Research Professor, Department of Pathology
Professor Emeritus of Pathology, Department of Pathology
Our lab is working on two major areas of research:the immunobiology of the pre-erythrocytic stages of malaria parasites and the development of a malaria vaccine. Minutes after mosquito bite, malaria sporozoites enter hepatocytes. Two membrane proteins of sporozoites named CS and TRAP are involved in the initial stages of infection. By gene targeting we are now creating parasite lines that bear subtle mutations in specific domains of CS and in TRAP to study the function of these molecules. We hope to use this information to increase the efficacy of existing CS-based vaccines.
Research Professor, Department of Pathology
Professor Emeritus of Pathology, Department of Pathology
MD from University of São Paulo
PhD from University of São Paulo
Cell host & microbe. 2017 Dec 13; 22(6):766-776.e4
PLoS pathogens. 2016 Jan; 12(1):e1005370
Journal of immunological methods. 2015 Dec; 427:42-50
Malaria journal. 2015 Aug 20; 14:324
Infection & immunity. 2014 Feb; 82(2):793-807
Eukaryotic cell. 2013 Feb; 12(2):161-7