Weiser Lab - Microbiology

Jeffrey N. Weiser, M.D.
Jan T. Vilcek Professor of Molecular Pathogenesis
Chair, Department of Microbiology
550 First Avenue
Medical Science Building, Rm. 256
New York, NY 10016
Tel: (212) 263-1080
Email: Jeffrey.Weiser@nyumc.org

 

 

Education:

B.S. (Biological Sciences) Stanford University, 1979.
M.D. Harvard University, 1984.
Resident in Pediatrics, University of Washington, 1984-87
Research Fellow, Oxford University, 1987-89
Research Associate, Rockefeller University, 1989-92

Faculty appointments:

Professor of Microbiology and Pediatrics, University of Pennsylvania School of Medicine (through 12/31/14)
Jan T. Vilcek Professor of Molecular Pathogenesis, New York University School School of Medicine (2015 - )

Description of Weiser Lab Research:

The Weiser lab investigates the molecular basis of host-pathogen interaction for agents that reside in and infect the human respiratory tract. Most studies focus on the pathogenesis of Streptococcus pneumoniae because of its prominence as a cause of acute respiratory tract infection. Other pathogens under investigation in the laboratory have included Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus aureus, and Influenza A. Many projects focus on colonization of the mucosal surface of the upper airway, the initial step in the disease process. Both host and bacterial factors affecting colonization are under investigation. In general these studies utilize bacterial genetics to examine effects of specific microbial genes together with mouse models of colonization that allow for the use of genetically-modified hosts.

On-going projects examine:

How colonizing microbes stimulate and evade innate and adaptive immune clearance mechanisms.
Mechanisms that facilitate interspecies competition within a host.
Mechanisms of competition between co-colonizing pneumococci.
Effects of influenza co-infection on bacterial colonization.
Pneumococcal interactions with neutrophils/macrophages and mechanisms to evade clearance by professional phagocytes.
The role of phosphorycholine, a surface constituent of many respiratory tract inhabitants, in pathogenesis.
Host and bacterial factors affecting shedding and host to host transmission.
Systemic effects on innate immunity of the colonizing flora (microbiota).

Selected Publications:

Streptococcus pneumoniae Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model.
Zangari T, Wang Y, Weiser JN.
MBio. 2017 Mar 14; 8(2). pii: e00188-17. doi: 10.1128/mBio.00188-17.
PMID: 28292980

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage.
Mitsi E, Roche AM, Reiné J, Zangari T, Owugha JT, Pennington SH, Gritzfeld JF, Wright AD, Collins AM, van Selm S, de Jonge MI, Gordon SB, Weiser JN, Ferreira DM.
Mucosal Immunol. 2017 Mar; 10(2):385-394. doi: 10.1038/mi.2016.71. Epub 2016 Aug 31.
PMID: 27579859

Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.
Zafar MA, Wang Y, Hamaguchi S, Weiser JN.
Cell Host Microbe. 2017 Jan 11; 21(1):73-83. doi: 10.1016/j.chom.2016.12.005.
PMID: 28081446

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.
Hergott CB, Roche AM, Tamashiro E, Clarke TB, Bailey AG, Laughlin A, Bushman FD, Weiser JN.
Blood. 2016 May 19; 127(20):2460-71. doi: 10.1182/blood-2015-10-675173. Epub 2016 Mar 17.
PMID: 26989200

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
Hergott CB, Roche AM, Naidu NA, Mesaros C, Blair IA, Weiser JN.
J Clin Invest. 2015 Oct 1; 125(10):3878-90. doi: 10.1172/JCI81888. Epub 2015 Aug 31.
PMID: 26426079

Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance.
Lemon JK, Miller MR, Weiser JN.
Infect Immun. 2015 Aug; 83(8):3204-12. doi: 10.1128/IAI.00224-15. Epub 2015 Jun 1.
PMID: 26034210

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.
Siegel SJ, Tamashiro E, Weiser JN.
PLoS Pathog. 2015 Jun 24;11(6):e1005004. doi: 10.1371/journal.ppat.1005004. eCollection 2015 Jun.
PMID: 26107875

Mechanisms of Bacterial Colonization of the Respiratory Tract.
Siegel SJ, Weiser JN.
Annu Rev Microbiol. 2015; 69:425-44. doi: 10.1146/annurev-micro-091014-104209. Review.
PMID: 26488280

Lab personnel:

Shigeto Hamaguchi, MD – Visiting Scholar
Alex Hammond – Graduate Student
Kirsten Kuipers, PhD – Postdoctoral Fellow
Kristen Lokken, PhD – Postdoctoral Fellow
Mila Ortigoza, MD, PhD – Infectious Disease Fellow
Jennifer Pagano – Executive Assistant
Pam Shen, PhD – Postdoctoral Fellow
Ammar Zafar, PhD – Research Scientist
Tonia Zangari, PhD – Postdoctoral Fellow

Weiser Lab 2017:

2016

2015: