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Png Loke

Png Loke, PhD

Adjunct Associate Professor, Department of Microbiology

Keywords
host pathogen interactions, helminth infection, transcriptional profiling, immune regulation, macrophage biology, immunology, microbiology
Summary

Our goal is to better understand the mechanisms by which macrophages regulate immune responses, especially in the context of helminth infection. Macrophages are a key component of our innate and adaptive immune responses and are also crucial for various aspects of tissue homeostasis (eg. wound healing, tissue repair and clearance of apoptotic cells). While macrophages were originally appreciated for their anti-microbial activities, they have more recently been acknowledged as important immuno-regulatory cells that can control unwanted inflammation. We have shown that helminths can induce a population of immuno-suppressive macrophages that are dependent on Th2 cytokines, also called alternatively activated macrophages. Alternatively activated macrophages are particularly important in immune-regulation during helminth infections. Our work is mainly focused on tissue dwelling helminth parasites that cause schistosomiasis and lymphatic filariasis. More than 200 million people worldwide are afflicted with schistosomiasis and more than 120 million people are infected with filariasis. These are neglected diseases that cause enormous morbidity to populations predominantly in the developing world. We use the mouse model of Schistosoma mansoni as our main model system for studying the regulation of immuno-pathogenesis in vivo by alternatively activated macrophages. We also use the mouse model of Brugia malayi for studying the recruitment and differentiation of alternatively activated macrophages. Infection with the adult stage of this parasite can recruit large numbers of in vivo derived alternatively activated macrophages into the peritoneal cavity for easy isolation and characterization. We are now actively characterizing the molecular mechanisms by which they regulate inflammation. Of particular interest to us is their role in regulating mucosal immunity. In addition to mouse models of helminth infection, we have been characterizing an individual who self infected with Trichuris trichiura to treat his symptoms of ulcerative colitis in order to better understand how helminths could suppress inflammatory bowel diseases.

Phone

646-501-4649

Academic office

430 East 29th Street

AW 3rd. Floor, , # 314

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Fellowship, University of California, Berkeley, Immunology

Fellowship, University of California, San Francisco, Parasite Immunology

Fu, Wenyu; Hu, Wenhuo; Yi, Young-Su; Hettinghouse, Aubryanna; Sun, Guodong; Bi, Yufei; He, Wenjun; Zhang, Lei; Gao, Guanmin; Liu, Jody; Toyo-Oka, Kazuhito; Xiao, Guozhi; Solit, David B; Loke, Png; Liu, Chuan-Ju

Journal of clinical investigation. 2021 08 16; 131(16):

Chenery, Alistair L; Rosini, Silvia; Parkinson, James E; Ajendra, Jesuthas; Herrera, Jeremy A; Lawless, Craig; Chan, Brian Hk; Loke, P'ng; MacDonald, Andrew S; Kadler, Karl E; Sutherland, Tara E; Allen, Judith E

Life science alliance. 2021 08; 4(8):

Devlin, Joseph C; Axelrad, Jordan; Hine, Ashley M; Chang, Shannon; Sarkar, Suparna; Lin, Jian-Da; Ruggles, Kelly V; Hudesman, David; Cadwell, Ken; Loke, P'ng

Gastroenterology. 2021 Apr; 160(5):1679-1693

Lee, Soo Ching; Tang, Mei San; Lim, Yvonne A L; Choy, Seow Huey; Kurtz, Zachary D; Cox, Laura M; Gundra, Uma Mahesh; Cho, Ilseung; Bonneau, Richard; Blaser, Martin J; Chua, Kek Heng; Loke, P'ng

PLoS neglected tropical diseases. 2021 Apr; 15(4):e0009325

Liu, Menghan; Devlin, Joseph C; Hu, Jiyuan; Volkova, Angelina; Battaglia, Thomas W; Ho, Melody; Asplin, John R; Byrd, Allyson; Loke, P'ng; Li, Huilin; Ruggles, Kelly V; Tsirigos, Aristotelis; Blaser, Martin J; Nazzal, Lama

eLife. 2021 03 26; 10:

Weinstock, Ada; Rahman, Karishma; Yaacov, Or; Nishi, Hitoo; Menon, Prashanthi; Nikain, Cyrus A; Garabedian, Michela L; Pena, Stephanie; Akbar, Naveed; Sansbury, Brian E; Heffron, Sean P; Liu, Jianhua; Marecki, Gregory; Fernandez, Dawn; Brown, Emily J; Ruggles, Kelly V; Ramsey, Stephen; Giannarelli, Chiara; Spite, Matthew; Choudhury, Robin P; Loke, P'ng; Fisher, Edward A

eLife. 2021 03 15; 10:

van der Zande, Hendrik J P; Gonzalez, Michael A; de Ruiter, Karin; Wilbers, Ruud H P; García-Tardón, Noemí; van Huizen, Mariska; van Noort, Kim; Pelgrom, Leonard R; Lambooij, Joost M; Zawistowska-Deniziak, Anna; Otto, Frank; Ozir-Fazalalikhan, Arifa; van Willigen, Danny; Welling, Mick; Poles, Jordan; van Leeuwen, Fijs; Hokke, Cornelis H; Schots, Arjen; Yazdanbakhsh, Maria; Loke, P'ng; Guigas, Bruno

FASEB journal. 2021 Feb; 35(2):e21331

Lee, June-Yong; Hall, Jason A; Kroehling, Lina; Wu, Lin; Najar, Tariq; Nguyen, Henry H; Lin, Woan-Yu; Yeung, Stephen T; Silva, Hernandez Moura; Li, Dayi; Hine, Ashley; Loke, P'ng; Hudesman, David; Martin, Jerome C; Kenigsberg, Ephraim; Merad, Miriam; Khanna, Kamal M; Littman, Dan R

Cell. 2020 Dec 23; 183(7):2036-2039