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Chuanshu Huang

Chuanshu Huang

Professor, Department of Environmental Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Urology

Keywords
signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention, reactive oxygen species (ROS) involved in cellular signaling and cancer development, molecular mechanism of anti-cancer nutrients, environment and carcinogenesis, cancer
Summary

Exposure of cells to environmental carcinogens results in activation of transcription factors and regulation of their target genes through signal transduction pathways, which have been characterized as tumor promotion and progression stages of carcinogenesis.  Elucidation of signal transduction pathways will, therefore, not only define the central scientific hunt in cancer biology and open an unprecedented window into the nature of cancer, but also will be necessary for cancer prevention and therapy as well.  As a result, my research addresses fundamental questions concerning the responses of mammalian cells to environmental carcinogens at the levels of protein kinases, transcription factors and their target genes, as well as protein modification both in vitro and in vivo. My major research findings include: 1), identifying novel signaling pathways triggering cellular apoptosis in cell responses to environmental stress, such as, we identify a novel signaling pathway of p85/NFAT3/TNF for mediating cell apoptosis upon UV radiation. Our most recently studies also characterize a novel pro-apoptotic pathway of IKK/NF-κB p50/GADD45/JNK in cellular response to arsenite; 2), demonstrating role of the transcription factor NFAT in environmental carcinogenic response; 3), elucidating molecular mechanisms of carcinogenic effect of arsenite exposure; 4), initiating finding of crucial role of PI-3K/Akt pathway in carcinogenic responses and as a target for chemoprevention; 5), identifying a novel function of XIAP acting as a modulator of RhoGDI sumoylation, by which XIAP mediates cancer cell motility and metastasis.

Phone

845-731-3519

Academic office

57 Old Forge Rd.

Ground Floor

Tuxedo, NY 10987

Lab Website
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Professor, Department of Environmental Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Urology

Environmental Medicine Deputy Director

Jin, Honglei; Xue, Lei; Mo, Lan; Zhang, Dongyun; Guo, Xirui; Xu, Jiheng; Li, Jingxia; Peng, Minggang; Zhao, Xuewei; Zhong, Minghao; Xu, Dazhong; Wu, Xue-Ru; Huang, Haishan; Huang, Chuanshu

Cell adhesion & migration. 2019 Dec; 13(1):236-248

Wang, Jingjing; Zhang, Ning; Peng, Minggang; Hua, Xiaohui; Huang, Chao; Tian, Zhongxian; Xie, Qipeng; Zhu, Junlan; Li, Jingxia; Huang, Haishan; Huang, Chuanshu

Neoplasia. 2019 Aug 08; 21(9):908-920

Yan, Huiying; Ren, Shuwei; Lin, Qi; Yu, Yuan; Chen, Caiyi; Hua, Xiaohui; Jin, Honglei; Lu, Yongyong; Zhang, Huxiang; Xie, Qipeng; Huang, Chuanshu; Huang, Haishan

FASEB journal. 2019 Aug 02; fj201900499RR

Tian, Zhongxian; Luo, Yisi; Zhu, Junlan; Hua, Xiaohui; Xu, Jiheng; Huang, Chao; Jin, Honglei; Huang, Haishan; Huang, Chuanshu

Biochimica & biophysica acta. Gene regulatory mechanisms. 2019 Aug; 1862(8):822-833

Hua, Xiaohui; Huang, Maowen; Deng, Xu; Xu, Jiheng; Luo, Yisi; Xie, Qipeng; Xu, Jiawei; Tian, Zhongxian; Li, Jingxia; Zhu, Junlan; Huang, Chao; Zhao, Qin-Shi; Huang, Haishan; Huang, Chuanshu

Cell death & differentiation. 2019 Jun 26;

Luo, Yisi; Tian, Zhongxian; Hua, Xiaohui; Huang, Maowen; Xu, Jiheng; Li, Jingxia; Huang, Haishan; Cohen, Mitchell; Huang, Chuanshu

Cellular & molecular life sciences: CMLS. 2019 Jun 20;

Xie, Qipeng; Chen, Caiyi; Li, Haiying; Xu, Jiheng; Wu, Lei; Yu, Yuan; Ren, Shuwei; Li, Hongyan; Hua, Xiaohui; Yan, Huiying; Rao, Dapang; Zhang, Huxiang; Jin, Honglei; Huang, Haishan; Huang, Chuanshu

Molecular therapy. 2019 May 08; 27(5):1028-1038

Zhu, Junlan; Tian, Zhongxian; Li, Yang; Hua, Xiaohui; Zhang, Dongyun; Li, Jingxia; Jin, Honglei; Xu, Jiheng; Chen, Wei; Niu, Beifang; Wu, Xue-Ru; Comincini, Sergio; Huang, Haishan; Huang, Chuanshu

Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2019 Apr 17; 6(8):1801927