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Ashira Blazer

Ashira Blazer, MD

Assistant Professor, Department of Medicine

Keywords
lupus, African American, APOL1
Summary

Considered a prototypic autoimmune disorder, systemic lupus erythematosus (SLE) represents a phenotypically heterogeneous syndrome with multiple genetic, environmental, and immunologic contributions to pathogenesis. With increased prevalence of renal disease, cardiovascular disease, and hypertension, lupus patients of African lineage often experience higher severity of disease and accelerated damage accrual. Studies have shown that African American (AA) women develop subclinical cardiovascular disease (CVD) at earlier ages and with higher frequency. Moreover, AA SLE patients have a higher incidence of hypertension, a variable associated with accelerated damage accrual. Genetic factors contributing to this trend are poorly recognized.  Two cytokine-responsive genetic variants of apolipoprotein L1 (APOL1) have been linked to both atherosclerosis and renal disease in homozygous carriers. In SLE, chronic inflammation may be an important amplifying factor increasing the consequence of carrying one or more of these genetic polymorphisms. In conjunction with my primary mentors, I have generated data demonstrating increased risk of hypertension, cardiovascular disease, and end stage renal disease in SLE patients carrying one or more risk variant copies.  As well, upon treatment with inflammatory cytokines, interferon alpha and gamma, we have observed decreased viability and increased cell death in APOL1 risk variant-carrying primary endothelial cell cultures. This cytokines are central to SLE pathogenesis and may potentiate disease in patients carrying these variants. 

Academic office

301 East 17th Street

Suite 1410

New York, NY 10029

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Assistant Professor, Department of Medicine

MD from Baylor College of Medicine

Fellowship, New York University Langone School of Medicine, Rheumatology

Residency, Vanderbilt University Medical Center, Internal Medicine

Apolipoprotein l1 risk variants associate with poor renal outcomes, damage accrual, and death: A prospective Ghanaian SLE cohort [Meeting Abstract]

Blazer, A; Dey, I D; Reynolds, M; Ankrah, F; Schmidt, N; Clancy, R M; Buyon, J P

Arthritis & rheumatology. 2018 September; Conference:(American):2174-2175

Apolipoprotein l1 risk variants, renal histopathology, and prognosis in African American sle nephritis patients: A cohort study [Meeting Abstract]

Blazer, A; Wu, M; Schmidt, N; Engelbrecht, A; Liang, F -X; Clancy, R M; Buyon, J P; Belmont, H M

Arthritis & rheumatology. 2018 September; Conference:(American):115

Apolipoprotein L1 Risk Variants Associate with Hypertension and Nephritis Progression Despite Lower dsDNA Titers in Ghanaian Systemic Lupus Erythematous Patients [Meeting Abstract]

Blazer, Ashira; Dey, Ida Dzifa; Rasmussen, Sara; Clancy, Robert M; Buyon, Jill P

Arthritis & rheumatology. 2017 OCT; 69:?-?

Interferon-Induced APOL1 over-Expression Causes Autophagic Dysfunction and Mitochondrial Stress in Risk Variant-Carrying Endothelial Cells [Meeting Abstract]

Blazer, Ashira; Rasmussen, Sara; Markham, Androo; Mehta-Lee, Shilpi; Buyon, Jill P; Clancy, Robert M

Arthritis & rheumatology. 2017 OCT; 69:?-?

Blazer, Ashira D; Clancy, Robert M

Current rheumatology reports. 2017 Mar; 19(3):13

Blazer, Ashira; Wang, Binhuan; Simpson, Danny; Kirchhoff, Tomas; Heffron, Sean; Clancy, Robert M; Heguy, Adriana; Ray, Karina; Snuderl, Matija; Buyon, Jill P

PLoS one. 2017 Aug; 12(8):e0182483

Apolipoprotein L1 Risk Variants Associate with Prevalent Cardiovascular Disease in African American Systemic Lupus Erythematous Patients [Meeting Abstract]

Blazer, Ashira; Clancy, Robert M.; Belmont, H. Michael; Izmirly, Peter M.; Markham, Androo; Buyon, Jill P.

Arthritis & rheumatology. 2016 OCT; 68:?-?

Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE [Meeting Abstract]

Blazer, Ashira; Markham, Andrew; Rasmussen, Sara; Buyon, Jill P; Belmont, HMichael; Mehta-Lee, Shilpi; Nwaukoni, Janet; Izmirly, Peter M; Clancy, Robert

Arthritis & rheumatology. 2015 Oct; 67:?-?