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Anna Nolan

Anna Nolan, MD

Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

Keywords
Lung Disease, World Trade Center, Biomarkers, Sepsis, Multiomics
Summary

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

Phone

212-263-7283

Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

MD from SUNY Downstate Medical Center College of Medicine

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

Singh, Ankura; Liu, Charles; Putman, Barbara; Zeig-Owens, Rachel; Hall, Charles B; Schwartz, Theresa; Webber, Mayris P; Cohen, Hillel W; Berger, Kenneth I; Nolan, Anna; Prezant, David J; Weiden, Michael D

Chest. 2018 Dec 21; 154(6):1301-1310

Zika Virus-Associated Guillain-Barre Syndrome in a Returning US Traveler

Beattie, J; Parajuli, S; Sanger, M; Lee, G; Pleninger, P; Crowley, G; Kwon, S; Murthy, V; Manko, J A; Caplan, A; Dufort, E; Pastula, D M; Nolan, A

Infectious diseases in clinical practice. 2018 Nov 01; 26(6):e80-e84

Crowley, George; Kwon, Sophia; Haider, Syed Hissam; Caraher, Erin J; Lam, Rachel; St-Jules, David E; Liu, Mengling; Prezant, David J; Nolan, Anna

BMJ open respiratory research. 2018 Sep 03; 5(1):e000274-e000274

Haider, Syed H; Kwon, Sophia; Lam, Rachel; Lee, Audrey K; Caraher, Erin J; Crowley, George; Zhang, Liqun; Schwartz, Theresa M; Zeig-Owens, Rachel; Liu, Mengling; Prezant, David J; Nolan, Anna

Scientific reports. 2018 Feb 15; 8(1):3106-3106

Zeig-Owens, Rachel; Singh, Ankura; Aldrich, Thomas K; Hall, Charles B; Schwartz, Theresa; Webber, Mayris P; Cohen, Hillel W; Kelly, Kerry J; Nolan, Anna; Prezant, David J; Weiden, Michael D

Annals of the American Thoracic Society. 2018 02; 15(2):173-183

Hena, Kerry M; Yip, Jennifer; Jaber, Nadia; Goldfarb, David; Fullam, Kelly; Cleven, Krystal; Moir, William; Zeig-Owens, Rachel; Webber, Mayris P; Spevack, Daniel M; Judson, Marc A; Maier, Lisa; Krumerman, Andrew; Aizer, Anthony; Spivack, Simon D; Berman, Jessica; Aldrich, Thomas K; Prezant, David J; Christodoulou, Vasilios; Hena, Zachary; Plotycia, Steven M; Soghier, Israa; Gritz, David; Acuna, Dianne S; Weiden, Michael D; Nolan, Anna; Diaz, Keith; Ortiz, Viola; Kelly, Kerry

Chest. 2018 Jan 26; 153(1):114-123

Lipids as Modifiable Risk Factors of Environmental Lung Disease: A Systematic Review of the Good, the Bad and the Misunderstood [Meeting Abstract]

Caraher, E.; Crowley, G.; Haider, S.; Lam, R.; Kwon, S.; Nolan, A.

American journal of respiratory & critical care medicine. 2018; 197:?-?