Post-translational modification of small GTPases.
Isoprenylcysteine carboxyl methyltransferase (Icmt), the third of the three CAAX processing enzymes.
Focus on the pathways that deliver GTPases to target membranes, how these pathways are regulated and how they relate to signaling.
Focus on the differential localization of Ras and Rho family GTPases and how subcellular location relates to function.
Focus on the biological significance of compartmentalized signaling.
Ras Activation in T Cells
Focus on the biological advantages of endomembrane Ras signaling in immune cells and the role that Ras signaling plays in autoimmunity.
K-Ras Phosphorylation and the Farnesyl-electrostatic Switch
A novel way of treating human tumors with PKC.