Ruth Lehmann

Ruth Lehmann, PhD

Chair, Department of Cell Biology

Director, Skirball Institute of Biomolecular Medicine

Laura and Isaac Perlmutter Professor of Cell Biology, Department of Cell Biology

germ cell development, translational regulation, RNA localization and transport, germ plasm assembly, cell migration, germ line stem cells, piRNAs, transposable elements, Wolbachia, cancer, developmental genetics, genome integrity, RNA biology, stem cell biology

In most organisms, primordial germ cells (PGCs) are set-aside early during embryogenesis. Subsequently, PGCs migrate through the embryo, associate with somatic gonadal cells and form the gonad. While PGCs seem highly specialized, their products are the ultimate stem cells that generate a complete organism generation after generation. Our long-term goal is to functionally dissect the germ cell life cycle in Drosophila. Projects in the lab focus on three areas. 1) PGC specification. Early Drosophila germ cells form in a specialized germplasm and upon formation are transcriptionally silent. We are interested how RNAs localized to germ plasm are regulated and contribute to germ cell formation and fate, how gene expression is regulated during germ cell development and how the reproductive success of individual PGCs is determined. 2) PGC migration. Taking advantage of in vitro migration assays and live imaging, we study molecular and cellular aspects of germ cell migration to understand how the migratory program is established, how phospholipid signals contribute guidance cues to PGCs and how PGCs cease migration once they reach the somatic gonad. 3) Germ cell genome protection. Germ cells give rise to a new generation, thus integrity of the germ cell genome has to be protected while at the same time there has to be room for improvement via mutation and recombination. We study how host mechanisms evolved to protect the genome against transposable elements and how other intruders such as bacteria influence germ line function and reproductive success.



Academic office

540-562 First Avenue, Skirball Institute

Fourth Floor

New York, NY 10016

Lab Website
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Laura and Isaac Perlmutter Professor of Cell Biology, Department of Cell Biology

Chair, Department of Cell Biology

Director, Skirball Institute of Biomolecular Medicine

PhD from University Tubingen

Abrams, John M.; Arkhipova, Irina R.; Belfort, Marlene; Boeke, Jef D.; Curcio, M. Joan; Faulkner, Geoffrey J.; Goodier, John L.; Lehmann, Ruth; Levin, Henry L.

Mobile DNA. 2018 JUN 22; 9:?-?

Coux, Rémi-Xavier; Teixeira, Felipe Karam; Lehmann, Ruth

Development. 2018 Apr 04; 145(7):

Teixeira, Felipe Karam; Okuniewska, Martyna; Malone, Colin D; Coux, Rémi-Xavier; Rio, Donald C; Lehmann, Ruth

Nature. 2017 Dec 14; 552(7684):268-272

Greider, Carol; Hopkins, Nancy; Steitz, Joan; Amon, Angelika; Asai, David; Barres, Ben; Bass, Brenda; Bassler, Bonnie; Birgeneau, Robert; Bjorkman, Pamela; Botchan, Michael; Brugge, Joan; Cech, Tom; Colwell, Rita; Craig, Nancy; deLange, Titia; Eisen, Michael; Gottesman, Susan; Green, Rachel; Handelsman, Jo; Kimble, Judith; King, Mary-Claire; Lehmann, Ruth; Marder, Eve; Mullins, Dyche; O'Shea, Erin; Schmid, Sandra; Seydoux, Geraldine; Spradling, Allan; Storz, Gisela; Szostak, Jack; Telesnitsky, Alice; Tilghman, Shirley; Tjian, Robert; Vale, Ronald; Wolberger, Cynthia; Zakian, Virginia

Science. 2017 09 15; 357(6356):1105-1106

Pae, Juhee; Cinalli, Ryan M; Marzio, Antonio; Pagano, Michele; Lehmann, Ruth

Developmental cell. 2017 Jul 24; 42(2):130-142.e7

LeBlanc, Michelle G; Lehmann, Ruth

Journal of cell biology. 2017 Jul 7; 216(9):2945-2958

Trcek, Tatjana; Lionnet, Timothee; Shroff, Hari; Lehmann, Ruth

Nature protocols. 2017 Jul; 12(7):1326-1348

Trcek, Tatjana; Lehmann, Ruth

eLife. 2017 Jan 24; 6: