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Miroslav Blumenberg

Miroslav Blumenberg, PhD

Associate Professor, Ronald O. Perelman Department of Dermatology

Associate Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
molecular biology and genetics of human keratin genes, transcriptional profiling of skin cells using DNA microarrays, effects of UV light on skin, signal transduction in skin during inflammatory and proliferative processes, epidermal stem cells and differentiation
Summary


DNA microarrays allow us to follow global cellular responses to various agents. Using UV light as a paradigmatic damaging agent, we determined that cells make following responses: 1. They change signal transduction and transcription regulators, basically stop what they have been doing and respond to UV. 2. Produce cytokines and chemokine to alert the surrounding tissue to the damage. 3. Produce more energy by increasing mitochondrial proteins and suppressing proteins that use energy. 4. Increase the cornified layer that protects the skin. These responses protect not only the cells, but also the underlying tissues of the organism.

In another study, we described the antiviral effects of Interferon-gamma in skin. Specifically, we found that IFNg suppresses cell cycle and DNA replication ? the cell that does not replicate its own DNA will not replicate the viral either; IFNg boosts tight junction proteins, impeding para-cellular viral entry into the organism, and suppresses epidermal differentiation, which inhibits proliferation of papilloma viruses.
We are extending our studies to other agents that affect skin biology, such as proinflammatory cytokines, DNA damaging agents etc. Recently, we have started a program focused on epidermal stem cells and differentiation. Our goal is to describe the global molecular responses of skin to its environment.

Phone

212-263-5924

Fax

212-263-7390

Academic office

455 First Avenue

8th Floor, Suite 843C

New York, NY 10016

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Associate Professor, Ronald O. Perelman Department of Dermatology

Associate Professor, Department of Biochemistry and Molecular Pharmacology

PhD from Massachusetts Institute of Technology

Blumenberg, Miroslav

Seminars in cutaneous medicine & surgery. 2019 Mar 01; 38(1):E12-E18

Clancy, Robert M; Markham, Androo J; Jackson, Tanisha; Rasmussen, Sara E; Blumenberg, Miroslav; Buyon, Jill P

American journal of physiology. Heart & circulatory physiology. 2017 Sep 01; 313(3):H631-H640ajpheart.00256.2017

Young, Christina A; Eckert, Richard L; Adhikary, Gautam; Crumrine, Debra; Elias, Peter M; Blumenberg, Miroslav; Rorke, Ellen A

Journal of investigative dermatology. 2017 09; 137(9):1868-1877

Stone, Rivka C; Stojadinovic, Olivera; Rosa, Ashley M; Ramirez, Horacio A; Badiavas, Evangelos; Blumenberg, Miroslav; Tomic-Canic, Marjana

Science translational medicine. 2017 01 04; 9(371):

Palazzo, E; Kellett, M; Cataisson, C; Gormley, A; Bible, P W; Pietroni, V; Radoja, N; Hwang, J; Blumenberg, M; Yuspa, S H; Morasso, M I

Oncogene. 2016 06 16; 35(24):3114-24

Kiss, Alexi; Koppel, Aaron C; Anders, Joanna; Cataisson, Christophe; Yuspa, Stuart H; Blumenberg, Miroslav; Efimova, Tatiana

Molecular carcinogenesis. 2016 May; 55(5):563-74

Clancy, Robert M; Markham, Androo J; Reed, Joanne H; Blumenberg, Miroslav; Halushka, Marc K; Buyon, Jill P

Journal of autoimmunity. 2016 Feb; 67:36-45