Ruth Lehmann

Ruth Lehmann, PhD

Chair, Department of Cell Biology

Director, Skirball Institute of Biomolecular Medicine

Laura and Isaac Perlmutter Professor of Cell Biology, Department of Cell Biology

Keywords
germ cell development, translational regulation, RNA localization and transport, germ plasm assembly, cell migration, germ line stem cells, piRNAs, transposable elements, Wolbachia, cancer, developmental genetics, genome integrity, RNA biology, stem cell biology
Summary

In most organisms, primordial germ cells (PGCs) are set-aside early during embryogenesis. Subsequently, PGCs migrate through the embryo, associate with somatic gonadal cells and form the gonad. While PGCs seem highly specialized, their products are the ultimate stem cells that generate a complete organism generation after generation. Our long-term goal is to functionally dissect the germ cell life cycle in Drosophila. Projects in the lab focus on three areas. 1) PGC specification. Early Drosophila germ cells form in a specialized germplasm and upon formation are transcriptionally silent. We are interested how RNAs localized to germ plasm are regulated and contribute to germ cell formation and fate, how gene expression is regulated during germ cell development and how the reproductive success of individual PGCs is determined. 2) PGC migration. Taking advantage of in vitro migration assays and live imaging, we study molecular and cellular aspects of germ cell migration to understand how the migratory program is established, how phospholipid signals contribute guidance cues to PGCs and how PGCs cease migration once they reach the somatic gonad. 3) Germ cell genome protection. Germ cells give rise to a new generation, thus integrity of the germ cell genome has to be protected while at the same time there has to be room for improvement via mutation and recombination. We study how host mechanisms evolved to protect the genome against transposable elements and how other intruders such as bacteria influence germ line function and reproductive success.

Phone

212-263-2989

Academic office

540-562 First Avenue, Skirball Institute

Fourth Floor

New York, NY 10016

Lab Website
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Laura and Isaac Perlmutter Professor of Cell Biology, Department of Cell Biology

Chair, Department of Cell Biology

Director, Skirball Institute of Biomolecular Medicine

PhD from University Tubingen

Grobler, Yolande; Yun, Chi Y; Kahler, David J; Bergman, Casey M; Lee, Hangnoh; Oliver, Brian; Lehmann, Ruth

PLoS pathogens. 2018 Nov 13; 14(11):e1007445-e1007445

Lehmann, Ruth

Annual review of cell & developmental biology. 2018 Oct 06; 34:v-viii

Kistler, Kathryn E; Trcek, Tatjana; Hurd, Thomas R; Chen, Ruoyu; Liang, Feng-Xia; Sall, Joseph; Kato, Masato; Lehmann, Ruth

eLife. 2018 Sep 27; 7:

Lehmann, Ruth

Science. 2018 Sep 07; 361(6406):974-975

Teixeira, Felipe Karam; Lehmann, Ruth

Cold Spring Harbor perspectives in biology. 2018 Aug 06;

Abrams, John M; Arkhipova, Irina R; Belfort, Marlene; Boeke, Jef D; Joan Curcio, M; Faulkner, Geoffrey J; Goodier, John L; Lehmann, Ruth; Levin, Henry L

Mobile DNA. 2018 Jun 22; 9:21-21

Coux, Rémi-Xavier; Teixeira, Felipe Karam; Lehmann, Ruth

Development. 2018 Apr 04; 145(7):

Teixeira, Felipe Karam; Okuniewska, Martyna; Malone, Colin D; Coux, Rémi-Xavier; Rio, Donald C; Lehmann, Ruth

Nature. 2017 Dec 14; 552(7684):268-272

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