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Jayne Raper

Jayne Raper

Adjunct Professor, Department of Microbiology

African trypanosome lytic factors, novel mediators of human innate immunity

Trypanosome Lytic Factor (TLF) has emerged as a novel arm of innate immunity that is only present in humans and select non-human primates. TLF was originally discovered in human blood as a minor form of HDL that rapidly kills the African trypanosome, Trypanosoma brucei brucei, thereby making humans resistant to infection. However, two other trypanosome species, T. b. rhodesiense and T. b. gambiense, resist killing by human TLF, thereby infecting humans and causing sleeping sickness. Interestingly, baboons can kill these human infective trypanosomes, thereby rendering baboons resistant to all trypanosome species. We have recently shown that this is due to baboon TLF. We have also recently shown that TLF can also ameliorate disease for other pathogens such as Leishmania, which is an intracellular parasite that grows inside a specialized vesicle in macrophages. Our long-term objective is to understand the overall broader role of TLF in innate immunity. Toward this goal,seek to understand the detailed mechanism by which TLF can bind to and kill an intracellular parasite like Leishmania, as well as how differences in the sequences of the components of baboon and human TLFs can give rise to protection from a broader range of pathogens. Understanding these mechanism will provide insights as to other pathogens that TLF should kill, as well as offer potential avenues to therapeutically augment or mimic TLF action.

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Fellowship, International Institute of Cellular and Molecular Pathology, Biochemistry

Fellowship, John Hopkins University, Baltimore, Biological Chemistry

Giovinazzo, Joseph A; Thomson, Russell P; Khalizova, Nailya; Zager, Patrick; Malani, Nirav; Rodriguez-Boulan, Enrique Javier; Raper, Jayne; Schreiner, Ryan

eLife. 2020 May 19; 9:

Verdi, Joseph; Zipkin, Ronnie; Hillman, Elani; Gertsch, Rahel A; Pangburn, Sarah J; Thomson, Russell; Papavasiliou, Nina; Sternberg, Jeremy; Raper, Jayne

Cell host & microbe. 2020 May 14;

Verdi, Joseph; Schaub, Charles; Thomson, Russell; Raper, Jayne

Methods in molecular biology. 2020 Mar; 2116:463-483

Pinger, Jason; Nešić, Dragana; Ali, Liaqat; Aresta-Branco, Francisco; Lilic, Mirjana; Chowdhury, Shanin; Kim, Hee-Sook; Verdi, Joseph; Raper, Jayne; Ferguson, Michael A J; Papavasiliou, F Nina; Stebbins, C Erec

Nature microbiology. 2018 Aug; 3(8):932-938

Yu, Mingyan; Muteti, Charity; Ogugo, Moses; Ritchie, William A; Raper, Jayne; Kemp, Stephen

Animal genetics. 2016 Aug; 47(4):510-1

Cooper, Anneli; Capewell, Paul; Clucas, Caroline; Veitch, Nicola; Weir, William; Thomson, Russell; Raper, Jayne; MacLeod, Annette

PLoS neglected tropical diseases. 2016 08; 10(8):e0004903

Heneghan, John F; Vandorpe, David H; Shmukler, Boris E; Giovinnazo, Joseph A; Raper, Jayne; Friedman, David J; Pollak, Martin R; Alper, Seth L

American journal of physiology. Cell physiology. 2015 Sep 01; 309(5):C332-47ajpcell.00142.2015

Thomson, Russell; Genovese, Giulio; Canon, Chelsea; Kovacsics, Daniella; Higgins, Matthew K; Carrington, Mark; Winkler, Cheryl A; Kopp, Jeffrey; Rotimi, Charles; Adeyemo, Adebowale; Doumatey, Ayo; Ayodo, George; Alper, Seth L; Pollak, Martin R; Friedman, David J; Raper, Jayne

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2014 May 20; 111(20):E2130-9