Veronica M. Catanese, MD

Adjunct Associate Professor, Department of Medicine

Keywords
molecular regulation of post-mitotic tissue growth
Summary

The physiological stimuli of changing pressure and flow promote compensatory hypertrophy in several organ systems in humans and animals. Renal glomeruli in diabetes and left ventricular myocytes in hypertension display such post-mitotic tissue growth. While these result in initial adaptive benefits to the organism, fibrosis and loss of function of the organ eventually ensue, thereby leading directly to morbidity and mortality from these disease processes. Insulin-like growth factor I (IGF-I) is a peptide structurally and functionally very similar to insulin. IGF-I is less potent than insulin as a metabolic hormone but much more potent than insulin as a mitogenic agent. Unlike insulin, however, IGF-I protein is made in almost all organs, raising the possibility that it might function locally to control tissue growth. Our laboratory identified tissue-specific enhancement of IGF-I gene expression early in both these models of adaptive growth, suggesting that it participates in initiating the hypertrophic response in tissues no longer capable of cell division. We also identified differential regulation of a tissue-specific panel of IGF-binding proteins capable of restricting or promoting access of IGF-I to its receptor.

Current objectives are to: 1) identify the hormonal and physiological stimuli responsible for induction of the IGF-I growth factor axis in vivo and in vitro; 2) elucidate the mechanisms by which these factors regulate expression of the IGF-I and IGF binding protein genes; 3) define the structural and functional consequences of IGF-I overexpression in vivo and in vitro; and 4) determine if tissue-specific expression of IGF-I is necessary and/or sufficient to initiate hypertrophy. To achieve these aims, we combine physiological, molecular, and cell biological techniques and use both intact animal adenoviral expression systems and targeted cell culture for molecular analysis.

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Adjunct Associate Professor, Department of Medicine

MD from New York University

Smith, Lawrence G; Catanese, Veronica M

Annals of internal medicine. 2010 Jun 15; 152(12):818-819

Catanese, Veronica; Aronson, Paul

Virtual mentor : VM. 2005 Apr 1; 7(4):?-?

Kupersmith, Joel; Sung, Nancy; Genel, Myron; Slavkin, Harold; Califf, Robert; Bonow, Robert; Sherwood, Louis; Reame, Nancy; Catanese, Veronica; Baase, Catherine; Feussner, John; Dobs, Adrian; Tilson, Hugh; Reece, E Albert

Journal of investigative medicine. 2005 Mar; 53(2):67-72

Crowley, William F Jr; Sherwood, Louis; Salber, Patricia; Scheinberg, David; Slavkin, Hal; Tilson, Hugh; Reece, E Albert; Catanese, Veronica; Johnson, Stephen B; Dobs, Adrian; Genel, Myron; Korn, Allan; Reame, Nancy; Bonow, Robert; Grebb, Jack; Rimoin, David

JAMA. 2004 Mar 03; 291(9):1120-1126

Krackov, Sharon K; Levin, Richard I; Catanese, Veronica; Rey, Mariano; Aull, Felice; Blagev, Denitza; Dreyer, Benard; Grieco, Anthony J; Hebert, Cristy; Kalet, Adina; Lipkin, Mack Jr; Lowenstein, Jerome; Ofri, Danielle; Stevens, David

Academic medicine. 2003 Oct; 78(10):977-982

Sung, Nancy S; Crowley, William F Jr; Genel, Myron; Salber, Patricia; Sandy, Lewis; Sherwood, Louis M; Johnson, Stephen B; Catanese, Veronica; Tilson, Hugh; Getz, Kenneth; Larson, Elaine L; Scheinberg, David; Reece, E Albert; Slavkin, Harold; Dobs, Adrian; Grebb, Jack; Martinez, Rick A; Korn, Allan; Rimoin, David

JAMA. 2003 Mar 12; 289(10):1278-1287

Donohue TJ; Dworkin LD; Ma J; Lango MN; Catanese VM

Journal of investigative medicine. 1997 Dec; 45(9):584-591

Wang ZH; Ma J; Zeng BJ; Catanese VM; Samuels S; Gama Sosa MA; Kolodny EH

Neuroendocrinology. 1997 Sep; 66(3):203-211