Isabelle J. Marié, Ph.D.

Isabelle J. Marié, Ph.D.
Assistant Professor of Pathology

Immunology / Interferon, Innate Immune Response, Jak-Stat signaling pathway

isabelle.marie@med.nyu.edu, (212) 263 0914 , (212) 263 8705
Fax: (212) 263 8211
550 First Avenue, MSB 556, New York, NY 10016

 

Research and Clinical Interests

The innate immune response provides the first line of defense against infection. We study the type I interferon (IFN) system, an essential component of innate immunity to viral infection, focusing on how cells recognize infectious organisms and induce IFN production, how they respond to secreted IFN to establish an antiviral state, and how these events are orchestrated at the molecular level using paramyxoviruses, herpesviruses, and poxviruses as model systems in gene-targeted mice.

Selected Publications

Levy DE, Marie IJ. RIGging an antiviral defense--it's in the CARDs. Nat Immunol. 2004 Jul;5(7):699-701. Cited in Pubmed; PMID 15224097.

Chang HM, Paulson M, Holko M, Rice CM, Williams BR, Marie I, Levy DE. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9578-83. Epub 2004 Jun 21. Cited in Pubmed; PMID 15210966.

Levy DE, Marie I, Prakash A. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr Opin Immunol. 2003 Feb;15(1):52-8. Cited in Pubmed; PMID 12495733.

Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marie I. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002 Dec 20;277(51):49417-21. Cited in Pubmed; PMID 12374802.

Smith EJ, Marie I, Prakash A, Garcia-Sastre A, Levy DE. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem. 2001 Mar 23;276(12):8951-7. Epub 2000 Dec 21. Cited in Pubmed; PMID 11124948.

Marie I, Smith E, Prakash A, Levy DE. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol. 2000 Dec;23:8803-14. Cited in Pubmed; PMID 11073981.

Marie I, Rebouillat D, Hovanessian AG. The expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response. Eur J Biochem. 1999 May;262(1):155-65. Cited in Pubmed; PMID 10231377.

Rebouillat D, Hovnanian A, Marie I, Hovanessian AG. The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. J Biol Chem. 1999 Jan 15;274(3):1557-65. Cited in Pubmed; PMID 9880533.

Marie I, Durbin JE, Levy DE. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 1998 Nov 16;17(22):6660-9. Cited in Pubmed; PMID 9822609.

Rebouillat D, Marie I, Hovanessian AG. Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Eur J Biochem. 1998 Oct 15;257(2):319-30. Cited in Pubmed; PMID 9826176.

Selected Books

Levy DE, Marie IJ. How viruses elicit interferon production: triggering the innate immune response to viral infection. Chapter 2. In: Chaugeux JP, Palese P, editors. Modulation of Host Gene Expression and of Innate Immunity by Viruses. Dordrecht: Kluwer Academic Publishers; 2005.

Organizational Associations

International Society for Interferon and Cytokine Research

Selected Awards

Christina Fleishmann Award from the International Society for Interferon and Cytokine Research