Png Loke

Png Loke, PhD

Associate Professor, Department of Microbiology

Keywords
host pathogen interactions, helminth infection, transcriptional profiling, immune regulation, macrophage biology, immunology, microbiology
Summary

Our goal is to better understand the mechanisms by which macrophages regulate immune responses, especially in the context of helminth infection. Macrophages are a key component of our innate and adaptive immune responses and are also crucial for various aspects of tissue homeostasis (eg. wound healing, tissue repair and clearance of apoptotic cells). While macrophages were originally appreciated for their anti-microbial activities, they have more recently been acknowledged as important immuno-regulatory cells that can control unwanted inflammation. We have shown that helminths can induce a population of immuno-suppressive macrophages that are dependent on Th2 cytokines, also called alternatively activated macrophages. Alternatively activated macrophages are particularly important in immune-regulation during helminth infections. Our work is mainly focused on tissue dwelling helminth parasites that cause schistosomiasis and lymphatic filariasis. More than 200 million people worldwide are afflicted with schistosomiasis and more than 120 million people are infected with filariasis. These are neglected diseases that cause enormous morbidity to populations predominantly in the developing world. We use the mouse model of Schistosoma mansoni as our main model system for studying the regulation of immuno-pathogenesis in vivo by alternatively activated macrophages. We also use the mouse model of Brugia malayi for studying the recruitment and differentiation of alternatively activated macrophages. Infection with the adult stage of this parasite can recruit large numbers of in vivo derived alternatively activated macrophages into the peritoneal cavity for easy isolation and characterization. We are now actively characterizing the molecular mechanisms by which they regulate inflammation. Of particular interest to us is their role in regulating mucosal immunity. In addition to mouse models of helminth infection, we have been characterizing an individual who self infected with Trichuris trichiura to treat his symptoms of ulcerative colitis in order to better understand how helminths could suppress inflammatory bowel diseases.

Phone

646-501-4649

Academic office

430 East 29th Street

New York, NY 10016

Lab Website
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Associate Professor, Department of Microbiology

Fellowship, University of California, Berkeley, Immunology

Fellowship, University of California, San Francisco, Parasite Immunology

Harris, Nicola L; Loke, P'ng

Immunity. 2017 Dec 19; 47(6):1024-1036

Gotz, Anton; Tang, Mei San; Ty, Maureen C; Arama, Charles; Ongoiba, Aissata; Doumtabe, Didier; Traore, Boubacar; Crompton, Peter D; Loke, P'ng; Rodriguez, Ana

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 Nov 21; 114(49):E10568-E10577

Tang, Mei San; Bowcutt, Rowann; Leung, Jacqueline M; Wolff, Martin J; Gundra, Uma M; Hudesman, David; Malter, Lisa B; Poles, Michael A; Chen, Lea Ann; Pei, Zhiheng; Neto, Antonio G; Abidi, Wasif M; Ullman, Thomas; Mayer, Lloyd; Bonneau, Richard A; Cho, Ilseung; Loke, P'ng

Inflammatory bowel diseases. 2017 Sep; 23(9):1544-1554

Loke, P'ng; Niewold, Timothy B

Arteriosclerosis, thrombosis, & vascular biology. 2017 Aug; 37(8):1423-1424

Rahman, Karishma; Vengrenyuk, Yuliya; Ramsey, Stephen A; Vila, Noemi Rotllan; Girgis, Natasha M; Liu, Jianhua; Gusarova, Viktoria; Gromada, Jesper; Weinstock, Ada; Moore, Kathryn J; Loke, P'ng; Fisher, Edward A

Journal of clinical investigation. 2017 Jun 26; 127(8):2904-2915

Gundra, Uma Mahesh; Girgis, Natasha M; Gonzalez, Michael A; San Tang, Mei; Van Der Zande, Hendrik J P; Lin, Jian-Da; Ouimet, Mireille; Ma, Lily J; Poles, Jordan; Vozhilla, Nikollaq; Fisher, Edward A; Moore, Kathryn J; Loke, P'ng

Nature immunology. 2017 Apr 24; 18(6):642-653

Chua, Ling Ling; Rajasuriar, Reena; Azanan, Mohamad Shafiq; Abdullah, Noor Kamila; Tang, Mei San; Lee, Soo Ching; Woo, Yin Ling; Lim, Yvonne Ai Lian; Ariffin, Hany; Loke, P'ng

Microbiome. 2017 Mar 20; 5(1):35-35

Loke, P'ng; Lim, Yvonne A L

Cell host & microbe. 2016 Oct 12; 20(4):417-419

A Gut Parasite Helps Fight Inflammatory Bowel Disease