Publications List

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Aykut B, Usyk M, Torres LE, Werba G, Zhang K, GuoY, Li Q, Akkad N, Lall S, Wadowski B, Gutierrez J, Kochen Rossi JA, Herzog JW, Diskin B, Torres-Hernandez A, Leinwand J, Wang W, TaUnk PS, Savadkar S, Kanal M, Saxena A, Li X, Cohen D, Sartor RB, Saxena D, Miller G. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Supression. Cancer Discovery. 2018; 8(4); 1-14.
[PMID: 29567829]

Daley D, Mani V, Mohan N, Akkad N, Ochi A, Heindel D, Lee K B, Zambrinis C, Balasumbramania Pandian G SD, Savadkar S, Torres-Hernandez A, Nayak S, Wang D, Hundeyin M, Diskin B, Werba G, Barilla R, Chang S, Gardner L, Mahal L K, Ueberheide B, Miller G. Dectin 1 Activation on Macrophages by Galectin 9 Promotes Pancreatic Carcinoma and Peritumoral Immune Tolerance. Nature Medicine. 2017; 23; 556-567.
[PMID: 283943331]

Daley D, Mani V, Mohan N, Akkad N, Gautam S.D., Balasubramania P, Savadkar S, Lee K B, Torres-Hernandez A, Aykut B, Diskin B, Wang W, Farooq M.S., Mahmud A. I, Werba G, Morales E, Lall S, Wadowski B, Rubin A, Berman M, Narayanan R, Hundeyin M, Miller G. NLRP3 Signaling Drives Macrophage-Induced Adaptive Immune Suppression in Pancreatic Carcinoma. Journal of Experimental Medicine. 2017; 214 (6): 1711-1724.
[PMID: 28442553]

Jang JE, Hajdu CH, Liot C, Miller G, Dustin ML, Bar-Sagi D. Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negatives Anti-tumor Immunity in Pancreatic Cancer. Cell Reports. 2017; 20(3): 558 - 571.
[PMID: 28723561]

Daley D, Zambirinis C, Seifert L, Akkad N, Mohan N, Werba G, Barilla R, Torres-Hernandez A, Hundeyin M, Mani V, Avanzi A, Tippens D, Narayanan R, Jang J, Newman E, Pillarisetty V, Dustin M, Bar-Sagi D, Hajdu C, Miller G. γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation. Cell. 2016; 166(6): 1485-1499.
[PMID: 27569912]

Seifert L, Werba G, Tiwari S, Ly NNG, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G. The Necrosome Promotes Pancreas Oncogenesis via CXCL1 and Mincle Induced Immune Suppression. Nature. 2016; 14;532(7598):245-9.
[PMID: 27049944]

Greco S, Torres-Hernandez A, Kalabin A, Whitman C, Rokosh R, Ravirala S, Ochi A, Gutierrez J, Salyana M, Mani V, Nagaraj S, Deutsch M, Seifert L, Daley D, Barilla R, Hundeyin M, Nikifrov Y, Tejada K, Gelb BE, Katz SC, Miller G.Mincle Signaling Promotes Con A Hepatitis. Journal of Immunology. 2016;197 (7) 2816-2827. [Epub ahead of print].
[PMID: 27559045]

Seifert L, Werba G, Tiwari S, Ly NNG, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G. Radiation Therapy Induces Macrophages to Suppress Immune Responses Against Pancreatic Tumors in Mice. Gastroenterology. 2016; 150(7):1659-1672.
[PMID: 26946344]

Greco SH, Mahmood SK, Vahle AK, Ochi A, Batel J, Deutsch M, Barilla R, Seifert L, Pachter HL, Daley D, Torres-Hernandez A, Hundeyin M, Mani VR, Miller G. Mincle suppresses Toll-like receptor 4 activation. Journal of Leukocyte Biology. 2016;100(1):185-94.
[PMID: 26747838]

Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, Seifert L, Daley D, Greco S, Deutsch M, Jonnadula S, Torres-Hernandez A, Tippens D, Pushalkar S, Eisenthal A, Saxena D, Ahn J, Hajdu C, Engle DD, Tuveson D, Miller G. TLR9 Ligation in Pancreatic Stellate Cells Promotes Tumorigenesis. Journal of Experimental Medicine. 2015; 212(12):2077-94.
[PMID: 26481685]
Seifert L, Deutsch M, Alothman S, Alqunaibit D, Werba G, Pansari M, Pergamo M, Ochi A, Torres-Hernandez A, Levie E, Tippens D, Greco S, Tiwari S, Giao Ly NN, Eisenthal A, Van Heerden E, Avanzi A, Barilla R, Zambirinis CP, Rendon M, Daley D, Pachter HL, Hajdu C, Miller G. Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways. Cell Reports. 2015; 13(9):1909-21.
[PMID: 26655905]

