Exposure of cells to environmental carcinogens results in activation of transcription factors and regulation of their target genes through signal transduction pathways, which have been characterized as tumor promotion and progression stages of carcinogenesis. Elucidation of signal transduction pathways will, therefore, not only define the central scientific hunt in cancer biology and open an unprecedented window into the nature of cancer, but also will be necessary for cancer prevention and therapy as well. As a result, my research addresses fundamental questions concerning the responses of mammalian cells to environmental carcinogens at the levels of protein kinases, transcription factors and their target genes, as well as protein modification both in vitro and in vivo. My major research findings include: 1), identifying novel signaling pathways triggering cellular apoptosis in cell responses to environmental stress, such as, we identify a novel signaling pathway of p85/NFAT3/TNF for mediating cell apoptosis upon UV radiation. Our most recently studies also characterize a novel pro-apoptotic pathway of IKK/NF-κB p50/GADD45/JNK in cellular response to arsenite; 2), demonstrating role of the transcription factor NFAT in environmental carcinogenic response; 3), elucidating molecular mechanisms of carcinogenic effect of arsenite exposure; 4), initiating finding of crucial role of PI-3K/Akt pathway in carcinogenic responses and as a target for chemoprevention; 5), identifying a novel function of XIAP acting as a modulator of RhoGDI sumoylation, by which XIAP mediates cancer cell motility and metastasis.
Professor, Department of Environmental Medicine
Professor, Department of Biochemistry and Molecular Pharmacology
Professor, Department of Urology
Environmental Medicine Deputy Director
Journal of biological chemistry. 2017 Aug 9; ?-?
Neoplasia. 2017 Jul 31; 19(9):672-683
Molecular therapy. Nucleic acids. 2017 Jun 16; 7:299-313
Molecular cancer therapeutics. 2017 Feb 21; 16(5):924-935
Journal of hematology & oncology. 2017 Jan 05; 10(1):6-6
Oncotarget. 2016 Oct 11; 7(41):66689-66699
Autophagy. 2016 Oct 02; 12(10):1687-1703
Oncotarget. 2016 Aug 30; 7(35):56540-56557