Jack Rosenbluth

Jack RosenbluthProfessor, Department of Neuroscience & Physiology

 

PHB 833, 455 First Avenue
Room 833 Public Health Building
New York, NY 10016
Tel: 212-263-6326
Email: rosenj03@med.nyu.edu
Curriculum Vitae

Research Summary:

Structure and physiology of normal and pathological myelinated nerve fibers.

 We work on mutant mice that have myelin disorders in order to determine the physiological consequences of loss or damage to specific myelin components.  The myelin defects seen in some of these mutants mimic those in human demyelinating diseases, such as multiple sclerosis, and have been implicated as well in other neurological diseases including schizophrenia.

Our focus has been on ‘subtle’ defects of myelin that could not be detected by MRI or histological stains, but that can nevertheless have devastating functional consequences.  Most recently we have concentrated on the paranodal region where the myelin sheath forms an extraordinarily large and structurally unique junction with the axon.  This junction (PNJ) is exquisitely designed to balance the insulating function of myelin against the metabolic needs of the axon.  Defects in the ‘transverse bands’, a component of the PNJ, result not only in significant impairment in signal propagation but also in shortened lifespan.  These consequences can be accounted for by changes in the permeability of the PNJ, probably resulting in abnormal activation of juxtaparanodal potassium channels located under the myelin sheath, and by progressive disorganization of axonal ion channel domains.  

Further details of the structure and properties of the PNJ, how it changes with activity and what the consequences are of defects in other specific myelin components may clarify the causes of functional impairment in human diseases involving myelin.

Selected Publications:

  • Mierzwa A, Shroff S, and Rosenbluth J (2010) Permeability of the Paranodal Junction  of Myelinated Nerve Fibers. J. Neurosci. 30: 15962-15968

  • Rosenbluth J (2009) Multiple Functions of the Paranodal Junction of Myelinated Nerve Fibers. J. Neurosci. 87: 3250-3258

  • Mierzwa A, Arevalo JC, Schiff R, Chao MV, and Rosenbluth J (2010) Role of Transverse Bands in Maintaining Paranodal Structure and Axolemmal Domain Organization in Myelinated Nerve Fibers: Effect of Longevity in Dysmelinated Mutant Mice. J. Comparative Neurology.518: 2841-2853

  • Shroff S, Mierzwa A, Scherer SS, Peles E, Arevalo JC, Chao MV, and Rosenbluth J (2011) Paranodal Permeability in “Myelin Mutants.” GLIA. 00: 1-11

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