About Us

Maintenance of genome integrity relies upon cellular systems that monitor and repair DNA damage. DNA double strand breaks occur during normal physiological reactions including DNA replication, antigen receptor rearrangements in lymphocytes, and meiotic recombination in germ cells. Understanding the mechanisms by which cells detect, signal, and repair DNA damage will provide insight into cancer etiology and elucidate targets for therapeutic intervention. Epigenetic mechanisms (including DNA methylation and histone modification) play a fundamental role in chromosome stability, genome propagation, and gene expression, which impact human development and underlie human disease syndromes like Angelman and Fragile X. Effective maintenance and interpretation of the genome is essential for normal cell division, tissue homeostasis, and cellular and organismal fitness. Understanding the fundamental mechanisms controlling genome integrity will provide insights in human genome function and lead to effective treatments for inherited human diseases and cancer.

The goal of the Genome Integrity graduate program is to equip students for modern research in genome integrity and its application to human disease. We aim to provide an intellectually diverse and rigorous research environment that emphasizes the basic principles of genome organization and function. Students will have the opportunity to work with a variety of genetic systems