the philips lab
departments of medicine, cell biology and pharmacology, NYU cancer institute, Division of Rheumatology, NYU School of Medicine

The complexity and regulation of the subcellular localization of signaling molecules allows for a broader repertoire of functional output.

Our focus: how the trafficking of small GTPases relates to their function.
Read more about the lab and our research

research update

The K-Ras farnesyl-electrostatic switch…
The localization of K-Ras is regulated by a farnesyl-electrostatic that is activated by phosphorylation by PKC of serine 181 of K-Ras.  Moreover, phosphorylated, internalized K-Ras engages a pro-apoptotic pathway.

Compartmentalized Ras signaling in fission yeast…
In Schizosaccharomyces pombe, whereas Ras1 at the plasma membrane regulates mating through a MAPK pathway, the same GTPase regulates elongated morphology through Cdc42 when positioned on endomembrane.