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Michael L. Dustin

Michael L. Dustin, PhD

Skirball Institute

Research Professor, Department of Pathology

cell adhesion, T-cell activation, immunological synapse, immune cell migration, microscopy

Immunological synapses are stable T cell-antigen presenting cell junctions that are mediated by bona fide adhesion molecules and lead to vector communication. Immunological synapses are maintained by symmetrical centripetal actin flow within the T cell in the in the plane of the contact with the antigen presenting cell. If this symmetry is broken the T cell initiates migration, but can still gather information though a kinapse, a mobile cell-cell junction mediated by adhesion molecules based on retrograde actin flow in the plane of contact with the antigen presenting cell. We also study the process of immune cell communication in vivo. Topics include regulation of T cell migration in lymph nodes and the spleen by antigen recognition, the regulation of innate T cell lipid recognition in the liver, the competition between B cells in Germinal Centers that leads to high affinity antibody production, immune cell interactions within the central nervous system and gut.





Academic office

430 East 29th Street, ACLF, West Tower

4th Floor, Admin

New York, NY 10016

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PhD from Harvard University

Washington University in St. Louis, Stuart Kornfeld, Division of Hematology and Oncology, Dept of Medicine

Demetriou, Philippos; Abu-Shah, Enas; Valvo, Salvatore; McCuaig, Sarah; Mayya, Viveka; Kvalvaag, Audun; Starkey, Thomas; Korobchevskaya, Kseniya; Lee, Lennard Y W; Friedrich, Matthias; Mann, Elizabeth; Kutuzov, Mikhail A; Morotti, Matteo; Wietek, Nina; Rada, Heather; Yusuf, Shamsideen; Afrose, Jehan; Siokis, Anastasios; Meyer-Hermann, Michael; Ahmed, Ahmed Ashour; Depoil, David; Dustin, Michael L

Nature immunology. 2020 Oct; 21(10):1232-1243

Céspedes, Pablo F; Beckers, Daniel; Dustin, Michael L; Sezgin, Erdinc

FEBS journal. 2020 Jul 18;

Harrison, Thomas E; Mørch, Alexander M; Felce, James H; Sakoguchi, Akihito; Reid, Adam J; Arase, Hisashi; Dustin, Michael L; Higgins, Matthew K

Nature. 2020 Jul 10;

Bálint, Š; Müller, S; Fischer, R; Kessler, B M; Harkiolaki, M; Valitutti, S; Dustin, M L

Science. 2020 05 22; 368(6493):897-901

Dustin, Michael L; Zenclussen, Ana C

Journal of biological chemistry. 2020 Apr 03; 295(14):4381-4382

Kumari, Sudha; Mak, Michael; Poh, Yeh-Chuin; Tohme, Mira; Watson, Nicki; Melo, Mariane; Janssen, Erin; Dustin, Michael; Geha, Raif; Irvine, Darrell J

EMBO journal. 2020 Mar 02; 39(5):e102783

Coomer, Charles A; Carlon-Andres, Irene; Iliopoulou, Maro; Dustin, Michael L; Compeer, Ewoud B; Compton, Alex A; Padilla-Parra, Sergi

PLoS pathogens. 2020 Feb 21; 16(2):e1008359

Zanin-Zhorov, Alexandra; Kumari, Sudha; Hippen, Keli L; Merkel, Sarah C; MacMillan, Margaret L; Blazar, Bruce R; Dustin, Michael L

Scientific reports. 2020 Feb 19; 10(1):3317