The brain is segregated from the rest of the body via the blood-brain barrier and has long been considered as an immune privileged organ. Recently, this view has shifted dramatically with increasing evidence showing a complex reciprocal relationship between the immune and nervous systems in health and disease. My laboratory studies the mechanisms by which pathological immune responses contribute to neurological disorders such as multiple sclerosis, Alzheimer's disease and chronic pain. We are also interested in the relationship between anesthetic neurotoxicity and postoperative cognitive dysfunction. The laboratory uses a combination of techniques including in vivo two-photon imaging, molecular manipulation, biochemistry and behavioral analysis to address these questions.
Associate Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine
PhD from Tsinghua University
Molecular psychiatry. 2017 Jul; 22(7):935-935
Nature neuroscience. 2017 Jun 26; 20(8):1122-1132
eLife. 2017 May 19; 6:?-?
Nature medicine. 2017 May 15; 23(6):714-722
Neurotoxicology & teratology. 2017 Mar; 60:75-81
Bio-protocol. 2017 Jan 20; 7(2):?-?
Nature neuroscience. 2017 Jan 16; 20(3):427-437
Frontiers in immunology. 2017; 8:902-902