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Marie E. Monaco

Associate Professor, Department of Neuroscience and Physiology

lipid metabolism and hormone resistance in breast cancer

Our laboratory is interested in the relationship between fatty acid activation and the aggressive phenotype in breast cancer. Our studies have demonstrated that expression of a specific isoform of fatty acyl-CoA synthetase (ACSL4) is negatively correlated with hormone/growth factor receptor status, and that forced expression of ACSL4 in the presence of receptors induces resistance to targeted therapies. The high expression level of ACSL4 in the most aggressive triple negative breast cancers suggests that it may comprise an appropriate target for the development of additional targeted therapies.



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New York, NY 10010

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.
Monaco, Marie E

Oncotarget. 2017 Apr 25; 8(17):29487-29500

Hon, Jane Date C; Singh, Baljit; Sahin, Aysegul; Du, Gang; Wang, Jinhua; Wang, Vincent Y; Deng, Fang-Ming; Zhang, David Y; Monaco, Marie E; Lee, Peng

American journal of cancer research. 2016 10; 6(9):1864-1872

Wu, Xinyu; Deng, Fangming; Li, Yirong; Daniels, Garrett; Du, Xinxin; Ren, Qinghu; Wang, Jinhua; Wang, Ling Hang; Yang, Yang; Zhang, Valerio; Zhang, David; Ye, Fei; Melamed, Jonathan; Monaco, Marie E; Lee, Peng

Oncotarget. 2015 Dec 29; 6(42):44849-63

Wu, Xinyu; Daniels, Garrett; Lee, Peng; Monaco, Marie E

American journal of clinical & experimental urology. 2014 Feb; 2(2):111-20

Wu, Xinyu; Li, Yirong; Wang, Jinhua; Wen, Xin; Marcus, Max T; Daniels, Garrett; Zhang, David Y; Ye, Fei; Wang, Ling Hang; Du, Xinxin; Adams, Sylvia; Singh, Baljit; Zavadil, Jiri; Lee, Peng; Monaco, Marie E

PLoS one. 2013 Dec; 8(10):e77060

Wu X; Xu K; Zhang L; Deng Y; Lee P; Shapiro E; Monaco M; Makarenkova HP; Li J; Lepor H; Grishina I

Developmental biology (Orlando). 2011 Aug 15; 356(2):337-49

Wu, Xinyu; Daniels, Garrett; Shapiro, Ellen; Xu, Kun; Huang, Hongying; Li, Yirong; Logan, Susan; Greco, M Alba; Peng, Yi; Monaco, Marie E; Melamed, Jonathan; Lepor, Herbert; Grishina, Irina; Lee, Peng

Molecular endocrinology. 2011 Jun; 25(6):1018-26

Luque, M E; Serrano, M A; Honore, S M; Monaco, M E; Sanchez, S S

Gene expression patterns. 2010 Jun; 10(4-5):207-13