Leslie S. Prichep

Adjunct Professor, Department of Psychiatry

Keywords
QEEG characteristics and subtyping of neuropsychiatric disorders
Summary

Using quantitative EEG (QEEG) methodology developed in this laboratory over the past 20 years, we study the profiles of abnormal QEEG features in large populations of psychiatric patients and the relationship of these profiles to treatment outcome. Results to date from our current National Institute of Drug Abuse-funded study of the pathophysiology of crack cocaine dependence reveal the existence of a characteristic profile of QEEG changes associated with cocaine dependence and demonstrate that this profile persists during 1, 6, and 9 mo of abstinence. Such findings may reflect lasting alterations in neurotransmission as a consequence of cocaine exposure. Our published pilot work, demonstrating a markedly similar pattern of QEEG abnormalities in children with histories of in utero exposure to cocaine lend further evidence for such hypotheses. In addition, subtypes with distinctive QEEG profiles have been identified at baseline within the cocaine-dependent population. Significant interactions have been found between subtype membership, gender, comorbidity, and treatment retention. Another series of studies are focused specifically on the electrophysiological heterogeneity observed in clinically homogeneous patient populations. Cluster analysis of the baseline QEEG evaluations in DSM III-R obsessive-compulsive patients revealed two subtypes. Following a 3-mo clinical trial with specific serotonin reuptake inhibitors, it was found that treatment response could be accurately predicted in over 80% of the cases, determined on baseline QEEG subtype membership. Similarly, in schizophrenic patient populations and children with attention deficit disorder, the relationship between QEEG subtype and treatment response has been shown.

 

 

These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Adjunct Professor, Department of Psychiatry

Brooks, M Alison; Bazarian, Jeffrey J; Prichep, Leslie S; Dastidar, Samanwoy Ghosh; Talavage, Thomas M; Barr, William

Journal of head trauma rehabilitation. 2018 Jan /0; 33(1):1-6

Prichep, Leslie S; Shah, Jaini; Merkin, Henry; Hiesiger, Emile M

Clinical EEG & neuroscience. 2017 Nov 6; 49(2):103-113

Hanley, Daniel; Prichep, Leslie S; Badjatia, Neeraj; Bazarian, Jeff; Chiacchierini, RIchard P; Curley, Kenneth C; Garrett, John S; Jones, Elizabeth B; Naunheim, Rosanne; O'Neil, Brian J; O'Neill, John; David, Wright; Huff, J Stephen

Journal of neurotrauma. 2017 Sep 21; 35(1):41-47

Hack, Dallas; Huff, J Stephen; Curley, Kenneth; Naunheim, Roseanne; Ghosh Dastidar, Samanwoy; Prichep, Leslie S

American journal of emergency medicine. 2017 Jul; 35(7):949-952

Hanley, Daniel; Prichep, Leslie S; Bazarian, Jeffrey; Huff, J Stephen; Naunheim, Rosanne; Garrett, John; Jones, Elizabeth; Wright, David; O'Neill, John; Badjatia, Neeraj; Gandhi, Dheeraj; Curley, Kenneth C; Chiacchierini, Richard; O'Neil, Brian; Hack, Dallas C

Academic emergency medicine. 2017 Mar 31; 24(5):617-627

Triage of mild/moderate traumatic head-injured patients using a brain electrical activity marker: A multisite prospective validation trial of clinical efficacy [Meeting Abstract]

Prichep, Leslie; Bazarian, Jeffrey; Huff, JStephen; Naunheim, Rosanne; Garrett, John; Jones, Elizabeth; Wright, David; O'Neill, John; Badjatia, Neeraj; O'Neil, Brian; Hanley, Daniel

Brain injury. 2017; 31(6-7):823-823

Evaluation of concussion in athletes using an electrophysiological brain function index [Meeting Abstract]

Prichep, Leslie; Bazarian, Jeffrey; Brooks, MAlison; Dastidar, Samanwoy Ghosh; Talavage, Thomas; Barr, William

Brain injury. 2017; 31(6-7):824-824

Diffusion tensor imaging in collegiate athletes shows effects of both concussion and exposure to contact sport [Meeting Abstract]

Wilde, E; Ware, A; Biekman, B; Taylor, B; Hollowell, L; Wu, T; Paxton, H; Prichep, L; Bouix, S; Podell, K; Schnyer, D; Newman-Norlund, R; Casa, D; Yeargin, S; Levin, H

Journal of neurotrauma. 2017; Conference:(35th):A115