William M. Manger, MD, PhD

Clinical Professor, Department of Rehabilitation Medicine

renal hemodynamics, urinary cGMP excretion

Previously, we showed that Dahl salt-sensitive (DS) rats increase renal vascular resistance (RVR) in response to a feeding of excessive salt (8% NaCl) before total peripheral resistance increases and before hypertension occurs. Failure of renal vasculature to dilate, as normally occurs in salt-resistant (DR) rats fed a high salt diet, may play an etiologic role in developing hypertension in DS rats. We also showed that renal vasculature in DS rats is hyperreactive to vasoconstrictors (angiotensin II and norepinephrine) and hyporeactive to vasodilators (ANP and nitroprusside). ANP, via stimulation of cell-bound receptors and nitroprusside (NP), directly via nitric oxide (NO) generation, cause renal vasodilation by generating guanosine 3'5'-cyclic monophosphate (cGMP). To determine if defective renal vasodilation in DS rats is due to impaired production of cGMP, we examined the influence of NP infusion and salt intake on RVR and cGMP excretion in DS and DR rats. Our results demonstrated that salt feeding and NP infusion increase cGMP excretion and decrease RVR in DR rats (P<0.01), and, although this relationship was less clear in DS rats, a reciprocal relationship was indicated between RVR and cGMP excretion in all animals studied. A relatively small increase in cGMP was associated with maximal renal vasodilation. Salt feeding and NP infusion caused less increase in cGMP excretion in DS than in DR rats (P<0.01). These studies support the concept that impairment in cGMP generation may play a primary role in the kidneys' inability in DS rats to vasodilate in response to increased salt intake. Such an impairment could contribute to salt retention and development of hypertension.

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Clinical Professor, Department of Rehabilitation Medicine

PhD from University of Minnesota

MD from Columbia University

Manger, William M; Manger, Lynn S; Minno, Alexander M; Killmeyer, Mike; Holzman, Robert S; Schullinger, John N; Roccella, Edward J

Journal of school health. 2012 Oct; 82(10):462-468

Manger, William M; Simchon, Shlomoh; Stokes, Michael B; Reidy, Jason J; Kumar, Asok R; Baer, Leslie; Gallo, Gloria; Haddy, Francis J

Journal of hypertension. 2009 Mar; 27(3):587-598

'Cerebral vasculitis': Mistaken cause of fluctuating blood pressure and neurological manifestations

Manger, WM

Kidney international. 2008 Feb; 73(3):354-359

Eisenhofer, Graeme; Rivers, Graham; Rosas, Alejandro L; Quezado, Zena; Manger, William M; Pacak, Karel

Drug safety. 2007; 30(11):1031-1062

Diagnosis and management of pheochromocytoma - recent advances and current concepts [Meeting Abstract]

Manger, WM

Kidney international. 2006 Dec; 70(12):S30-S35

Manger, William M

Annals of the New York Academy of Sciences. 2006 Aug; 1073:1-20

Effect of dietary NaCl on blood pressure (BP) response to intraventricular (ICV) infusion of NaCl in Dahl rats: Role of blood-brain barrier [BBB) and cGMP [Meeting Abstract]

Simchon, S; Golanov, E; Manger, WM

Hypertension. 2005 Nov; 46(5):834-834

Manger, William M

American journal of hypertension. 2005 Oct; 18(10):1266-1270