Joel D. Ernst

Joel D. Ernst, MD

Jeffrey Bergstein Professor of Medicine, Department of Medicine

Professor, Department of Microbiology

Professor, Department of Pathology

Keywords
innate and adaptive immunity to intracellular bacteria, immunity to tuberculosis, whole genome sequencing, cancer, immunology, microbiology
Summary

The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.

Learn more about the Ernst Lab.

Academic office

Alexandria Center - West Tower, 430 East 29th Street

Room 304

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Jeffrey Bergstein Professor of Medicine, Department of Medicine

Professor, Department of Microbiology

Professor, Department of Pathology

Dir Division of Infectious Dis & Immunology

Dir,Immunology and Inflammation Graduate Program

MD from University of Nebraska

Boggiano, Cesar; Eichelberg, Katrin; Ramachandra, Lakshmi; Shea, Jaqueline; Ramakrishnan, Lalita; Behar, Samuel; Ernst, Joel D; Porcelli, Steven A; Maeurer, Markus; Kornfeld, Hardy

Vaccine. 2017 May 2; 35(27):3433-3440

Arlehamn, Cecilia S Lindestam; Copin, Richard; Leary, Shay; Mack, Steven J; Phillips, Elizabeth; Mallal, Simon; Sette, Alessandro; Blatner, Gretta; Siefers, Heather; Ernst, Joel D

Human immunology. 2017 Mar 16; 78(4):325-326

Wiens, Kirsten E; Ernst, Joel D

Journal of infectious diseases. 2016 Dec 15; 214(12):1893-1896

Copin, Richard; Wang, Xueying; Louie, Eddie; Escuyer, Vincent; Coscolla, Mireia; Gagneux, Sebastien; Palmer, Guy H; Ernst, Joel D

PLoS pathogens. 2016 Dec 14; 12(12):e1006111-e1006111e1006111

Portal-Celhay, Cynthia; Tufariello, JoAnn M; Srivastava, Smita; Zahra, Aleena; Klevorn, Thais; Grace, Patricia S; Mehra, Alka; Park, Heidi S; Ernst, Joel D; Jacobs, William R Jr; Philips, Jennifer A

Nature microbiology. 2016 Dec 05; 2:16232-16232

Blumberg, Henry M; Ernst, Joel D

JAMA. 2016 Sep 06; 316(9):931-933

Wiens, Kirsten E; Ernst, Joel D

PLoS pathogens. 2016 Aug; 12(8):e1005809-e1005809e1005809

Lindestam Arlehamn, Cecilia S; McKinney, Denise M; Carpenter, Chelsea; Paul, Sinu; Rozot, Virginie; Makgotlho, Edward; Gregg, Yolande; van Rooyen, Michele; Ernst, Joel D; Hatherill, Mark; Hanekom, Willem A; Peters, Bjoern; Scriba, Thomas J; Sette, Alessandro

PLoS pathogens. 2016 Jul; 12(7):e1005760-e1005760e1005760