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Anna Nolan

Anna Nolan, MD

Professor, Department of Medicine

Keywords
COVID-19, BIOMARKERS, Machine Learning, Lung Inflammation, WTC Attacks, Lung Disease, Prediction Models, Metabolic Syndrome, Cardiovascular Disease, Aerodigestive Disease
Summary

We have been studying predictors of lung function loss in firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre-9/11/01 (9/11) clinical/spirometric data and continues to have serial post-9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within six months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid-induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of particulate matter exposure.

Phone

212-263-7283

Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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MD from SUNY-Downstate

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

de la Hoz, Rafael E; Shapiro, Moshe; Nolan, Anna; Sood, Akshay; Lucchini, Roberto G; Cone, James E; Celedón, Juan C

Lung. 2023 Aug; 201(4):325-334

Durmus, Nedim; Chen, Wen-Chi; Park, Sung-Hyun; Marsh, Leigh M; Kwon, Sophia; Nolan, Anna; Grunig, Gabriele

International journal of molecular sciences. 2023 Jul 25; 24(15):

Durmus, Nedim; Chen, Wen Chi; Park, Sung-Hyun; Marsh, Leigh; Kwon, Sophia; Nolan, Anna; Grunig, Gabriele

Preprints.org. 2023 June 07;

de la Hoz, Rafael E; Shapiro, Moshe; Nolan, Anna; Sood, Akshay; Lucchini, Roberto G; Cone, James E; Celedon, Juan C

SSRN. 2023 Feb 27;

Podury, Sanjiti; Kwon, Sophia; Javed, Urooj; Farooqi, Muhammad S; Li, Yiwei; Liu, Mengling; Grunig, Gabriele; Nolan, Anna

Life (Basel, Switzerland). 2023 Feb 15; 13(2):

Farooqi, Muhammad S; Podury, Sanjiti; Crowley, George; Javed, Urooj; Li, Yiwei; Liu, Mengling; Kwon, Sophia; Grunig, Gabriele; Khan, Abraham R; Francois, Fritz; Nolan, Anna

Gastro hep advances. 2023 Jan 20;

de la Hoz, Rafael E.; Shapiro, Moshe; Nolan, Anna; Sood, Akshay; Lucchini, Roberto G.; Cone, James E.; Celedón, Juan C.

Lung. 2023 Jan 01; ?-?

Farooqi, Muhammad S; Podury, Sanjiti; Crowley, George; Kwon, Sophia; Khan, Abraham R; Francois, Fritz; Nolan, Anna

medRxiv : the preprint server for health sciences. 2022 Jun 21;