Greco SH, Tomkötter L, Vahle A, Rokosh R, Avanzi A, Mahmood SK, Deutsch M, Alothman A, Alqunaibit D, Ochi A, Zambirinis CP, Mohaimin T, Rendon M, Levie E, Pansari M, Torres-Hernandez A, Daley D, Barilla R, Pachter HL, Tippens D, Malik H, Boutajangout A, Wisniewski T, Miller G. TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia. Plos One. 2015; 10(7):e0132786. doi: 10.137/journal.pone.0132786.
[PMID: 26172047]

Deutsch M, Graffeo CS, Rokosh R, Pansari M, Ochi A, Levie EM, Tippens DM, Greco S, Barilla R, Tomkötter L, Zambirinis CP, Avanzi N, Gulati R, Pachter HL, Torres-Hernandez A, Daley D, Miller G. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death and Disease. 2015; 6e1759. doi: 10.1038/cddis.2015.126.
[PMID: 25950489]

Kamphorst JJ, Nofal M, Commisso C, Hackett S, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 2015; 75(3):544-53.
[PMID: 25644265]

Rao R, Graffeo CS, Gulati R, Jamal M, Narayan S, Zambirinis C, Barilla R, Deutsch M, Greco S, Ochi A, Tomkötter L, Blobstein R, Avanzi A, Tippens DM, Gelbstein Y, Van Heerden E, Miller G. Interleukin 17-producing γδT cells promote hepatic regeneration in mice. Gastroenterology. 2014; 147(2):473-484.
[PMID: 24801349]

Ramkhelawon B, Hennessy EJ, Ménager M, Sheedy FJ, Ray TD, Wanschel A, Babunovi S, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Littman DR, Rayner KJ, Moore KJ. Netrin-1 promotes macrophage accumulation and insulin resistance in obesity. Nature Medicine. 2014; 20(4):377-84.
[PMID: 24584118]

Rielland M, Cantor DJ, Graveline R, Hajdu C, Mara L, Diaz B, Miller G, David G. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression Journal of Clinical Investigation. 2014; 124(5):2125-35.
[PMID: 24691445]

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach E, Bergo M, Philips M. Icmt Deficiency Exacerbates a K-Ras-driven Mouse Model of Pancreatic Neoplasia by Suppressing Notch Signaling. Journal of Clinical Investigation. 2013;123(11):4681–4694.

Rehman A, Hemmert KC, Ochi A, Jamal M, Henning JR, Barilla RM, Quesada JP, Zambirinis CP, Tang K, Ego-Osuala MO, Rao RS, Greco S, Deutsch M, Narayan S, Pachter HL, Graffeo CS, Miller G. Role of Fatty-acid Synthesis in Dendritic Cell Generation and Function. Journal of Immunology. 2013: 190(9):4640-9.
[PMID:  23536633]

Henning JR, Graffeo CS , Zambirinis CP, Rehman A, Hackman M, Fallon N, Barilla RM, Jamal M, Deutsch M, Greco S, Bin-Saeed U, Rao RS, Ego-Osuala M, Bader S, Quesada JP, Acehan, Miller G. Dendritic Cells Limit Fibro-Inflammatory Injury in nonalcoholic steatohepatitis in mice. Hepatology. 2013 58(2):589-602.
[PMID: 23322710]

Ochi A, Graffeo CS, Zambirinis CP, Ego-Osuala M, Rehman A, Hackman M, Fallon NC, Henning JR, Barilla RM, Jamal M, Rao R, Greco S, Deutsch M, Bin Saeed U, Hajdu CH, Miller G. Toll-Like Receptor 7 Regulates Pancreatic Carcinogenesis in Mice and Humans. Journal of Clinical Investigation. 2012; 122(11):4118-4129.
[PMID: 23023703]

