Michael L. Dustin

Michael L. Dustin, PhD

Skirball Institute

Research Professor, Department of Pathology

Keywords
cell adhesion, T-cell activation, immunological synapse, immune cell migration, microscopy
Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Research Professor, Department of Pathology

PhD from Howard University

Balint, Stefan; Dustin, Michael L

eLife. 2017 Mar 30; 6:?-?

Lopes, Filipa B; Balint, Stefan; Valvo, Salvatore; Felce, James H; Hessel, Edith M; Dustin, Michael L; Davis, Daniel M

Journal of cell biology. 2017 Mar 13; 216(4):1123-1141

Cai, Haogang; Depoil, David; Muller, James; Sheetz, Michael P; Dustin, Michael L; Wind, Shalom J

Methods in molecular biology. 2017; 1584:307-331

Dustin, Michael L; Baldari, Cosima T

Methods in molecular biology. 2017; 1584:1-5

Fu, Wenyu; Hu, Wenhuo; Shi, Lei; Mundra, Jyoti Joshi; Xiao, GuoZhi; Dustin, Michael L; Liu, Chuan-Ju

FASEB journal. 2016 Dec 23; 31(4):1354-1367

Deng, Jing; Mitsuki, Yu-Ya; Shen, Guomiao; Ray, Jocelyn; Cicala, Claudia; Arthos, James; Dustin, Michael L; Hioe, Catarina E

Journal of virology. 2016 Dec 01; 90(23):10513-10526

Mayya, Viveka; Dustin, Michael L

Trends in immunology. 2016 Aug; 37(8):513-522

Saha, Asim; O'Connor, Roddy S; Thangavelu, Govindarajan; Lovitch, Scott B; Dandamudi, Durga Bhavani; Wilson, Caleph B; Vincent, Benjamin G; Tkachev, Victor; Pawlicki, Jan M; Furlan, Scott N; Kean, Leslie S; Aoyama, Kazutoshi; Taylor, Patricia A; Panoskaltsis-Mortari, Angela; Foncea, Rocio; Ranganathan, Parvathi; Devine, Steven M; Burrill, Joel S; Guo, Lili; Sacristan, Catarina; Snyder, Nathaniel W; Blair, Ian A; Milone, Michael C; Dustin, Michael L; Riley, James L; Bernlohr, David A; Murphy, William J; Fife, Brian T; Munn, David H; Miller, Jeffrey S; Serody, Jonathan S; Freeman, Gordon J; Sharpe, Arlene H; Turka, Laurence A; Blazar, Bruce R

Journal of clinical investigation. 2016 Jul 01; 126(7):2642-2660