Financial Support

    Ongoing Research Support

  • NIH R01-EY013178

    Title: Novel Glaucoma Diagnostics for Structure and Function
    PI: Joel S. Schuman
    Aim: To investigate the clinical problems associated with the detection and monitoring of glaucomatous changes in retinal structure and function, and to investigate new diagnostics for glaucoma including optical coherence tomography (OCT), multifocal electroretinography, and optic nerve head assessment.

  • NIH R01-EY025011

    Title: Interplay between Intraocular and Cerebral Spinal Fluid Pressure Effects on the Optic Nerve Head in vivo
    PI: Gadi Wollstein and Ian Sigal
    Aim: To assess the effects of modulating the intraocular and cerebral spinal fluid pressures on the optic nerve head in a primate model.

  • BrightFocus Foundation Grant

    PI: Gadi Wollstein and John Danias
    Aim: To develop a new non-human primate animal model (marmoset) that will be useful in better understanding glaucoma.


  • NIH R01-EY011289

    Title: Novel Diagnostics with Optical Coherence Tomography
    PI: James G. Fujimoto
    Aim: To develop new high-speed ultrahigh resolution optical coherence tomography (OCT) technology for imaging retinal structure and to perform clinical studies of retinal disease and glaucoma.

  • NIH R01-EY026641

    Title: Personalized Forecasting of Disease Trajectory for Patients with Open Angle Glaucoma
    PI: Joshua D. Stein
    Aim: To identify and predict glaucomatous disease progression using advanced analysis tools.

  • NIH R01-EY022305

    Title: NEIGHBOORHOOD Consortium for POAG Genomics
    PI: Janey L. Wiggs
    Aim: To identify genes associated with the development of glaucoma.

  • NIH R01-EY021641

    Title: Microsurgical In-Situ Image Guidance with Optical Coherence Tomography
    PI: George Stetten
    Aim: To develop a new device to display optical coherence tomography (OCT) images under a stereo surgical microscope for guidance in microsurgical procedures by means of an in-situ virtual image that floats within the target tissue at its actual location.

  • NIH R01-EY028125

    Title: Glaucoma Neuroimaging in Humans and Experimental Animal Models
    PI: Kevin Chan
    Aim: To develop novel structural and physiological magnetic resonance imaging (MRI) techniques for whole-brain, non-invasive, and longitudinal measurements of damage and disease progression along the visual pathway in glaucoma patients in order to combine neuroimaging and neuroprotective approaches to guide vision preservation and restoration in humans and experimental animal models.

    Completed Research Support

  • Glaucoma Research Foundation

    Title: Measuring the In-vivo Effects on the Optic Nerve Head of Acute Variations in Cerebrospinal Fluid Pressure.
    PI: Matthew Smith
    Aim: To identify the effect of cerebral spinal fluid pressure modulation on optic nerve head morphology.

  • Research to Prevent Blindness (New York, NY)

    Medical Student Fellowship (Awardee: Zachary Dong; Mentor: Gadi Wollstein)

  • NMSS RG-4649A5

    Title: Mechanisms of Retinal Neurodegeneration and Visual Pathway Axonal Loss in MS
    PI: Laura Balcer
    Aim: To define the structure-function relationships in the anterior visual pathway of patients with multiple sclerosis (MS) with respect to the timing of neuronal vs. axonal loss in vivo by spectral domain OCT, and to determine the relative importance of each process to vision loss, neurologic function, and quality of life.

  • CDRMP-MR130411

    Title: Improving Viability and Functional Outcome after Whole Eye Transplantation
    PI: Kia Washington
    Aim: To establish the baseline anatomical considerations necessary to perform whole eye transplantation in the swine model, and to evaluate the transplant’s viability and structural integrity.

  • NIH R21-EY019092

    Title: Nanoparticle Contrast Enhancement for Optical Coherence Tomography Pilot Study
    PI: Gadi Wollstein
    Aim: To design particles that could attach to specific layers in the retina, and through changes in optical properties enhance the appearance and contrast of retinal layers as seen with optical coherence tomography (OCT) in vivo.

  • NIH R01-EY013516

    Title: Advanced Imaging for Glaucoma Diagnosis
    PI: David Huang
    Aim: The goal of this partnership was to develop advanced imaging technologies to improve the detection and management of glaucoma. The advanced imaging technologies included optical coherence tomography (OCT), scanning laser polarimetry (SLP), and scanning laser tomography (SLT), which were evaluated in a longitudinal 5-year clinical trial composed of glaucoma suspects, glaucoma patients, and normal subjects.

  • NIH R44-EY018986

    Title: High Performance Multimodal Adaptive Optics Retinal Imaging
    PI: R. Daniel Ferguson
    Aim: The assessment of the clinical utility of high performance multimodal adaptive optics optical coherence tomography (AO-OCT) and scanning laser ophthalmoscopy (SLO).

  • UL1 RR024153-RAND - University of Pittsburgh Health Institute, NCRR, NIH

    Title: Evaluating Glaucoma Diagnostic Skills of Non-Glaucoma Experts Using Optic Disc Photographs, Visual Fields and Optic Imaging Devices
    PI: Gadi Wollstein
    Aim: To test the influence of training and knowledge of visual fields and glaucoma imaging device data on the glaucoma diagnostic ability of non-glaucoma expert eye care professionals (optometrists, trainees in ophthalmology, and general ophthalmologists) in comparison with glaucoma experts.

  • National Glaucoma Research - American Health Assistance Foundation

    Title: Spectral OCT Doppler Assessment of Aqueous Outflow
    PI: Joel S. Schuman
    Aim: To determine the precision and accuracy of spectral domain optical coherence tomography (SD-OCT) imaging technique’s non-invasive visualization and quantification of aqueous outflow by the comparison of SD-OCT structural measurements with gold standard histology, using a human cadaver eye model with known controlled flow rates.

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