Philipp Leucht

Philipp Leucht, MD, PhD

Assistant Professor, Department of Orthopaedic Surgery

Assistant Professor, Department of Cell Biology

Keywords
bone biology, fracture healing, regeneration, osteoprogenitor cell, osteoblast, stem cell biology
Summary

Dr. Leucht has finished his residency and fellowship training at Stanford University and is now starting a career as a clinician scientist at New York University Langone Medical Center. He started his clinician scientist career in 2004 when he joined the laboratory of Dr. Jill Helms at Stanford. In this environment he concentrated his efforts on the basic science and translational research focused on (1) determining the underlying cell and molecular regulatory mechanisms involved in skeletal development and fracture repair, (2) investigating the role of the mechanical environment during fracture repair, and (3) stem cell-based tissue engineering strategies to enhance bone regeneration. Dr. Leucht’s expertise and skills include in vivo fracture healing models in mouse, rat and rabbit, bone histomorphometry, genetically modified mouse models, in situ hybridization, microCT analysis, and routine cell and molecular biology techniques.

He was recently funded by the OREF to examine the effect of liposomal Wnt3a, a pro-osteogenic protein, on aged bone grafts. This line of work integrates basic science research in the field of bone regeneration with a relatively new target indication: enhancing the osteogenic potential of aged bone autograft. Future studies will be aimed at understanding the interface between the mechanical environment and the biological response during treatment of segmental bone defects.

Many adult tissues harbor stem cells, which theoretically could be employed for injury repair, but the origins of these cells, and the factors that influence their developmental potency, are poorly understood. A study funded by the Musculoskeletal Transplant Foundation (MTF) will address these questions in the context of skeletal tissue regeneration.

As an orthopaedic traumatologist, Dr. Leucht's long-term goal is to use the knowledge gained from basic research to improve fracture management. His special interest lies in the molecular and cellular mechanisms that regulate skeletal repair.

Phone

646-501-0291

Lab Website
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Assistant Professor, Department of Orthopaedic Surgery

Assistant Professor, Department of Cell Biology

Konda, Sanjit R; Christiano, Anthony; Fisher, Nina; Leucht, Philipp; Egol, Kenneth A

Journal of orthopaedic trauma. 2017 Aug; 31 Suppl 3:S19-S20

Driesman, Adam; Fisher, Nina; Konda, Sanjit R; Pean, Christian A; Leucht, Philipp; Egol, Kenneth A

Archives of orthopaedic & trauma surgery. 2017 Jul 26; ?-?

Manoli, Arthur 3rd; Driesman, Adam; Marwin, Rebecca A; Konda, Sanjit; Leucht, Philipp; Egol, Kenneth A

Journal of bone & joint surgery (American volume). 2017 Jul 5; 99(13):e68-e68e68

Bradaschia-Correa, Vivian; Josephson, Anne M; Egol, Alexander J; Mizrahi, Matthew M; Leclerc, Kevin; Huo, Jason; Cronstein, Bruce N; Leucht, Philipp

Tissue & cell. 2017 Jul 4; ?-?

Saleh, Hesham; Driesman, Adam; Fisher, Nina; Leucht, Philipp; Konda, Sanjit; Egol, Kenneth

Journal of orthopaedic trauma. 2017 Jun; 31(6):e173-e178

Regan, Deirdre K; Davidovitch, Roy I; Konda, Sanjit; Manoli, Arthur 3rd; Leucht, Philipp; Egol, Kenneth A

Journal of orthopaedic trauma. 2017 May; 31(5):e143-e147

Effect of aminocaproic acid on endochondral and intramembranous bone formation during fracture healing in mice [Meeting Abstract]

Bravo, D; Josephson, A M; Bradaschia-Correa, V; Huo, J; Neibart, S; Leucht, P

Journal of orthopaedic research. 2017 March; Conference:(2017):

Periosteal progenitor cells from the cranial and appendicular skeleton exhibit unique transcriptional signatures [Meeting Abstract]

Correa, V B; Neibart, S S; Josephson, A M; Leucht, P

Journal of orthopaedic research. 2017 March; Conference:(2017):