PI: Joel S. Schuman
Aim: To investigate the clinical problems associated with the detection and monitoring of glaucomatous changes in retinal structure and function, and to investigate new diagnostics for glaucoma including optical coherence tomography (OCT), multifocal electroretinography, and optic nerve head assessment.
PI: Gadi Wollstein and Ian Sigal
Aim: To assess the effects of modulating the intraocular and cerebral spinal fluid pressures on the optic nerve head in a primate model.
Aim: To develop a new non-human primate animal model (marmoset) that will be useful in better understanding glaucoma.
PI: James G. Fujimoto
Aim: To develop new high-speed ultrahigh resolution optical coherence tomography (OCT) technology for imaging retinal structure and to perform clinical studies of retinal disease and glaucoma.
PI: Joshua D. Stein
Aim: To identify and predict glaucomatous disease progression using advanced analysis tools.
NIH R01-EY022305Title: NEIGHBOORHOOD Consortium for POAG Genomics
PI: Janey L. Wiggs
Aim: To identify genes associated with the development of glaucoma.
PI: George Stetten
Aim: To develop a new device to display optical coherence tomography (OCT) images under a stereo surgical microscope for guidance in microsurgical procedures by means of an in-situ virtual image that floats within the target tissue at its actual location.
PI: Kevin Chan
Aim: To develop novel structural and physiological magnetic resonance imaging (MRI) techniques for whole-brain, non-invasive, and longitudinal measurements of damage and disease progression along the visual pathway in glaucoma patients in order to combine neuroimaging and neuroprotective approaches to guide vision preservation and restoration in humans and experimental animal models.
Completed Research Support
Glaucoma Research FoundationTitle: Measuring the In-vivo Effects on the Optic Nerve Head of Acute Variations in Cerebrospinal Fluid Pressure.
PI: Matthew Smith
Aim: To identify the effect of cerebral spinal fluid pressure modulation on optic nerve head morphology.
Research to Prevent Blindness (New York, NY)Medical Student Fellowship (Awardee: Zachary Dong; Mentor: Gadi Wollstein)
NMSS RG-4649A5Title: Mechanisms of Retinal Neurodegeneration and Visual Pathway Axonal Loss in MS
PI: Laura Balcer
Aim: To define the structure-function relationships in the anterior visual pathway of patients with multiple sclerosis (MS) with respect to the timing of neuronal vs. axonal loss in vivo by spectral domain OCT, and to determine the relative importance of each process to vision loss, neurologic function, and quality of life.
CDRMP-MR130411Title: Improving Viability and Functional Outcome after Whole Eye Transplantation
PI: Kia Washington
Aim: To establish the baseline anatomical considerations necessary to perform whole eye transplantation in the swine model, and to evaluate the transplant’s viability and structural integrity.
NIH R21-EY019092Title: Nanoparticle Contrast Enhancement for Optical Coherence Tomography Pilot Study
PI: Gadi Wollstein
Aim: To design particles that could attach to specific layers in the retina, and through changes in optical properties enhance the appearance and contrast of retinal layers as seen with optical coherence tomography (OCT) in vivo.
NIH R01-EY013516Title: Advanced Imaging for Glaucoma Diagnosis
PI: David Huang
Aim: The goal of this partnership was to develop advanced imaging technologies to improve the detection and management of glaucoma. The advanced imaging technologies included optical coherence tomography (OCT), scanning laser polarimetry (SLP), and scanning laser tomography (SLT), which were evaluated in a longitudinal 5-year clinical trial composed of glaucoma suspects, glaucoma patients, and normal subjects.
NIH R44-EY018986Title: High Performance Multimodal Adaptive Optics Retinal Imaging
PI: R. Daniel Ferguson
Aim: The assessment of the clinical utility of high performance multimodal adaptive optics optical coherence tomography (AO-OCT) and scanning laser ophthalmoscopy (SLO).
UL1 RR024153-RAND - University of Pittsburgh Health Institute, NCRR, NIHTitle: Evaluating Glaucoma Diagnostic Skills of Non-Glaucoma Experts Using Optic Disc Photographs, Visual Fields and Optic Imaging Devices
PI: Gadi Wollstein
Aim: To test the influence of training and knowledge of visual fields and glaucoma imaging device data on the glaucoma diagnostic ability of non-glaucoma expert eye care professionals (optometrists, trainees in ophthalmology, and general ophthalmologists) in comparison with glaucoma experts.
National Glaucoma Research - American Health Assistance FoundationTitle: Spectral OCT Doppler Assessment of Aqueous Outflow
PI: Joel S. Schuman
Aim: To determine the precision and accuracy of spectral domain optical coherence tomography (SD-OCT) imaging technique’s non-invasive visualization and quantification of aqueous outflow by the comparison of SD-OCT structural measurements with gold standard histology, using a human cadaver eye model with known controlled flow rates.