Key Research Articles:


Kuchay S., Giorgi C., Simoneschi D., Pagan J., Missiroli S., Saraf A., Florens L., Washburn M., Collazo A., Castillo M., Cordon-Cardo C., Sebti S., Pinton P., and Pagano M. 

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumor growth

Nature 546:554-558, 2017. (see also related News & Views and News & Thoughts)


Donato V., Bonora, M. Simoneschi D., Sartini D., Kudo Y., Saraf A., Florens L., Washburn M., Stadtfeld M., Pinton, P., and Pagano M.

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. 

Nature Cell Biol 19:341-351, 2017.  (see also related News & Commentary)


Dankert J., Pagan J., Starostina N., Kipreos E., and Pagano M.

FEM1 proteins are ancient regulators of SLBP degradation.

Cell Cycle 16:556-564, 2017.


Dankert J., Rona G., Clijsters L., Geter P., Skaar J., Bermudez K., Sassani E., Fenyo D., Ueberheide B., Schneider R., and Pagano M. 

Cyclin F-mediated degradation of SLBP limits H2A.X accumulation and apoptosis upon genotoxic stress in G2. 

Mol Cell 64:507-519, 2016.  (see also related News & Views 1 and News & Views 2)


Pagan J., Marzio A., Jones M., Saraf A., Jallepalli P., Florens L., Washburn M., and Pagano M.

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement

and licensing.

Nature Cell Biol 17:31-43, 2015.  (see also related News & Views)


Young L.M., Marzio A., Perez-Duran P., Reid D., Meredith D., Roberti, D. Star A., Rothenberg E., Ueberheide B., and Pagano M. TIMELESS forms a complex with PARP1 distinct from its complex with TIPIN and plays a role in the DNA Damage Response

Cell Reports 13:451-459, 2015.


Skaar J., Ferris A., Wu X., Saraf A., Khanna K., Florens L., Washburn M., Hughes S. and Pagano M.

The Integrator complexes regulates processing-coupled termination of transcription at diverse classes of gene targets

Cell Res 25:288-305, 2015. (see also related Mini-Review)


Kuchay S., Duan S., Schenkein E., Peschiaroli A., Saraf A., Florens L., Washburn M., and Pagano M. 

FBXL2- and PTPL1-mediated degradation of p85β controls PI3K activity. 

Nature Cell Biol 15:472-480, 2013.


Rossi M., Duan S., Jeong Y., Horn M., Saraf A., Florens L., Washburn M., Antebi A., and Pagano M. 

Regulation of the CRL4Cdt2 ubiquitin ligase and cell cycle exit by the SCFFbxo11 ubiquitin ligase. 

Mol Cell 49:1159-1166, 2013.


Jeong Y., Rossi M., Cermak L., Saraf A., Florens L., Washburn M., Sung. P, Schildkraut C., and Pagano M. 

FBH1 promotes DNA double strand breakage and apopotosis in response to DNA replication stress. 

J of Cell Biol 200:141-149, 2013.


Jeong Y., Cermak L., GuiJarro M., Hernando E., and Pagano M. 

FBH1 is deregulated in melanomas and protects melanocytes from transformation. 

Cell Cycle 12:1128-1132, 2013.


D'Angiolella V., Donato V., Jeong Y., Forrester F., Kudo, Y., Pellacani C., Saraf A., Florens L., Washburn M., and Pagano M.
Cyclin F-dependent degradation of Ribonucleotide Reductase M2 controls genome stability and DNA repair.
Cell 149:1023-1034, 2012.


Busino L., Millman S., L. Scotto, Kyratsous C., Basrur V., Hoffmann A., O'Connor O., Elenitoba-Johnson K. S., and Pagano M.
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.
Nature Cell Biol, 14:375-385, 2012.


Duan S., L. Cermak, J. Pagan, M. Rossi, C. Martinengo , P. DiCelle, B. Chapyuy, M. Shipp, R. Chiarle, and Pagano M.
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.
Nature 481:90-93, 2012.


Duan S., Skaar J.R., Tosci A., Kanarek N., Ben-Neriah Y., and Pagano M.
mTOR generates an auto-amplification loop by triggering the βTrCP- and Ck1α-dependent degradation of DEPTOR.
Mol Cell 44;317-324, 2011.


D’Angiolella, V. Donato, S. Vijayakumar, A. Saraf, L. Florens, M. Washburn, B. Dynlacht, and Pagano M.
SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation.
Nature 466:138-142, 2010.


Skaar J., D. Richard, A. Tosci, A. Saraf, E. Bolderson, L. Florens, M. Washburn, K. Khanna, and Pagano M.
INTS3 controls the hSSB1-mediated DNA damage response.
J of Cell Biol 187:25-32, 2009.


Dehan E., F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K. Lowes, M. Dustin, D. Huang, J. Taunton, and Pagano M.
βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Mol Cell 33:109-111, 2009.


