Michael L. Dustin

Michael L. Dustin, PhD

Skirball Institute

Research Professor, Department of Pathology

Keywords
cell adhesion, T-cell activation, immunological synapse, immune cell migration, microscopy
Summary

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.

Phone

646-501-4509

Fax

646-501-2207

Academic office

430 East 29th Street, ACLF, West Tower

4th Floor, Admin

New York, NY 10016

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Research Professor, Department of Pathology

PhD from Harvard University

Washington University in St. Louis, Stuart Kornfeld, Division of Hematology and Oncology, Dept of Medicine

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

Inbar, A -A; Strazza, M; Peled, M; Novak, H K; Muller, J; Dustin, M L; Mor, A

Science signaling. 2017 Aug 08; 10(491):aal2880

Azoulay-Alfaguter, Inbar; Strazza, Marianne; Peled, Michael; Novak, Hila K; Muller, James; Dustin, Michael L; Mor, Adam

Science signaling. 2017 Aug 8; 10(491):?-?

Jang, Jung-Eun; Hajdu, Cristina H; Liot, Caroline; Miller, George; Dustin, Michael L; Bar-Sagi, Dafna

Cell reports. 2017 Jul 18; 20(3):558-571

Zanin-Zhorov, Alexandra; Kumari, Sudha; Hippen, Keli L; Merkel, Sarah C; MacMillan, Margaret L; Blazar, Bruce R; Dustin, Michael L

Scientific reports. 2017 Jun 26; 7(1):4258-4258

Mendoza, Alejandra; Fang, Victoria; Chen, Cynthia; Serasinghe, Madhavika; Verma, Akanksha; Muller, James; Chaluvadi, V Sai; Dustin, Michael L; Hla, Timothy; Elemento, Olivier; Chipuk, Jerry E; Schwab, Susan R

Nature. 2017 May 24; 546(7656):158-161

Balint, Stefan; Dustin, Michael L

eLife. 2017 Mar 30; 6:?-?

Lopes, Filipa B; Balint, Stefan; Valvo, Salvatore; Felce, James H; Hessel, Edith M; Dustin, Michael L; Davis, Daniel M

Journal of cell biology. 2017 Mar 13; 216(4):1123-1141

Cai, Haogang; Depoil, David; Muller, James; Sheetz, Michael P; Dustin, Michael L; Wind, Shalom J

Methods in molecular biology. 2017; 1584:307-331