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Anna Nolan

Anna Nolan, MD

Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

Keywords
Lung Disease, World Trade Center, Biomarkers, Sepsis, Multiomics
Summary

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

Phone

212-263-7283

Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

MD from SUNY Downstate Medical Center College of Medicine

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

Kwon, S; Clementi, E; Crowley, G; Schwartz, T; Zeig-Owens, R; Liu, M; Prezant, D; Nolan, A

Chest. 2019 April; Conference:(CHEST):142A

Riggs, J; Lam, R; Kwon, S; Crowley, G; Oskuei, A; Liu, M; St , Jules D; Prezant, D; Sevick, M A; Nolan, A

Chest. 2019 April; Conference:(CHEST):227A

Haider, Syed H; Oskuei, Assad; Crowley, George; Kwon, Sophia; Lam, Rachel; Riggs, Jessica; Mikhail, Mena; Talusan, Angela; Veerappan, Arul; Kim, James S; Caraher, Erin J; Nolan, Anna

European respiratory review. 2019 Mar 31; 28(151):

Kwon, Sophia; Crowley, George; Caraher, Erin J; Haider, Syed Hissam; Lam, Rachel; Veerappan, Arul; Yang, Lei; Liu, Mengling; Zeig-Owens, Rachel; Schwartz, Theresa; Prezant, David J; Nolan, Anna

Chest. 2019 Mar 02;

Clementi, Emily A; Talusan, Angela; Vaidyanathan, Sandhya; Veerappan, Arul; Mikhail, Mena; Ostrofsky, Dean; Crowley, George; Kim, James S; Kwon, Sophia; Nolan, Anna

Toxics. 2019 Jan 30; 7(1):

Mikhail, Mena; Crowley, George; Haider, Syed Hissam; Veerappan, Arul; Lam, Rachel; Talusan, Angela; Clementi, Emily; Ostrofsky, Dean; Kwon, Sophia; Nolan, Anna

EMJ. Gastroenterology. 2018 Dec; 7(1):103-112

Singh, Ankura; Liu, Charles; Putman, Barbara; Zeig-Owens, Rachel; Hall, Charles B; Schwartz, Theresa; Webber, Mayris P; Cohen, Hillel W; Berger, Kenneth I; Nolan, Anna; Prezant, David J; Weiden, Michael D

Chest. 2018 Dec; 154(6):1301-1310

Beattie, Jason; Parajuli, Sunita; Sanger, Matthew; Lee, Gregory; Pleninger, Perrin; Crowley, George; Kwon, Sophia; Murthy, Vivek; Manko, Jeffrey A; Caplan, Arthur; Dufort, Elizabeth; Pastula, Daniel M; Nolan, Anna

Infectious diseases in clinical practice. 2018 Nov; 26(6):e80-e84