Bassermann F., D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and Pagano M.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint.
Cell 134:256-267, 2008.


Guardavaccaro D., D. Frescas, N. Dorrello, A. Peschiaroli, A. Multani, T. Cardozo, A. Lasorela, A. Iavarone, S. Chang, E. Hernando, and Pagano M.
Control of chromosome stability by the βTRCP-REST-MAD2 axis.
Nature 452:365-369, 2008.


Frescas D., D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and M. Pagano.
The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Nature 450:309-313, 2007.


Busino L., F. Bassermann, A. Maiolica, C Lee, S. Godinho, P. Nolan, G. Draetta and Pagano M.
SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins.
Science 316:900-904, 2007.


Amador V., S. Ge, P.G. Santamaria, D. Guardavaccaro and Pagano M.
APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase.
Mol Cell 27:462-473, 2007.


Dorrello N. V., A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman and Pagano M.
S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Science 314:467-471, 2006.


Peschiaroli A., N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N. Sherman and Pagano M..
SCFβTRCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Mol Cell 23:319-329, 2006.


Kudo Y., D. Guardavaccaro, P. Santamaria, R. Nasu, E. Latres, R. Bronson, L. Yamasaki and Pagano M.
Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis.
Mol Cell Biol 24:8184-8194, 2004.

Bashir T., V. Dorrello, V. Amador, D. Guardavaccaro and Pagano M.
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase.
Nature 248:190-193, 2004.

Bloom J., V. Amador, F. Bartolini, G. DeMartino and Pagano M.
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.
Cell 115:71-82, 2003.

Guardavaccaro D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin, P. Jackson, Yamasaki L. and Pagano M.
Control of meiotic and mitotic progression by the F-box protein βTrcp1 in vivo.
Dev. Cell 4: 799-812, 2003.

Signoretti S., L. Dimarcotullio, A. Richardson, S. Ramaswamy, B. Isaac, M. Rue, F. Monti, M. Loda and Pagano M.
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.
J of Clinical Investigation 110:633-641, 2002.

Carrano A. C. and Pagano M..
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.
J of Cell Biology 153: 1381-1389, 2001.

Latres E., R. Chiarle, B. Schulman, N. Pavletich, A. Pellicer, G. Inghirani and Pagano M.
Role of the F-box protein Skp2 in lymphomagenesis.
Proc Natl Acad Sci USA 98: 2515-2520, 2001.

Cenciarelli C., D. S. Chiaur, D. Guardavaccaro, W. Parks, M. Vidal, and Pagano M.
Identification of a family of human F-box proteins.
Current Biology 9: 1177-1179, 1999.

Carrano A. C., E. Eytan, A. Hershko, and Pagano M.
Skp2 is required for the ubiquitin-mediated degradation of the Cdk-inhibitor p27.
Nature Cell Biol 1: 193-199, 1999.

Montagnoli A., F. Fiore, E. Eytan, A. C. Carrano, G. Draetta, A. Hershko, and Pagano M.
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Genes & Development 13: 1181-1189, 1999.

Latres E., D. S. Chiaur, and Pagano M.
The human F-box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of b-catenin.
Oncogene 18: 849-854, 1999.

Loda M., B. Cukon, S. Tam, P. Lavin, M. Fiorentino, G. Draetta, J. Jessup, and Pagano M.
Increased proteasome-dependent degradation of the CDK inhibitor p27 in aggressive colorectal carcinomas.
Nature Med 3: 231-234, 1997.

Pagano M., S. Tam, A. Theodoras, P. Beer, S. Delsal, V. Chu, R. Yew, G. Draetta, and M. Rolfe.
Role of the Ubiquitin-Proteasome pathway in regulating abundance of the CDK inhibitor p27.
Science 269: 682-685, 1995.

Pagano M., A. M. Theodoras, S. W. Tam, and G. Draetta.
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.
Genes & Development 8: 1627-1639, 1994.

Pagano M., R. Pepperkok, J. Lukas, V. Baldin, W. Ansorge, J. Bartek, and G. Draetta.
Regulation of the cell cycle by the Cdk2 protein kinase in cultured human fibroblasts.
J of Cell Biology 121: 101- 111, 1993.

Pagano M., M. Dürst, S. Joswig, G. Draetta, and P. Jansen-Dürr.
Binding of the human E2F transcription factor to the retinoblastoma protein but not Cyclin A is abolished in HPV 16-immortalized cells.
Oncogene 7: 1681-1686, 1992.

Pagano M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta.
Cyclin A is required at two points in the human cell cycle.
EMBO J 11: 961-972, 1992.

Pagano M., Draetta G., and Jansen-Dürr P.
Association of Cdk2 kinase with the transcription factor E2F during S phase.
Science 255: 1144-1147, 1992.

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