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Joel D. Oppenheim

Joel D. Oppenheim, PhD

Research Professor, Department of Microbiology

Professor Emeritus of Microbiology, Department of Microbiology

Keywords
structure and function of IgD domains
Summary

In collaboration with NYU School of Medicine colleague Dr. G.J. Thorbecke, our group seeks to elucidate the function of IgD, an immunoglobulin that, while in trace amounts in serum (less than 1% of total), is present on the surface of most B lymphocytes. Although IgD's precise biological function has not been defined, considerable evidence indicates its role in humoral immunoaugmentation. In vivo and in vitro murine studies suggest that IgD's augmentation involvement applies to primary and secondary antibody responses, with helper T cells acting as mediators of the effect. This augmentation appears to result from direct contact between IgD and a specific class of T cells expressing IgD receptors on their cell surface (T-delta cells). Such contact causes up-regulation of the IgD receptors on these T cells, allowing them to bind more strongly to B cells and facilitating B-cell activation and proliferation. In microdissection studies of purified murine and human IgD to determine the minimum molecular entity that can induce IgD receptor up-regulation on T cells, we showed that IgD immune augmentation resides solely in the carbohydrate moieties on the molecule and, in murine IgD, specifically in N-linked sequences. Continuing studies examine 1) the precise oligosaccharide sequence(s) responsible for this IgD biological activity, 2) the synthesis of such sequences, 3) the nature and specificity of the IgD receptor, and 4) the use of purified IgD, or carbohydrate sequences therefrom, to stimulate various immune responses.

Our group also develops unique protocols and techniques for purifying biologically and immunologically active proteins.

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Research Professor, Department of Microbiology

Professor Emeritus of Microbiology, Department of Microbiology

PhD from Loyola University

Fellowship, NYU School of Medicine, Microbiology

Awosogba, Temitope; Betancourt, Joseph R; Conyers, F Garrett; Estape, Estela S; Francois, Fritz; Gard, Sabrina J; Kaufman, Arthur; Lunn, Mitchell R; Nivet, Marc A; Oppenheim, Joel D; Pomeroy, Claire; Yeung, Howa

Annals of the New York Academy of Sciences. 2013 May; 1287:17-30

Ren M; Villamarin A; Shih A; Coutavas E; Moore MS; LoCurcio M; Clarke V; Oppenheim JD; D'Eustachio P; Rush MG

Molecular & cellular biology. 1995 Apr; 15(4):2117-24

Coutavas E; Ren M; Oppenheim JD; D'Eustachio P; Rush MG

Nature. 1993 Dec 09; 366(6455):585-7

Amin AR; Tamma SM; Swenson CD; Kieda CC; Oppenheim JD; Finkelman FD; Coico RF

International immunology. 1993 Jun; 5(6):607-14

Viitanen PV; Lorimer GH; Seetharam R; Gupta RS; Oppenheim J; Thomas JO; Cowan NJ

Journal of biological chemistry. 1992 Jan 15; 267(2):695-8

Amin AR; Tamma SM; Oppenheim JD; Finkelman FD; Kieda C; Coico RF; Thorbecke GJ

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 1991 Oct 15; 88(20):9238-42