Ochi A, Nguyen AH, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, Zambirinis CP, Fallon NC, Rehman A, Pylayeva-Gupta Y, Bader S, Hajdu CH, Frey AB, Bar-Sagi D, Miller G. MyD88 inhibition augments dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. Journal of Experimental Medicine.2012; 209(9):1671-87.
[PMID: 22908323]

Ibrahim J, Nguyen AH, Rehman A, Ochi A, Jamal M, Graffeo CS, Henning JR, Zambirinis CP, Fallon N, Barilla R, Badar S, Mitchell A, Rao R, Acehan D, Frey AB, Miller G. Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver. Gastroenterology. 2012; 143(4)1061-72.
[PMID: 22705178]

Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.Cancer Cell. 2012; 21(6):836-47.
[PMID: 22698407]

Mallen-St Clair J, Soydaner-Azeloglu R, Lee KE, Taylor L, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D. EZH2 couples pancreatic regeneration to neoplastic progression. Genes & Development. 2012;26(5):439-44..
[PMID: 22391448]

Connolly MK, Ayo D, Malhotra A, Hackman M, Bedrosian AS, Ibrahim J, Cieza-Rubio NE, Nguyen AH, Henning JR, Dorvil-Castro M, Pachter HL, Miller G. Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. Hepatology. 2011;54(3):959-68.
[PMID: 21574173]

Bedrosian AS, Nguyen AH, Hackman M, Connolly MK, Malhotra A, Ibrahim J, Cieza-Rubio NE, Henning JR, Barilla R, Rehman A, Pachter HL, Medina-Zea MV, Cohen SM, Frey AB, Acehan D, Miller G. Dendritic cells promote pancreatic viability in mice with acute pancreatitis. Gastroenterology. 2011;141(5):1915-26 e1-14.
[PMID: 21801698]

Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. Journal of Leukocyte Biology. 2010;87(4):713-25.
[PMID: 20042467]

Connolly MK, Bedrosian AS, Malhotra A, Henning JR, Ibrahim J, Vera V, Cieza-Rubio NE, Hassan BU, Pachter HL, Cohen S, Frey AB, Miller G. In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. Journal of Immunology. 2010;185(4):2200-8.
[PMID: 20639479]

Connolly MK, Bedrosian AS, Mallen-St Clair J, Mitchell AP, Ibrahim J, Stroud A, Pachter HL, Bar-Sagi D, Frey AB, Miller G. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. Journal of Clinical Investigation. 2009;119(11):3213-25.
[PMID: 19855130]

Editorials and Reviews

Zambrinis C, Miller G. Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer. Trends in Molecular Medicine. 2017; 23 (5); 465-481.
[PMID: 28400243 ]

Daley D, Miller G. The Role of Gamma Delta T cells in Pancreatic Cancer: what could this mean for the clinic? Expert Review of Gastroenterology and Hematology. 2017; 11(7); 609-610. .
[PMID: 28345379]

Torres-Hernandez A, Miller G. TIMPing Fate: Why Pancreatic Cancer Cells Sojourn in the Liver. Gastroenterology. 2016; 151(5):807-808.
[PMID: 27702557].

Seifert L, Miller G. Molecular Pathways: The Necrosome - A Target for Cancer Therapy. Clinical Cancer Research. 2016; 23(5); 1132-1136.
[PMID: 27932417]

Pergamo M, Miller G. Myeloid Derived Suppressor Cells and their Role in Pancreatic Cancer. Cancer Gene Therapy. 2017; 24, 100-105.
[PMID: 27910857]

Werber G, Seifert L, Miller G. Necropoptoic Cell Death - An Unexpected Driver of Pancreatic Oncogenesis. Cell Cycle. 2016. 15 (16), 2095-2096.
[PMID: 27245149]

Caso R, Miller G. Role of tumor associated macrophages in regulating pancreatic cancer progression
World Journal of Immunology. 2016. 6(1): 9-18.
[Full text]

Zambirinis CP, Pushalkar S, Saxena D, Miller G. Pancreatic Cancer, Inflammation and Microbiome. Cancer Journal. 2014. 20(3):195-202.
[PMID: 24855007]

Zambirinis CP, Ochi A, Barilla R, Greco S, Deutsch M, Miller G. Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer. Cell Cycle. 2013;12(8):1153-4.
[PMID: 23549168]

Zambirinis CP, Miller G. Signaling via MYD88 in the pancreatic tumor microenvironment: A double-edged sword. Oncoimmunology. 2013 Jan 1;2(1):e22567.
[PMID: 23483804]