In a broad sense, we design our research to understand the cerebellar contribution to sensorimotor integration by investigating in the rabbit the neuronal signal processing associated with eye movements elicited by natural stimuli. The experimental method mostly is correlating extracellularly recorded Purkinje cell activity with natural visual, vestibular, and proprioceptive stimuli and with the compensatory eye movement responses. We focus on the cerebellar flocculus and the distribution of Purkinje cell complex and simple spike activity located in anatomically distinguishable modules. The hypothesis is that cerebellar signal processing entails mapping within and between intrinsic reference frames and that these have an anatomical counterpart in the modular organization of the cerebellum.
Recent studies involve the modular organization of the cerebellar flocculus relative to eye movement control, the contribution of floccular Purkinje cells to signal encoding in medial vestibular neurons, and the evaluation of hypotheses of climbing fiber function in the context of floccular visual climbing fibers, which are modulated by retinal image motion. Two specific research projects assess the relative contribution of the ascending and parallel fiber segments of granule cell axons to the generation of Purkinje cell simple spike activity; the projects also determine how the capacity of the inferior olive to discharge synchronously and rhythmically is influenced by eye movements evoked by natural visual and vestibular stimulation.
Research Professor, Department of Neuroscience and Physiology
Professor Emeritus of Neuroscience and Physiology, Department of Neuroscience and Physiology
Cerebellum. 2015 Oct; 14(5):578-583
Journal of neuroscience methods. 2014 Jul 30; 232:173-180
Journal of neuroscience. 2014 Feb 26; 34(9):3218-3230
Cerebellum. 2011 Sep; 10(3):515-522
Journal of neuroscience. 2011 Jan 12; 31(2):712-724
Experimental brain research. 2008 Feb; 185(1):87-99
Journal of neuroscience. 2007 Oct 17; 27(42):11263-11270
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2006 Oct 31; 103(44):16550-16555