Victor Nussenzweig, MD, PhD

Research Professor, Department of Pathology

Professor Emeritus of Pathology, Department of Pathology

immunobiology of intracellular protozoan parasites

Our lab is working on two major areas of research:the immunobiology of the pre-erythrocytic stages of malaria parasites and the development of a malaria vaccine. Minutes after mosquito bite, malaria sporozoites enter hepatocytes. Two membrane proteins of sporozoites named CS and TRAP are involved in the initial stages of infection. By gene targeting we are now creating parasite lines that bear subtle mutations in specific domains of CS and in TRAP to study the function of these molecules. We hope to use this information to increase the efficacy of existing CS-based vaccines.

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Research Professor, Department of Pathology

Professor Emeritus of Pathology, Department of Pathology

MD from University of S?o Paulo

PhD from University of S?o Paulo

Gimenez, Alba Marina; Lima, Luciana Chagas; Francoso, Katia Sanches; Denapoli, Priscila M A; Panatieri, Raquel; Bargieri, Daniel Y; Thiberge, Jean-Michel; Andolina, Chiara; Nosten, Francois; Renia, Laurent; Nussenzweig, Ruth S; Nussenzweig, Victor; Amino, Rogerio; Rodrigues, Mauricio M; Soares, Irene S

Frontiers in immunology. 2017; 8:1275-1275

Zhang, Min; Mishra, Satish; Sakthivel, Ramanavelan; Fontoura, Beatriz M A; Nussenzweig, Victor

PLoS pathogens. 2016 Jan; 12(1):e1005370-e1005370e1005370

Huang, Jing; Li, Xiangming; Coelho-Dos-Reis, Jordana G A; Zhang, Min; Mitchell, Robert; Nogueira, Raquel Tayar; Tsao, Tiffany; Noe, Amy R; Ayala, Ramses; Sahi, Vincent; Gutierrez, Gabriel M; Nussenzweig, Victor; Wilson, James M; Nardin, Elizabeth H; Nussenzweig, Ruth S; Tsuji, Moriya

Journal of immunological methods. 2015 Dec; 427:42-50

UIS2, a unique phosphatase required for the development of plasmodium liver stages [Meeting Abstract]

Zhang, M; Mishra, S; Nussenzweig, V

American journal of tropical medicine & hygiene. 2015 Oct; Conference:(64th):16

Nemetski, Sondra Maureen; Cardozo, Timothy J; Bosch, Gundula; Weltzer, Ryan; O'Malley, Kevin; Ejigiri, Ijeoma; Kumar, Kota Arun; Buscaglia, Carlos A; Nussenzweig, Victor; Sinnis, Photini; Levitskaya, Jelena; Bosch, Jurgen

Malaria journal. 2015 Aug 20; 14:324-324

Teixeira, Lais H; Tararam, Cibele A; Lasaro, Marcio O; Camacho, Ariane G A; Ersching, Jonatan; Leal, Monica T; Herrera, Socrates; Bruna-Romero, Oscar; Soares, Irene S; Nussenzweig, Ruth S; Ertl, Hildegund C J; Nussenzweig, Victor; Rodrigues, Mauricio M

Infection & immunity. 2014 Feb; 82(2):793-807

Zhang, Min; Joyce, Bradley R; Sullivan, William J Jr; Nussenzweig, Victor

Eukaryotic cell. 2013 Feb; 12(2):161-167

Goldberg, DE; Zhang, M; Nussenzweig, V

Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. p.123-130. (2567302)