The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.
Learn more about the Ernst Lab.
Jeffrey Bergstein Professor of Medicine, Department of Medicine
Professor, Department of Microbiology
Professor, Department of Pathology
Dir Division of Infectious Dis & Immunology
Dir,Immunology and Inflammation Graduate Program
MD from University of Nebraska
Vaccine. 2017 May 2; 35(27):3433-3440
Human immunology. 2017 Mar 16; 78(4):325-326
Journal of infectious diseases. 2016 Dec 15; 214(12):1893-1896
PLoS pathogens. 2016 Dec 14; 12(12):e1006111-e1006111e1006111
Nature microbiology. 2016 Dec 05; 2:16232-16232
JAMA. 2016 Sep 06; 316(9):931-933
PLoS pathogens. 2016 Aug; 12(8):e1005809-e1005809e1005809
PLoS pathogens. 2016 Jul; 12(7):e1005760-e1005760e1005760