Juan Francisco Aranda Gomez, PhD, Associate Research Scientist

Juan Francisco Aranda GomezI obtained my degree in Biochemistry from the Universidad de Granada and I received my PhD in Molecular Biology at the Universidad Autonoma de Madrid in Spain. My PhD project focused primarily on the functional characterization of novel “raft-associated” protein machinery involved in cell migration and inflammation.

I began my postdoctoral career in the United States, where I was involved in several projects characterizing the role of microRNAs in lipid metabolism and LDL-receptor mediated endocytosis.

I recently joined the Diabetes Research Program at NYU as an Associate Research Scientist. My current research projects include the elucidation of signaling events upon RAGE-mDIA1 interaction.

1. Sala F, Aranda JF, Rotllán N, Ramirez CM, Elia L, Condorelli G, Catapano AL, Fernández-Hernando C, Norata GD. MiR-143/145 deficiency protects from atherosclerosis: effect on ATP-binding cassette A1 expression. Thrombosis & Haemostasis 2014 Jul 10;112(4)
2.  Goedeke L, Aranda JF, Fernández-Hernando C. miRNA regulation of lipoprotein metabolism. Curr Opin Lipidol 2014 Aug;25(4):282-8
3.   Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C. Akt signalling in epidermis leads to stem cell activation and promotes tumour development. Stem Cell 2014 Jul; 32(7):1917-28.
4.   Aranda JF, Madrigal-Matute J. Rotllán N and Fernandez-Hernando C. MicroRNA modulation of lipid metabolism and oxidative stress in cardiometabolic diseases. Free Radical Biology and Medicine 2013 Sep; 64:31-9.
5.   Ramírez CM, Rotllan N, Vlassov AV, Davalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel AC, Zavadil J, Castrillo A, Jungsu K, Suárez Y, Fernandez-Hernando C. Control of Cholesterol Metabolism and Plasma HDL Levels by miRNA-144. Circ Res. 2013 Jun 7; 112(12):1592-601
6.  Madrigal-Matute J, Rotllan N, Aranda JF, Fernández-Hernando C. MicroRNAs and atherosclerosis. Curr Atheroscler Rep. 2013 May; 15 (5):322.
7.   Aranda JF, Reglero-Real N, Marcos-Ramiro B, Ruiz-Sáenz A, Fernández-Martín L, Bernabé M, Kremer L, Correas I, Ridley AJ, Alonso MA, Millán J. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Mol Biol Cell. 2013 Feb; 24(4):483-94.
8.   Dueñas M, Santos M, Aranda JF, Bielza I, Martínez-Cruz AB, Lorz C, Taron M, Ciruelos EM, Rodríguez-Peralto JL, Martín M, Larrañaga P, Rosell R, Paramio JM and García-Escudero R. Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes. PLoS One. 2012; 7(8):e42494.
9.   Aranda JF, Reglero-Real N, Kremer L, Marcos-Ramiro B, Ruiz-Saenz A, Calvo M, Enrich C, Correas I Millán J and Alonso MA. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. Mol Biol Cell. 2011 Apr; 22(8):1252-1262.
10.  Madrid R, Aranda JF, Rodríguez-Fraticelli AE, Ventimiglia L, Andrés-Delgado L, Shehata M, Fanayan S, Shahheydari H, Gómez S, Jiménez A, Martín-Belmonte F, Byrne JA and Alonso MA. The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation with Cdc42 and MAL2. Dev Cell. 2010 May 18; 18(5):814-27.
 Editorial; Breitsprecher D1, Faix J. The inverted Formin INF2 sorts it out. Dev Cell. 2010 May 18; 18(5):689-90.

11.  Bello-Morales R, De Marco MC, Aranda JF, Matesanz F, Alcina A and López-Guerrero JL. Characterization of the MAL2 positive compartment in oligodendrocytes. Exp Cell Res. 2009 Nov 15; 315(19):3453-65.
12.  Goldstein Magal L, Yaffe Y, Shepshelovich J, Aranda JF, de Marco MD, Gaus K, Alonso MA, Hirschberg K. Clustering and Lateral Concentration of Raft Lipids by the MAL Protein. Mol Biol Cell. 2009 Aug; 20(16):3751-62.
13.  Yu MJ, Pisitkun T, Wang G, Aranda JF, Gonzales PA, Tchapyjnikov D, Shen RF, Alonso MA, Knepper MA. Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C661-78.
14.   Suárez Y, González-Santiago L, Zarich N, Dávalos A, Aranda JF, Alonso MA, Lasunción MA, Rojas JM and Muñoz A. Aplidin cellular binding and Rac1/JNK pathway activation depend on membrane cholesterol content. Mol. Pharmacol. 2006 Nov;70(5):1654-63
15.  Marazuela M, Martín-Belmonte F, García-López MA, Aranda JF, de Marco MC and Alonso MA Expression and distribution of MAL2, an essential component of the machinery for basolateral to-apical transcytosis, in human thyroid epithelial cells. Endocrinology 2004 145, 1011-1016.
16.  Martín-Belmonte F, Martínez-Menárguez JA, Aranda JF, Ballesta J, de Marco MC and Alonso MA. MAL regulates clathrin-mediated endocytosis at the apical surface of Madin-Darby canine kidney cells. J. Cell Biol. 2003, 163, 155-164.