Ruth S. Nussenzweig, MD, PhD

Research Professor, Department of Pathology

Professor Emerita of Microbiology and Pathology, Department of Microbiology

Keywords
development of experimental basis for malaria vaccine, immunoparasitology, mechanisms of protection
Summary

We seek to elucidate the molecular basis of the immunological effector mechanisms of acquired malaria resistance in experimental animal models, individuals living in malaria endemic areas, and vaccinated human volunteers. We study both humoral and cellular protective mechanisms, including the relative role and mode of action of antibodies, cytotoxic T cells, and interferon and other cytokines on the distinct developmental stages of malarial parasites.

Most recently our research has been focused on a recombinant of the Yellow Fever vaccine expressing "foreign" microbial sequences.

This novel experimental approach has the advantage of requiring a single immunizing dose and eliciting a long lasting protection (> 4 months in mice).

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Research Professor, Department of Pathology

Professor Emerita of Microbiology and Pathology, Department of Microbiology

PhD from University of S?o Paulo

MD from University of S?o Paulo

Huang, Jing; Li, Xiangming; Coelho-Dos-Reis, Jordana G A; Zhang, Min; Mitchell, Robert; Nogueira, Raquel Tayar; Tsao, Tiffany; Noe, Amy R; Ayala, Ramses; Sahi, Vincent; Gutierrez, Gabriel M; Nussenzweig, Victor; Wilson, James M; Nardin, Elizabeth H; Nussenzweig, Ruth S; Tsuji, Moriya

Journal of immunological methods. 2015 Dec; 427:42-50

Teixeira, Lais H; Tararam, Cibele A; Lasaro, Marcio O; Camacho, Ariane G A; Ersching, Jonatan; Leal, Monica T; Herrera, Socrates; Bruna-Romero, Oscar; Soares, Irene S; Nussenzweig, Ruth S; Ertl, Hildegund C J; Nussenzweig, Victor; Rodrigues, Mauricio M

Infection & immunity. 2014 Feb; 82(2):793-807

Mishra, Satish; Nussenzweig, Ruth S; Nussenzweig, Victor

Journal of immunological methods. 2012 Mar 30; 377(1-2):47-52

Mishra, Satish; Rai, Urvashi; Shiratsuchi, Takayuki; Li, Xiangming; Vanloubbeeck, Yannick; Cohen, Joe; Nussenzweig, Ruth S; Winzeler, Elizabeth A; Tsuji, Moriya; Nussenzweig, Victor

Vaccine. 2011 Oct 06; 29(43):7335-7342

Camacho, Ariane Guglielmi Ariza; Teixeira, Lais Helena; Bargieri, Daniel Youssef; Boscardin, Silvia Beatriz; Soares, Irene da Silva; Nussenzweig, Ruth Sonntag; Nussenzweig, Victor; Rodrigues, Mauricio Martins

Memorias do Instituto Oswaldo Cruz. 2011 Aug; 106 Suppl 1:167-171

Nussenzweig, Ruth Sonntag

Historia, ciencias, saude--Manguinhos. 2011 Jun 1; 18(2):559-564

THE MECHANISMS OF LATENCY OF MALARIA PARASITES IN THE MOSQUITO SALIVARY GLANDS [Meeting Abstract]

Zhang, Min; Fennell, Clare; Ranford-Cartwright, Lisa; Sakthivel, Ramanavelan; Gueirard, Pascale; Meister, Stephan; Caspi, Anat; Doerig, Christian; Nussenzweig, Ruth S; Tuteja, Renu; Sullivan, William J., Jr; Roos, David S; Menard, Robert; Fontoura, Beatriz M; Winzelers, Elizabeth A; Nussenzweig, Victor

American journal of tropical medicine & hygiene. 2010 Nov; 83(5):111-111

Zhang, Min; Fennell, Clare; Ranford-Cartwright, Lisa; Sakthivel, Ramanavelan; Gueirard, Pascale; Meister, Stephan; Caspi, Anat; Doerig, Christian; Nussenzweig, Ruth S; Tuteja, Renu; Sullivan, William J Jr; Roos, David S; Fontoura, Beatriz M A; Menard, Robert; Winzeler, Elizabeth A; Nussenzweig, Victor

Journal of experimental medicine. 2010 Jul 05; 207(7):1465-1474