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Dirk Trauner, PhD

Neuroscience Institute

Adjunct Professor, Department of Neuroscience and Physiology

photopharmacology, optogenetics, channels, transporters, GPCRs, cytoskeleton, molecular neuroscience, electrophysiology

Neuroscience is one of the most exciting fields of research and synthetic chemistry can contribute much to its further development. Our current focus lies on the functional manipulation of ion channels, GPCRs, and transporters with synthetic photoswitches.

The artificial photoreceptors so obtained can be inserted into neurons and other cell types and can be used to control various biological pathways with light (Photopharmacology). One of our major biological goals is the restoration of vision in the blind using synthetic photoswitches.
The reach of photopharmacology, however, goes well beyond applications in neuroscience and sensory physiology. It is already clear that this approach is very useful for controlling the highly dynamic systems that underlie cell motility, cell division and (unwanted) proliferation. As such, photopharmacology provides powerful tools for cell biology and could open a new direction in precision medicine.

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Adjunct Professor, Department of Neuroscience and Physiology

PhD from University of Vienna

Donthamsetti, Prashant C; Broichhagen, Johannes; Vyklicky, Vojtech; Stanley, Cherise; Fu, Zhu; Visel, Meike; Levitz, Joshua L; Javitch, Jonathan A; Trauner, Dirk; Isacoff, Ehud Y

Journal of the American Chemical Society. 2019 Jul 24; 141(29):11522-11530

Kol, Matthijs; Williams, Ben; Toombs-Ruane, Henry; Franquelim, Henri G; Korneev, Sergei; Schroeer, Christian; Schwille, Petra; Trauner, Dirk; Holthuis, Joost Cm; Frank, James A

eLife. 2019 Feb 05; 8:

Rizzo, Antonio; Mayer, Robert J; Trauner, Dirk

Journal of organic chemistry. 2019 Feb 01; 84(3):1162-1175

Leippe, Philipp; Winter, Nils; Sumser, Martin P; Trauner, Dirk

ACS chemical neuroscience. 2018 Dec 19; 9(12):2886-2891

Frank, James A; Broichhagen, Johannes; Yushchenko, Dmytro A; Trauner, Dirk; Schultz, Carsten; Hodson, David J

Nature reviews. Endocrinology. 2018 Dec; 14(12):721-737

Reyes, Julius R; Winter, Nils; Spessert, Lukas; Trauner, Dirk

Angewandte chemie. International edition in English. 2018 Nov 19; 57(47):15587-15591

Hüll, Katharina; Morstein, Johannes; Trauner, Dirk

Chemical reviews. 2018 Nov 14; 118(21):10710-10747

Bamberg, Ernst; Gärtner, Wolfgang; Trauner, Dirk

Chemical reviews. 2018 Nov 14; 118(21):10627-10628