Marie E. Monaco, PhD

Neuroscience Institute

Associate Professor, Department of Neuroscience and Physiology

Keywords
lipid metabolism and hormone resistance in breast cancer
Summary

Our laboratory is interested in the relationship between fatty acid activation and the aggressive phenotype in breast cancer. Our studies have demonstrated that expression of a specific isoform of fatty acyl-CoA synthetase (ACSL4) is negatively correlated with hormone/growth factor receptor status, and that forced expression of ACSL4 in the presence of receptors induces resistance to targeted therapies. The high expression level of ACSL4 in the most aggressive triple negative breast cancers suggests that it may comprise an appropriate target for the development of additional targeted therapies.

Phone

212-263-4184

Academic office

423 East 23rd Street

Fifteenth Floor

New York, NY 10010

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Neuroscience and Physiology

PhD from Columbia University

Monaco, Marie E

Oncotarget. 2017 Feb 18; ?-?

Hon, Jane Date C; Singh, Baljit; Sahin, Aysegul; Du, Gang; Wang, Jinhua; Wang, Vincent Y; Deng, Fang-Ming; Zhang, David Y; Monaco, Marie E; Lee, Peng

American journal of cancer research. 2016 Sep 1; 6(9):1864-1872

Wu, Xinyu; Deng, Fangming; Li, Yirong; Daniels, Garrett; Du, Xinxin; Ren, Qinghu; Wang, Jinhua; Wang, Ling Hang; Yang, Yang; Zhang, Valerio; Zhang, David; Ye, Fei; Melamed, Jonathan; Monaco, Marie E; Lee, Peng

Oncotarget. 2015 Dec 29; 6(42):44849-44863

Wu, Xinyu; Daniels, Garrett; Lee, Peng; Monaco, Marie E

American journal of clinical & experimental urology. 2014 Jul 12; 2(2):111-120

ACSL4 IN PROSTATE CANCER GROWTH, INVASION AND HORMONAL RESISTANCE [Meeting Abstract]

Wu, Xinyu; Li, Yirong; Du, Xinxin; Ren, Qinghu; Kong, Max X; Wang, Jinhua; Wang, LingHang; Yang, Yang; Zhang, Valerio; Zhang, David; Ye, Fei; Daniels, Garrett; Deng, Fangming; Wei, Jianjun; Melamed, Jonathan; Monaco, Marie E; Lee, Peng

Journal of urology. 2014 Apr; 191(4):E324-E324

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression [Meeting Abstract]

Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.

Modern pathology. 2013 Feb; 26(Suppl 2):243A-243A

Role of Long-Chain Fatty Acyl-CoA Synthetase 4 (ACSL4) in Prostate Cancer Progression [Meeting Abstract]

Ren, Q.; Kong, M. X.; Wu, X.; Deng, F-M; Melamed, J.; Monaco, M. E.; Lee, P.

Laboratory investigation. 2013 Feb; 93 1 1:243A-243A

Wu, Xinyu; Li, Yirong; Wang, Jinhua; Wen, Xin; Marcus, Max T; Daniels, Garrett; Zhang, David Y; Ye, Fei; Wang, Ling Hang; Du, Xinxin; Adams, Sylvia; Singh, Baljit; Zavadil, Jiri; Lee, Peng; Monaco, Marie E

PLoS one. 2013; 8(10):e77060-e77060e77060