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Wenbiao Gan, PhD

Skirball Institute

Professor, Department of Neuroscience and Physiology

Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine

Wenbiao Gan
Keywords
synaptic plasticity, imaging, metabolism, molecular, cellular, & translational neuroscience
Summary

Wen-Biao Gan, Ph.D. Skirball Institute and Department of Physiology and Neuroscience One of the most important features of the nervous system is its remarkable plasticity during development and in learning and memory. Many lines of evidence indicate that the number and distribution of synapses in many parts of the nervous system change throughout life. Very little is known at present about how changes in synaptic structure take place in living animals. We are studying the mechanisms that regulate structural plasticity of synapses by taking advantage of Green Fluorescent Protein (GFP) expressing transgenic mice in which synaptic structure are specifically labeled by GFP. Using a confocal microscope, we have recently been able to generate 3-dimensional reconstructions of synapses on individual neurons at the submandibular ganglion and the superior cervical ganglion of living mice. By following synapses of the same neuron over time, we have found that synaptic structure is generally stable over several days but undergoes substantial remodeling over a period of weeks in the mouse submandibular ganglion (Fig.1). The ability to follow individual inter-neuronal synapses in vivo opens a direct window to study many interesting questions such as: How dynamic are synapses once they are formed? How does neuronal activity modulate synaptic structure? How does change in synaptic structure occur as a function of age? We are currently addressing these questions using high-resolution in vivo confocal imaging, electron microscopy and molecular approaches. In addition to study neural plasticity in the peripheral nervous system, we have recently developed a technique for rapid labeling of a large number of neurons with many different colors (Fig.2). Using this technique, we are planning to study structural plasticity of neuronal circuits in the central nervous system.

Phone

212-263-2585

Academic office

540-562 First Avenue

Fifth Floor

New York, NY 10016

Lab Website
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Professor, Department of Neuroscience and Physiology

Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine

PhD from Columbia University

Lai, Baoling; Li, Miao; Hu, Wanling; Li, Wei; Gan, Wen-Biao

Developmental neurobiology. 2018 Sep 20; 78(9):859-872

Lai, Cora Sau Wan; Adler, Avital; Gan, Wen-Biao

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2018 Sep 11; 115(37):9306-9311

Learning and sleep-dependent dendritic spine plasticity and maintenance [Meeting Abstract] . Opens in a new tab

Gan, W

Journal of sleep research. 2018 September; Conference:(24th):64

Zhao, Ruohe; Zhou, Hang; Huang, Lianyan; Xie, Zhongcong; Wang, Jing; Gan, Wen-Biao; Yang, Guang

Frontiers in cellular neuroscience. 2018 Apr 20; 12:107-107

Bai, Yang; Li, Miao; Zhou, Yanmei; Ma, Lei; Qiao, Qian; Hu, Wanling; Li, Wei; Wills, Zachary Patrick; Gan, Wen-Biao

Molecular neurodegeneration. 2017 Nov 14; 12(1):86-86

Zhou, Yanmei; Lai, Baoling; Gan, Wen-Biao

Scientific reports. 2017 Jul 10; 7(1):4977-4977

Cichon, Joseph; Blanck, Thomas J J; Gan, Wen-Biao; Yang, Guang

Nature neuroscience. 2017 Jun 26; 20(8):1122-1132

Zhao, Ruohe; Hu, Wanling; Tsai, Julia; Li, Wei; Gan, Wen-Biao

Molecular neurodegeneration. 2017 Jun 12; 12(1):47-47