We seek to elucidate the molecular basis of the immunological effector mechanisms of acquired malaria resistance in experimental animal models, individuals living in malaria endemic areas, and vaccinated human volunteers. We study both humoral and cellular protective mechanisms, including the relative role and mode of action of antibodies, cytotoxic T cells, and interferon and other cytokines on the distinct developmental stages of malarial parasites.
Most recently our research has been focused on a recombinant of the Yellow Fever vaccine expressing "foreign" microbial sequences.
This novel experimental approach has the advantage of requiring a single immunizing dose and eliciting a long lasting protection (> 4 months in mice).
Research Professor, Department of Pathology
Professor Emerita of Microbiology and Pathology, Department of Microbiology
MD from University of S?o Paulo
PhD from University of S?o Paulo
Journal of immunological methods. 2015 Dec; 427:42-50
Infection & immunity. 2014 Feb; 82(2):793-807
Journal of immunological methods. 2012 Mar 30; 377(1-2):47-52
Vaccine. 2011 Oct 06; 29(43):7335-7342
TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium
Memorias do Instituto Oswaldo Cruz. 2011 Aug; 106:167-171
Memorias do Instituto Oswaldo Cruz. 2011 Aug; 106 Suppl 1:167-171
Historia, ciencias, saude--Manguinhos. 2011 Jun 1; 18(2):559-564
THE MECHANISMS OF LATENCY OF MALARIA PARASITES IN THE MOSQUITO SALIVARY GLANDS [Meeting Abstract]
American journal of tropical medicine & hygiene. 2010 Nov; 83(5):111-111