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Ramin Herati

Ramin Herati, MD

Assistant Professor, Department of Medicine

Assistant Professor, Department of Microbiology

Keywords
Germinal centers, Vaccine responses, T follicular helper CD4 cells, Rational vaccines, Aging
Summary

Antibody responses are at the core of nearly every vaccine in clinical use today, yet our ability to rationally direct the antibody response remains limited. No strategies currently exist to selectively manipulate the antibody response. During an antibody response, T follicular helper CD4 cells (Tfh) provide critical help and direction to B cells. Over the past several years, we have developed approaches to look at Tfh in circulation and in tissue after vaccination. From these studies, we learned that circulating Tfh are a long-lived memory T cell population and can provide a "window" into the environment of the lymph node. We are interested in how Tfh repertoire is maintained, how the overall inflammatory environment shapes the T-B cell interaction, and how immunomodulatory therapeutics can be used to directly manipulate Tfh activity in research subjects. Understanding the T cells at the heart of a vaccine response will be crucial to designing personalized, rational vaccine strategies as well as myriad other scenarios where antibody responses are key. 

Phone

646-754-2683

Academic office

430 E 29th St, Alexandria Building - West

3rd Floor, Room 314

New York City, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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MD from Washington University

Fellowship, University of Pennsyvlania, Infectious Diseases

Residency, Johns Hopkins Bayview Medical Center, Internal Medicine

Herati, Ramin Sedaghat; Muselman, Alexander; Vella, Laura; Bengsch, Bertram; Parkhouse, Kaela; Del Alcazar, Daniel; Kotzin, Jonathan; Doyle, Susan A; Tebas, Pablo; Hensley, Scott E; Su, Laura F; Schmader, Kenneth E; Wherry, E John

Science immunology. 2017 Feb; 2(8):

Vella, Laura A; Buggert, Marcus; Manne, Sasikanth; Herati, Ramin S; Sayin, Ismail; Kuri-Cervantes, Leticia; Bukh Brody, Irene; O'Boyle, Kaitlin C; Kaprielian, Hagop; Giles, Josephine R; Nguyen, Son; Muselman, Alexander; Antel, Jack P; Bar-Or, Amit; Johnson, Matthew E; Canaday, David H; Naji, Ali; Ganusov, Vitaly V; Laufer, Terri M; Wells, Andrew D; Dori, Yoav; Itkin, Maxim G; Betts, Michael R; Wherry, E John

Journal of clinical investigation. 2019 07 02; 129(8):3185-3200

Chen, Zeyu; Ji, Zhicheng; Ngiow, Shin Foong; Manne, Sasikanth; Cai, Zhangying; Huang, Alexander C; Johnson, John; Staupe, Ryan P; Bengsch, Bertram; Xu, Caiyue; Yu, Sixiang; Kurachi, Makoto; Herati, Ramin S; Vella, Laura A; Baxter, Amy E; Wu, Jennifer E; Khan, Omar; Beltra, Jean-Christophe; Giles, Josephine R; Stelekati, Erietta; McLane, Laura M; Lau, Chi Wai; Yang, Xiaolu; Berger, Shelley L; Vahedi, Golnaz; Ji, Hongkai; Wherry, E John

Immunity. 2019 Nov 19; 51(5):840-855.e5

Huang, Alexander C; Orlowski, Robert J; Xu, Xiaowei; Mick, Rosemarie; George, Sangeeth M; Yan, Patrick K; Manne, Sasikanth; Kraya, Adam A; Wubbenhorst, Bradley; Dorfman, Liza; D'Andrea, Kurt; Wenz, Brandon M; Liu, Shujing; Chilukuri, Lakshmi; Kozlov, Andrew; Carberry, Mary; Giles, Lydia; Kier, Melanie W; Quagliarello, Felix; McGettigan, Suzanne; Kreider, Kristin; Annamalai, Lakshmanan; Zhao, Qing; Mogg, Robin; Xu, Wei; Blumenschein, Wendy M; Yearley, Jennifer H; Linette, Gerald P; Amaravadi, Ravi K; Schuchter, Lynn M; Herati, Ramin S; Bengsch, Bertram; Nathanson, Katherine L; Farwell, Michael D; Karakousis, Giorgos C; Wherry, E John; Mitchell, Tara C

Nature medicine. 2019 03; 25(3):454-461

Sayin, Ismail; Radtke, Andrea J; Vella, Laura A; Jin, Wenjie; Wherry, E John; Buggert, Marcus; Betts, Michael R; Herati, Ramin S; Germain, Ronald N; Canaday, David H

Journal of experimental medicine. 2018 06 04; 215(6):1531-1542

Buggert, Marcus; Nguyen, Son; Salgado-Montes de Oca, Gonzalo; Bengsch, Bertram; Darko, Samuel; Ransier, Amy; Roberts, Emily R; Del Alcazar, Daniel; Brody, Irene Bukh; Vella, Laura A; Beura, Lalit; Wijeyesinghe, Sathi; Herati, Ramin S; Del Rio Estrada, Perla M; Ablanedo-Terrazas, Yuria; Kuri-Cervantes, Leticia; Sada Japp, Alberto; Manne, Sasikanth; Vartanian, Shant; Huffman, Austin; Sandberg, Johan K; Gostick, Emma; Nadolski, Gregory; Silvestri, Guido; Canaday, David H; Price, David A; Petrovas, Constantinos; Su, Laura F; Vahedi, Golnaz; Dori, Yoav; Frank, Ian; Itkin, Maxim G; Wherry, E John; Deeks, Steven G; Naji, Ali; Reyes-Terán, Gustavo; Masopust, David; Douek, Daniel C; Betts, Michael R

Science immunology. 2018 06 01; 3(24):

Bengsch, Bertram; Ohtani, Takuya; Khan, Omar; Setty, Manu; Manne, Sasikanth; O'Brien, Shaun; Gherardini, Pier Federico; Herati, Ramin Sedaghat; Huang, Alexander C; Chang, Kyong-Mi; Newell, Evan W; Bovenschen, Niels; Pe'er, Dana; Albelda, Steven M; Wherry, E John

Immunity. 2018 05 15; 48(5):1029-1045.e5