Iannis Aifantis

Iannis Aifantis, PhD

Chair, Department of Pathology

Professor, Department of Pathology

Keywords
cancer, immunology, stem cell biology, epigenetic regulation , leukemia, tumor microenvironment
Summary

My laboratory focuses on the molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. Specifically, we study the initiation and progression of both lymphoid (T-ALL) and myeloid (AML, CML, CMML) leukemias.

Our work has identified and studied a number of novel oncogene proteins (including NOTCH1), tumor suppressor proteins (including FBXW7, TET2, CYLD, EZH2, UTX, cohesins), and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction of or affect the maintenance of the disease. Our laboratory also studies the mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. 

We currently have several areas of focus in our lab: 

  • the impact of DNA methylation on stem cell transformation
  • the mapping of long noncoding RNAs in a number of human tumors
  • the impact of three-dimensional chromosomal architecture in cancer
  • the role of stress responses in human malignancy
  • the in vivo mapping of the tumor microenvironment for acute leukemia

We have recently expanded our scope to include the regulation of tumor progression and metastasis in selected solid tumors, with an emphasis on cancer-initiation mechanisms, including protein stability, epigenetics, and the tumor microenvironment.

Academic office

550 First Avenue, Medical Sciences Building

5th Floor, Room 555

New York, NY 11217

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Pathology

Chair, Department of Pathology

PhD from Universite de Paris III.

Fanok, Melania H; Sun, Amy; Fogli, Laura K; Narendran, Vijay; Eckstein, Miriam; Kannan, Kasthuri; Dolgalev, Igor; Lazaris, Charalampos; Heguy, Adriana; Laird, Mary E; Sundrud, Mark S; Liu, Cynthia; Kutok, Jeff; Lacruz, Rodrigo S; Latkowski, Jo-Ann; Aifantis, Iannis; Odum, Niels; Hymes, Kenneth B; Goel, Swati; Koralov, Sergei B

Journal of investigative dermatology. 2017 Nov 8; ?-?

Thandapani, Palaniraja; Aifantis, Iannis

Cancer cell. 2017 Oct 09; 32(4):402-403

Characterization of Treatment Effects on the Tumor Microenvironment Using Single Cell RNA Sequencing [Meeting Abstract]

Oh, P; Hockemeyer, K; Satija, R; Aifantis, I

International journal of radiation oncology biology physics. 2017 OCT 1; 99(2):S203-S203

Wang, Eric; Aifantis, Ioannis

Cancer discovery. 2017 Oct; 7(10):1065-1066

Cimmino, Luisa; Dolgalev, Igor; Wang, Yubao; Yoshimi, Akihide; Martin, Gaelle H; Wang, Jingjing; Ng, Victor; Xia, Bo; Witkowski, Matthew T; Mitchell-Flack, Marisa; Grillo, Isabella; Bakogianni, Sofia; Ndiaye-Lobry, Delphine; Martin, Miguel Torres; Guillamot, Maria; Banh, Robert S; Xu, Mingjiang; Figueroa, Maria E; Dickins, Ross A; Abdel-Wahab, Omar; Park, Christopher Y; Tsirigos, Aristotelis; Neel, Benjamin G; Aifantis, Iannis

Cell. 2017 Aug 17; 170(6):1079-1095.e20

Hanniford, D; Moubarak, R; Imig, J; Ulloa, A; Sendra, B S; Karz, A; Osman, I; Aifantis, I; Hernando, E

Cancer research. 2017 July; Conference:(American):

AICDA DRIVES EPIGENETIC HETEROGENEITY IN GERMINAL CENTER-DERIVED LYMPHOMAS AND ACCELERATES LYMPHOMAGENESIS [Meeting Abstract]

Dominguez, PM; Teater, M; Redmond, D; Chen, Z; Ennishi, D; Scott, DW; Cimmino, L; Ghione, P; Chaudhuri, J; Gascoyne, RD; Aifantis, I; Inghirami, G; Elemento, O; Melnick, A; Shaknovich, R

Haematologica (Roma). 2017 JUN 26; 102:92-92

Gong, Yixiao; Huang, Hsuan-Ting; Liang, Yu; Trimarchi, Thomas; Aifantis, Iannis; Tsirigos, Aristotelis

BMC genomics. 2017 Jun 05; 18(1):434-434