Chuanshu Huang

Chuanshu Huang

Professor, Department of Environmental Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Urology

signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention, reactive oxygen species (ROS) involved in cellular signaling and cancer development, molecular mechanism of anti-cancer nutrients, environment and carcinogenesis, cancer

Exposure of cells to environmental carcinogens results in activation of transcription factors and regulation of their target genes through signal transduction pathways, which have been characterized as tumor promotion and progression stages of carcinogenesis.  Elucidation of signal transduction pathways will, therefore, not only define the central scientific hunt in cancer biology and open an unprecedented window into the nature of cancer, but also will be necessary for cancer prevention and therapy as well.  As a result, my research addresses fundamental questions concerning the responses of mammalian cells to environmental carcinogens at the levels of protein kinases, transcription factors and their target genes, as well as protein modification both in vitro and in vivo. My major research findings include: 1), identifying novel signaling pathways triggering cellular apoptosis in cell responses to environmental stress, such as, we identify a novel signaling pathway of p85/NFAT3/TNF for mediating cell apoptosis upon UV radiation. Our most recently studies also characterize a novel pro-apoptotic pathway of IKK/NF-κB p50/GADD45/JNK in cellular response to arsenite; 2), demonstrating role of the transcription factor NFAT in environmental carcinogenic response; 3), elucidating molecular mechanisms of carcinogenic effect of arsenite exposure; 4), initiating finding of crucial role of PI-3K/Akt pathway in carcinogenic responses and as a target for chemoprevention; 5), identifying a novel function of XIAP acting as a modulator of RhoGDI sumoylation, by which XIAP mediates cancer cell motility and metastasis.



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Tuxedo, NY 10987

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Professor, Department of Environmental Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Urology

Environmental Medicine Deputy Director

Jin, Honglei; Xie, Qipeng; Guo, Xirui; Xu, Jiheng; Wang, Annette; Li, Jingxia; Zhu, Junlan; Wu, Xue-Ru; Huang, Haishan; Huang, Chuanshu

Journal of biological chemistry. 2017 Aug 9; ?-?

Zhu, Junlan; Li, Yang; Chen, Caiyi; Ma, Jiugao; Sun, Wenrui; Tian, Zhongxian; Li, Jingxia; Xu, Jiheng; Liu, Claire S; Zhang, Dongyun; Huang, Chuanshu; Huang, Haishan

Neoplasia. 2017 Jul 31; 19(9):672-683

Zhu, Junlan; Li, Yang; Tian, Zhongxian; Hua, Xiaohui; Gu, Jiayan; Li, Jingxia; Liu, Claire; Jin, Honglei; Wang, Yulei; Jiang, Guosong; Huang, Haishan; Huang, Chuanshu

Molecular therapy. Nucleic acids. 2017 Jun 16; 7:299-313

Jiang, Guosong; Huang, Chao; Li, Jingxia; Huang, Haishan; Jin, Honglei; Zhu, Junlan; Wu, Xue-Ru; Huang, Chuanshu

Molecular cancer therapeutics. 2017 Feb 21; 16(5):924-935

Huang, Chao; Zeng, Xingruo; Jiang, Guosong; Liao, Xin; Liu, Claire; Li, Jingxia; Jin, Honglei; Zhu, Junlan; Sun, Hong; Wu, Xue-Ru; Huang, Chuanshu

Journal of hematology & oncology. 2017 Jan 05; 10(1):6-6

Zhang, Ruowen; Che, Xun; Zhang, Jingjie; Li, Yang; Li, Jingxia; Deng, Xu; Zhu, Junlan; Jin, Honglei; Zhao, Qinshi; Huang, Chuanshu

Oncotarget. 2016 Oct 11; 7(41):66689-66699

Huang, Haishan; Zhu, Junlan; Li, Yang; Zhang, Liping; Gu, Jiayan; Xie, Qipeng; Jin, Honglei; Che, Xun; Li, Jingxia; Huang, Chao; Chen, Lung-Chi; Lyu, Jianxin; Gao, Jimin; Huang, Chuanshu

Autophagy. 2016 Oct 02; 12(10):1687-1703

Jin, Honglei; Xu, Jiheng; Guo, Xirui; Huang, Haishan; Li, Jingxia; Peng, Minggang; Zhu, Junlan; Tian, Zhongxian; Wu, Xue-Ru; Tang, Moon-Shong; Huang, Chuanshu

Oncotarget. 2016 Aug 30; 7(35):56540-56557