying predictors of lung function loss in firefighters who never smoked from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre-9/11/01 (9/11) clinical/spirometric data and continues to have serial post-9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within six months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid-induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of particulate matter exposure.

Phone

212-263-7283

Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

Lab Website
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Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

MD from SUNY Downstate Medical Center College of Medicine

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

Jasra, Sakshi; Giricz, Orsi; Zeig-Owens, Rachel; Goldfarb, David; Barreto-Galvez, Angelica; Pradhan, Kith; Chen, Jiahao; Choudhary, Gaurav S; Aluri, Srinivas Bhagat, Tushar D; Shastri, Aditi; Thiruthuvanathan, Victor; Goto, Hiroki; Gerhardt, Jeannine; Gordon, Shanisha; Veerappan, Arul; Haider, Syed Hissam; Bartenstein, Matthias; Nwankwo, George; Landgren, Ola; Weiden, Michael; Fletcher, Frederick; Greenberger, Lee; Ebert, Benjamin L; Steidl, Ulrich G; Will, Britta; Nolan, Anna; Prezant, David; Madireddy, Advaitha; Verma, Amit

[S.l.] : ASH Annual Meeting, 2019. 2019; https://ash.confex.com/ash/2019/webprogram/Paper129276.html (4259182)

Crowley, George; Kwon, Sophia; Caraher, Erin J; Haider, Syed Hissam; Lam, Rachel; Batra, Prag; Melles, Daniel; Liu, Mengling; Nolan, Anna

BMC pulmonary medicine. 2019 Nov 09; 19(1):206

Citron, Julia; Willcocks, Emma; Crowley, George; Kwon, Sophia; Nolan, Anna

International journal of environmental research & public health. 2019 11 07; 16(22):

de la Hoz, Rafael E; Jeon, Yunho; Reeves, Anthony P; San José Estépar, Raúl; Liu, Xiaoyu; Doucette, John T; Celedón, Juan C; Nolan, Anna

Clinical respiratory journal. 2019 Oct; 13(10):614-623

Crowley, George; Kwon, Sophia; Ostrofsky, Dean F; Clementi, Emily A; Haider, Syed Hissam; Caraher, Erin J; Lam, Rachel; St-Jules, David E; Liu, Mengling; Prezant, David J; Nolan, Anna

Scientific reports. 2019 Sep 03; 9(1):11939

Kwon, Sophia; Crowley, George; Caraher, Erin J; Haider, Syed Hissam; Lam, Rachel; Veerappan, Arul; Yang, Lei; Liu, Mengling; Zeig-Owens, Rachel; Schwartz, Theresa; Prezant, David J; Nolan, Anna

Chest. 2019 Sep; 156(3):486-496

Kwon, Sophia; Crowley, George; Mikhail, Mena; Lam, Rachel; Clementi, Emily; Zeig-Owens, Rachel; Schwartz, Theresa M; Liu, Mengling; Prezant, David J; Nolan, Anna

International journal of environmental research & public health. 2019 04 26; 16(9):

Haider, Syed H; Oskuei, Assad; Crowley, George; Kwon, Sophia; Lam, Rachel; Riggs, Jessica; Mikhail, Mena; Talusan, Angela; Veerappan, Arul; Kim, James S; Caraher, Erin J; Nolan, Anna

European respiratory review. 2019 Mar 31; 28(151):