Anna Nolan

Assistant Professor, Department of Medicine

Assistant Professor, Department of Environmental Medicine

Keywords
inflammation, particulate matter, obstructive airways disease, World Trade Center, sepsis, environmental exposures , innate immunity , acute lung injury, chronic obstructive lung disease biomarkers, metabolomics, systems biology
Summary

We have been studying predictors of lung function loss in never smoking firefighters from the World Trade Center (WTC) exposed Fire Department of New York (FDNY) cohort. This well phenotyped group has pre 9/11/01 (9/11) clinical/spirometric data and continues to have serial post 9/11 assessments. Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction. The mechanism of lipid induced pulmonary inflammation is poorly understood. Metabolites of low-density lipoprotein (LDL) cause vascular injury. In preliminary data we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later. Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

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Assistant Professor, Department of Medicine

Assistant Professor, Department of Environmental Medicine

Research Subject Safety Officer - GCRC

Fellowship, New York University School of Medicine, Pulmonary and Critical Care

Residency, St. Lukes-Roosevelt Hospital Center, Medicine

Validation Of Metabolic Syndrome Biomarkers Of Particulate Induced Lung Injury In World Trade Center Exposed Firefighters [Meeting Abstract]

Kwon, S; Caraher, EJ; Haider, SH; Schwartz, T; Zeig-Owens, R; Webber, MP; Prezant, D; Nolan, A

American journal of respiratory & critical care medicine. 2016; 193:?-?

Rage Contributes To Particulate-Induced Lung Function Loss And Hyperreactivity: Mitigating The Persistent Effects Of A Single Intense Particulate Exposure [Meeting Abstract]

Kwon, S; Haider, SH; Caraher, EJ; Crowley, G; Lee, AK; Ebrahim, M; Prezant, DJ; Schmidt, A; Nolan, A

American journal of respiratory & critical care medicine. 2016; 193:?-?

Kwon, Sophia; Crowley, George; Haider, Syed Hissam; Zhang, Liqun; Nolan, Anna

Journal of thoracic disease. 2016 Nov; 8(11):E1508-E1510

Kwon, Sophia; Caraher, Erin; Haider, Hissam; Crowley, George; Lee, Audrey; Prezant, David; Nolan, Anna

Chest. 2016; 149(4 Suppl):A408-A408

Quantitative Lung Morphology: Semiautomated Method Of Mean Chord Length Measurements [Meeting Abstract]

Crowley, G; Kwon, S; Haider, S; Caraher, EJ; Nolan, A; Nolan Lab

American journal of respiratory & critical care medicine. 2017; 195:?-?

Critical Care In The Resource-Limited Setting: Implications Of A Needs-Assessment In A Public Hospital In Dhaka, Bangladesh [Meeting Abstract]

Ahmed, N; Nolan, A; Mukherjee, V; Rouf, A; Hanif, A

American journal of respiratory & critical care medicine. 2017; 195:?-?

Zika Virus-Associated Guillain-Barre Syndrome In A Returning United States Traveler [Meeting Abstract]

Beattie, J; Parajuli, S; Sanger, M; Lee, G; Pleninger, P; Crowley, G; Kwon, S; Murthy, V; Manko, J; Caplan, A; Dufort, E; Staples, JE; Pastula, D; Nolan, A

American journal of respiratory & critical care medicine. 2017; 195:?-?

Metabolic Fingerprints Of Protection From World Trade Center-Lung Injury: A Pilot Study [Meeting Abstract]

Crowley, G; Kwon, S; Haider, S; Zhang, L; Lam, R; Zeig-Owens, R; Webber, MP; Schwartz, T; Prezant, D; Liu, M; Nolan, A; Nolan Lab

American journal of respiratory & critical care medicine. 2017; 195:?-?