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Anna Nolan

Anna Nolan, MD

Associate Professor, Department of Medicine

Associate Professor, Department of Environmental Medicine

Keywords
Lung Disease, World Trade Center, Biomarkers, Sepsis, Multiomics, Metabolic Syndrome, September 11th Terrorist Attacks, Systems Biology
Summary

We have been studying predictors of lung function loss in firefighters who never smoked from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre-9/11/01 (9/11) clinical/spirometric data and continues to have serial post-9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within six months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid-induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of particulate matter exposure.

Phone

212-263-7283

Academic office

462 1st Avenue, New Bellevue

16, S 16(Office)/ N 20 (Lab)

New York, NY 10016

Lab Website
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MD from SUNY Downstate Medical Center College of Medicine

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

New York University, Masters in Clinical Investigation

Kwon, Sophia; Riggs, Jessica; Crowley, George; Lam, Rachel; Young, Isabel R; Nayar, Christine; Sunseri, Maria; Mikhail, Mena; Ostrofsky, Dean; Veerappan, Arul; Zeig-Owens, Rachel; Schwartz, Theresa; Colbeth, Hilary; Liu, Mengling; Pompeii, Mary Lou; St-Jules, David; Prezant, David J; Sevick, Mary Ann; Nolan, Anna

International journal of environmental research & public health. 2020 Sep 09; 17(18):

Haider, Syed Hissam; Veerappan, Arul; Crowley, George; Ostrofsky, Dean; Mikhail, Mena; Lam, Rachel; Wang, Yuyan; Sunseri, Maria; Kwon, Sophia; Prezant, David J; Liu, Mengling; Schmidt, Ann Marie; Nolan, Anna

American journal of respiratory cell & molecular biology. 2020 Aug; 63(2):219-233

de la Hoz, Rafael E; Shapiro, Moshe; Nolan, Anna; Celedón, Juan C; Szeinuk, Jaime; Lucchini, Roberto G

Respiratory medicine. 2020 Aug - Sep; 170:106058

Lam, Rachel; Haider, Syed H; Crowley, George; Caraher, Erin J; Ostrofsky, Dean F; Talusan, Angela; Kwon, Sophia; Prezant, David J; Wang, Yuyan; Liu, Mengling; Nolan, Anna

International journal of environmental research & public health. 2020 06 17; 17(12):

Sengupta, Vikram; Sengupta, Sascha; Lazo, Angel; Woods, Peter; Nolan, Anna; Bremer, Nicholas

Stem cells & development. 2020 Jun 15; 29(12):747-754

Veerappan, Arul; Oskuei, Assad; Crowley, George; Mikhail, Mena; Ostrofsky, Dean; Gironda, Zakia; Vaidyanathan, Sandhya; Wadghiri, Youssef Zaim; Liu, Mengling; Kwon, Sophia; Nolan, Anna

Scientific reports. 2020 Feb 21; 10(1):3130

Jasra, Sakshi; Giricz, Orsi; Zeig-Owens, Rachel; Goldfarb, David; Barreto-Galvez, Angelica; Pradhan, Kith; Chen, Jiahao; Choudhary, Gaurav S; Aluri, Srinivas Bhagat, Tushar D; Shastri, Aditi; Thiruthuvanathan, Victor; Goto, Hiroki; Gerhardt, Jeannine; Gordon, Shanisha; Veerappan, Arul; Haider, Syed Hissam; Bartenstein, Matthias; Nwankwo, George; Landgren, Ola; Weiden, Michael; Fletcher, Frederick; Greenberger, Lee; Ebert, Benjamin L; Steidl, Ulrich G; Will, Britta; Nolan, Anna; Prezant, David; Madireddy, Advaitha; Verma, Amit

[S.l.] : ASH Annual Meeting, 2019. 2019; https://ash.confex.com/ash/2019/webprogram/Paper129276.html (4259182)

Crowley, George; Kwon, Sophia; Caraher, Erin J; Haider, Syed Hissam; Lam, Rachel; Batra, Prag; Melles, Daniel; Liu, Mengling; Nolan, Anna

BMC pulmonary medicine. 2019 Nov 09; 19(1):206