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Jose Morales-Corraliza

Jose Morales-Corraliza, PhD

Research Assistant Professor, Department of Psychiatry

Keywords
Diabetes, insulin, brain, hippocampus, Alzheimer’s disease (AD), amyloid-β (Aβ), Amyloid Precursor Protein (APP), tau
Summary

My primary research focus at NYU Langone and the Nathan S. Kline Institute for Psychiatric Research is the cellular and molecular neurobiology of mouse models of Alzheimer’s disease (AD) and other neurological conditions such as Down syndrome.

My studies integrate the analysis of tau phosphorylation and amyloid precursor protein (APP) metabolite levels in vivo and in vitro, including amyloid beta (Aβ) and APP C-terminal fragments (CTFs). My particular areas of interest include the analysis of Aβ passive vaccination, the reduction of Aβ and tau pathology by calpain inhibition, the stability of APP metabolites in the brain, and the role that CTFs play in modulating intracellular vesicle function and neuronal vulnerability.

My recent research centers on the biomolecular events that contribute to AD. Patients with diabetes are at increased risk of developing AD pathology as they age, but the biological mechanisms linking the two diseases are unclear. Based on my initial biochemical analyses on the brain regional pattern of Aβ and tau pathology in diabetes, I expanded my research interests to include the role of insulin dysregulation in the diabetic brain, especially the hippocampus, which is highly vulnerable in AD.

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Research Assistant Professor, Department of Psychiatry

PhD from Autonomous University of Madrid

Peng, Katherine Y; Pérez-González, Rocío; Alldred, Melissa J; Goulbourne, Chris N; Morales-Corraliza, Jose; Saito, Mariko; Saito, Mitsuo; Ginsberg, Stephen D; Mathews, Paul M; Levy, Efrat

Brain. 2019 Jan 01; 142(1):163-175

Morales-Corraliza, Jose; Wong, Harrison; Mazzella, Matthew J; Che, Shaoli; Lee, Sang Han; Petkova, Eva; Wagner, Janice D; Hemby, Scott E; Ginsberg, Stephen D; Mathews, Paul M

Journal of neuroscience. 2016 Apr 13; 36(15):4248-58

Mahler, Jasmin; Morales-Corraliza, Jose; Stolz, Julia; Skodras, Angelos; Radde, Rebecca; Duma, Carmen C; Eisele, Yvonne S; Mazzella, Matthew J; Wong, Harrison; Klunk, William E; Nilsson, K Peter R; Staufenbiel, Matthias; Mathews, Paul M; Jucker, Mathias; Wegenast-Braun, Bettina M

Neurobiology of aging. 2015 Jul; 36(7):2241-2247

Duffy, Aine M; Morales-Corraliza, Jose; Bermudez-Hernandez, Keria M; Schaner, Michael J; Magagna-Poveda, Alejandra; Mathews, Paul M; Scharfman, Helen E

Neurobiology of aging. 2015 Jan; 36(1):134-48

Wesson, Daniel W; Morales-Corraliza, Jose; Mazzella, Matthew J; Wilson, Donald A; Mathews, Paul M

Behavioural brain research. 2013 Jan 15; 237:96-102

Morales-Corraliza, Jose; Schmidt, Stephen D; Mazzella, Matthew J; Berger, Jason D; Wilson, Donald A; Wesson, Daniel W; Jucker, Mathias; Levy, Efrat; Nixon, Ralph A; Mathews, Paul M

Neurobiology of aging. 2013 Jan; 34(1):137-45

Choi, Jennifer H K; Kaur, Gurjinder; Mazzella, Matthew J; Morales-Corraliza, Jose; Levy, Efrat; Mathews, Paul M

Journal of Alzheimer's disease. 2013 Apr; 34(3):691-700

Morales-Corraliza, Jose; Berger, Jason D; Mazzella, Matthew J; Neubert, Thomas A; Ghiso, Jorge; Rao, Mala V; Staufenbiel, Matthias; Nixon, Ralph A; Mathews, Paul M

Neurobiology of aging. 2012 Jun; 33(6):1125.e9-18