the philips lab
departments of medicine, cell biology and pharmacology, NYU cancer institute, Division of Rheumatology, NYU School of Medicine

Peer Reviewed

Dai Q, Choy E, Chiu V, Slivka SR, Steitz S, Michaelis S, and Philips MR. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J. Biol. Chem. 273:15,030-15,034, 1998.

Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, and MR Philips. Endomembrane Trafficking of Ras: the CAAX Motif Targets Proteins to the ER and Golgi. Cell 98:69-80, 1999.

Michaelson D,Silletti J, Murphy G, D’Eustachio P, Rush M, and Philips MR. Differential Localization of Rho GTPases in Live Cells: Regulation by hypervariable domains and RhoGDI binding. J. Cell Biol., 152:111-126, 2001.

Chiu VK*, Bivona T*, Hach A, Sajous JB, Silletti J, Wiener H, Johnson II RL, Cox AD and Philips MR. Ras signalling on endoplasmic recticulum and Golgi. Nature Cell Biol. 4:343-350, 2002.

Michaelson D, Ahearn I, Bergo M, Young S, and Philips MR. Membrane trafficking of heterotrimeric G Proteins via the endoplasmic reticulum. Mol Biol. Cell. 13:3294-3302, 2002.

Bivona TG, Pérez de Castro, Ahearn I, Grana TM, Chiu VK, Lockyer P, Cullen P, Pellicer A, Cox AD and Philips MR. Golgi-specific Activation of Ras by PLCÁ and RasGRP1. Nature. 424:694-698, 2003.

Chiu VK, Silletti J, Dinsell V, Wiener H, Loukeris K, Ou G, Philips MR, and Pillinger M. Carboxyl Methylation of Ras Regulates Membrane Targeting and Effector Engagement. J. Biol. Chem. 279:7346-52, 2004.

Bivona T, Wiener HH, Silletti, J. Chiu VK and Philips MR. Upregulation and activation of Rap1a on the plasma membrane regulates T cell adhesion. J. Cell Biol. 164:461-470, 2004.

Pérez de Castro I, Bivona TG, Philips MR, and Pellicer A. T cell receptors activate N-ras exclusively on Golgi. Mol. Cell. Biol. 24:3485-96, 2004.

Michaelson D, Ali W, Chiu V., Bergo M, Silletti J, Wright L, Young S, and Philips MR. Postprenylation CAAX Processing Is Required for Proper Localization of Ras but not Rho GTPases. Mol. Biol. Cell 16:1606-16, 2005.

Bivona TG*, Quatela S*, Bodemann BO, Ahearn I, Soskis MJ, Mor A, Miura J, Wiener H, Wright L, Saba SG, Yim D, Fein A., Pérez de Castro I, Thompson, CB, Cox AD and Philips MR. Phosphorylation of K-Ras by PKC regulates a farnesyl-electrostatic switch that promotes association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell. 21:481-93, 2006.

Onken, B, Philips MR and Chang EC. Compartmentalized signaling of ras in fission yeast. Proc. Nat. Acad. Sci. In Press.

Yeung T, Terebiznik M, Yu L, Silvius J, Philips MR, Levine T, Kapus A and Grinstein S.  Localized changes of surface potential during phagocytosis: critical role in signal transduction.  Science, in press.

Recent Reviews

Mor A and Philips MR. Compartmentalized Ras/MAPK Signaling. Annu Rev Immunol. 24:771-800, 2006.

Onken, B, Weiner H, Chang EC* and Philips MR*.  Compartmentalized signaling of ras in fission yeast.  Proc. Nat. Acad. Sci.  103:9045-50, 2006. *Dual corresponding authors.