Genetic Test for Progression of Adolescent Idiopathic Scoliosis

Full Title of Study

Genetic Research to Develop a Diagnostic Tool for the Progression of Adolescent Idiopathic Scoliosis (AIS)

Purpose of Study

There is currently a genetic test that may help determine whether the spinal curve in patients with adolescent idiopathic scoliosis (AIS) is more or less likely to progress to a stage that requires surgical intervention. The test is currently is available only to a small group of patients—specifically, Caucasian females between the ages of 9 and 13 years with minor curves between 10 and 25 degrees. The purpose of this study is to collect many samples from diverse groups of patients in order to make this test applicable to all ethnicities and both genders.

Basic Inclusion Criteria (requirements for being included in study)

  • Diagnosis of adolescent idiopathic scoliosis
  • Documentation of three visits with the study’s principal investigator (Dr. Lonner) or another physician
  • Has either reached skeletal maturity or has completed surgical treatment

Basic Exclusion Criteria (reasons for being excluded from study)

  • Patients with adult-onset, congenital, infantile, degenerative, neuromuscular, trauma-related, or syndromic scoliosis
  • Skeletally immature nonsurgical patients
  • No initial or final cobb angle
  • Incomplete or unavailable clinical notes

Study Visit Requirements


Principal Investigator

Baron Lonner, MD

Answers to frequently asked questions (FAQs) about clinical trials

For more information about enrolling in this study, please contact Alexandra Lee, or 212-598-6114